• 1. Dissociative electron attachment to HGaF4 Lewis–Br?nsted superacid
  Marcin Czapla,Jack Simons Phys. Chem. Chem. Phys., 2018,20, 21739-21745
• 2. Evolution of dealloying induced strain in nanoporous gold crystals?
  Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693
• 3. Fe(iii)-mediated isomerization of α,α-diarylallylic alcohols to ketones via radical 1,2-aryl migration?
  Ziyang Deng,Changwei Chen,Sunliang Cui RSC Adv., 2016,6, 93753-93755
• 4. Evolutionary de novo design of phenothiazine derivatives for dye-sensitized solar cells?
  Vishwesh Venkatraman,Marco Foscato,Vidar R. Jensen,Bj?rn K?re Alsberg J. Mater. Chem. A, 2015,3, 9851-9860
• 5. Establishing plasmon contribution to chemical reactions: alkoxyamines as a thermal probe?
  Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161

• Solvents and Organic Chemicals Organic Compounds Alkaloids and derivatives Emetine alkaloids Emetine alkaloids
• Solvents and Organic Chemicals Organic Compounds Alkaloids and derivatives Emetine alkaloids

EMetine Hydrochloride (CAS No. 14198-59-5): A Comprehensive Overview

EMetine Hydrochloride, a derivative of the naturally occurring compound emetine, is widely recognized for its significant pharmacological properties. With the chemical formula C₂₀H₂₄N₂O₄·HCl, this compound is primarily utilized in pharmaceutical research and development due to its unique biological activities. The CAS No. 14198-59-5 uniquely identifies this substance, ensuring precise classification and regulatory compliance in various scientific and industrial applications.

The compound's structural framework and chemical properties make it a subject of intense interest in the field of medicinal chemistry. Specifically, the hydrochloride salt form enhances its solubility and bioavailability, making it more effective in therapeutic contexts. Research has demonstrated that EMetine Hydrochloride exhibits potent effects on multiple biological targets, including microtubule inhibition, which has implications for its potential use in cancer treatment.

In recent years, studies have highlighted the compound's role in combating drug-resistant pathogens. The EMetine Hydrochloride molecule has shown promise in disrupting bacterial biofilms and inhibiting the growth of certain resistant strains. This discovery has sparked further investigation into its mechanisms of action and potential applications in antibiotic-resistant infections.

The pharmacokinetic profile of EMetine Hydrochloride is another area of active research. Investigations have revealed that the compound undergoes rapid absorption and distribution within the body, followed by gradual metabolism. This profile suggests that EMetine Hydrochloride could be a valuable candidate for oral administration in therapeutic formulations. Additionally, studies have explored its interactions with various enzymes and transporters, providing insights into how it can be optimized for maximum efficacy.

Beyond its antimicrobial properties, EMetine Hydrochloride has been investigated for its potential neuroprotective effects. Preclinical studies have indicated that it may help mitigate neurodegenerative damage by modulating inflammatory pathways and protecting against oxidative stress. These findings have opened new avenues for research into treating conditions such as Alzheimer's disease and Parkinson's disease.

The synthesis of EMetine Hydrochloride is another critical aspect of its study. Researchers have developed several synthetic routes to produce this compound with high purity and yield. Advanced techniques such as catalytic hydrogenation and enzymatic modification have been employed to optimize the synthesis process. These advancements not only improve the accessibility of EMetine Hydrochloride but also contribute to cost-effective production for clinical trials and commercial applications.

The safety profile of EMetine Hydrochloride is a paramount consideration in its development. While it exhibits potent biological activity, it also demonstrates certain toxicities at high doses. Therefore, researchers are focusing on identifying safe dosage regimens and delivery systems to minimize adverse effects. Pharmacogenomic studies are being conducted to understand how genetic variations among individuals influence their response to EMetine Hydrochloride, thereby paving the way for personalized medicine approaches.

The regulatory landscape surrounding EMetine Hydrochloride is evolving in response to new scientific findings. Regulatory agencies are increasingly recognizing the potential of this compound and are streamlining pathways for its approval in various therapeutic areas. Collaborative efforts between academia, industry, and regulatory bodies are essential to ensure that EMetine Hydrochloride reaches patients who could benefit from its therapeutic properties.

In conclusion, EMetine Hydrochloride (CAS No. 14198-59-5) is a multifaceted compound with significant potential in pharmaceutical applications. Its unique chemical properties, combined with ongoing research into its mechanisms of action and safety profiles, position it as a promising candidate for treating a range of diseases. As scientific understanding continues to advance, the applications of EMetine Hydrochloride are expected to expand, offering new hope for patients worldwide.

• 436-77-1(Fangchinoline)
• 52-53-9(verapamil)
• 475-83-2(Nuciferine)
• 131-10-2((-)-Berbine)
• 404-86-4(Capsaicin)
• 3466-75-9(Hydroxy Tetrabenazine - Mixture of cis and trans Isomers)
• 483-17-0(Cephaeline)
• 475-67-2(Isocorydine)
• 476-70-0(Boldine)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)