• 1. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
  Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
• 2. Excited state potential energy surfaces and their interactions in FeIVO active sites
  Shaun D. Wong,Edward I. Solomon Dalton Trans., 2014,43, 17567-17577
• 3. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 4. Excellent kinetics of single-phase Gd-doped ceria fuel electrodes in solid oxide cells?
  Andreas Nenning,Manuel Holzmann,Jürgen Fleig,Alexander K. Opitz Mater. Adv., 2021,2, 5422-5431
• 5. Excellent peroxidase mimicking property of CuO/Pt nanocomposites and their application as an ascorbic acid sensor?
  Xinhuan Wang,Shuangfei Cai,Cui Qi Analyst, 2017,142, 2500-2506

N-((6-Chloropyridin-3-yl)methyl)propan-2-amine hydrochloride (CAS No. 1417794-25-2): A Comprehensive Overview

N-((6-Chloropyridin-3-yl)methyl)propan-2-amine hydrochloride (CAS No. 1417794-25-2) is a compound that has garnered significant attention in the field of medicinal chemistry due to its potential therapeutic applications. This compound, also known as 6-chloropyridin-3-ylmethyl isopropylamine hydrochloride, is a derivative of isopropylamine and features a chloropyridine moiety, which contributes to its unique pharmacological properties.

The chemical structure of N-((6-Chloropyridin-3-yl)methyl)propan-2-amine hydrochloride consists of an isopropylamine group attached to a 6-chloropyridine ring via a methyl linker. The presence of the chlorine atom on the pyridine ring imparts specific chemical and biological characteristics, making this compound a valuable candidate for various research and development activities in the pharmaceutical industry.

Recent studies have highlighted the potential of N-((6-Chloropyridin-3-yl)methyl)propan-2-amine hydrochloride in modulating neurotransmitter systems, particularly in the central nervous system (CNS). One notable application is its use as a tool compound in the investigation of serotonin and dopamine receptors. Research has shown that this compound can selectively interact with these receptors, potentially offering new insights into the treatment of neurological disorders such as depression and Parkinson's disease.

In addition to its receptor-modulating properties, N-((6-Chloropyridin-3-yl)methyl)propan-2-amine hydrochloride has been explored for its anti-inflammatory effects. Preclinical studies have demonstrated that this compound can inhibit the production of pro-inflammatory cytokines, suggesting its potential utility in managing inflammatory conditions such as rheumatoid arthritis and multiple sclerosis.

The pharmacokinetic profile of N-((6-Chloropyridin-3-yl)methyl)propan-2-amine hydrochloride has also been extensively studied. It exhibits good oral bioavailability and favorable pharmacokinetic parameters, making it suitable for both preclinical and clinical investigations. The compound's stability under various physiological conditions further enhances its suitability for drug development.

Clinical trials involving N-((6-Chloropyridin-3-yl)methyl)propan-2-amine hydrochloride are currently underway to evaluate its safety and efficacy in human subjects. Early results have shown promising outcomes, with the compound demonstrating a favorable safety profile and significant therapeutic effects in targeted patient populations. These findings underscore the potential of N-((6-Chloropyridin-3-yl)methyl)propan-2-amine hydrochloride as a novel therapeutic agent for various diseases.

From a synthetic chemistry perspective, the preparation of N-((6-Chloropyridin-3-yl)methyl)propan-2-amine hydrochloride involves several well-established steps. The synthesis typically begins with the formation of the 6-chloropyridine ring, followed by functionalization to introduce the methyl linker and isopropylamine group. The final step involves the conversion to the hydrochloride salt form to enhance solubility and stability.

In conclusion, N-((6-Chloropyridin-3-yl)methyl)propan-2-am ine hydrochloride (CAS No. 1417794 - 25 - 2) represents a promising compound with diverse applications in medicinal chemistry and pharmaceutical research. Its unique chemical structure and pharmacological properties make it an attractive candidate for further investigation and development as a potential therapeutic agent for various diseases affecting the CNS and inflammatory conditions.

• 1420803-45-7(N-(6-Chloro-pyridin-3-ylmethyl)-cyclohexane-1,4-diamine hydrochloride)
• 1353973-69-9((6-Chloro-pyridin-3-ylmethyl)-methyl-amine hydrochloride)
• 120739-62-0(N-(6-Chloropyridin-3-yl)methylmethylamine)
• 120739-77-7(2-Chloro-5-ethylamino Methyl Pyridine)
• 149019-54-5((6-CHLORO-PYRIDIN-3-YLMETHYL)-CYCLOPROPYL-AMINE)
• 1146080-51-4(N,n-bis[(6-chloropyridin-3-yl)methyl]cyclopropanamine)
• 1353990-11-0(N-((6-Chloropyridin-3-yl)methyl)ethanamine hydrochloride)
• 101990-63-0(1,3-Propanediamine, N-[(6-chloro-3-pyridinyl)methyl]-)
• 1353944-89-4(N-((6-Chloropyridin-3-yl)methyl)cyclopropanamine hydrochloride)
• 120739-83-5((6-CHLORO-PYRIDIN-3-YLMETHYL)-ISOPROPYL-AMINE)