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N-(3-Methylphenyl)-N-propylamine: A Comprehensive Overview

The compound with CAS No. 142031-46-7, commonly referred to as N-(3-Methylphenyl)-N-propylamine, is a versatile organic compound that has garnered significant attention in various scientific and industrial applications. This compound, also known as N-propyl-N-(3-methylphenyl)amine, belongs to the class of secondary amines and is characterized by its unique structure and properties. In this article, we delve into the chemical structure, physical and chemical properties, synthesis methods, applications, and recent research findings related to this compound.

Chemical Structure and Properties

N-(3-Methylphenyl)-N-propylamine features a benzene ring substituted with a methyl group at the para position, connected to an amine group via a propyl chain. The molecular formula of this compound is C11H17N, with a molecular weight of approximately 165.25 g/mol. The compound exhibits a melting point of around -5°C and a boiling point of about 185°C under standard conditions. Its density is approximately 0.89 g/cm3, making it less dense than water.

Synthesis Methods

The synthesis of N-(3-Methylphenyl)-N-propylamine can be achieved through various methods, including nucleophilic substitution reactions and reductive amination. One common approach involves the reaction of 3-methylbenzaldehyde with propylamine in the presence of a reducing agent such as sodium cyanoborohydride or hydrogen gas. This method ensures high yield and purity, making it suitable for large-scale production.

Applications in Industry and Research

N-(3-Methylphenyl)-N-propylamine finds extensive use in the pharmaceutical industry as an intermediate in the synthesis of various bioactive compounds. Its ability to form stable complexes with metal ions makes it valuable in catalytic processes and chelation therapy. Additionally, this compound is employed in the production of agrochemicals, where it serves as a precursor for herbicides and insecticides.

Recent studies have highlighted its potential in the field of materials science, particularly in the development of novel polymers and coatings. Researchers have explored its role as a building block for creating self-healing materials due to its ability to undergo reversible chemical transformations under specific conditions.

Safety and Handling

While handling N-(3-Methylphenyl)-N-propylamine, it is essential to adhere to standard safety protocols. The compound is generally considered non-toxic but may cause skin irritation upon prolonged exposure. Proper ventilation should be ensured during its synthesis and use to avoid inhalation hazards.

Conclusion

N-(3-Methylphenyl)-N-propylamine stands out as a significant compound with diverse applications across multiple disciplines. Its unique chemical properties, coupled with recent advancements in synthesis techniques and application areas, underscore its importance in modern chemistry. As research continues to uncover new potentials for this compound, it is poised to play an even more prominent role in both academic and industrial settings.

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