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Comprehensive Overview of 5-Bromo-3-fluoro-quinoline (CAS No. 1416440-63-5): Properties, Applications, and Market Trends

5-Bromo-3-fluoro-quinoline (CAS No. 1416440-63-5) is a halogenated quinoline derivative that has garnered significant attention in pharmaceutical and agrochemical research due to its unique structural features. The compound's molecular formula, C₉H₅BrFN, combines a bromine atom at the 5-position and a fluorine atom at the 3-position, enhancing its reactivity and bioactivity. This article explores its synthesis, applications, and relevance in modern scientific advancements, addressing frequently searched queries like "5-bromo-3-fluoro-quinoline uses" and "CAS 1416440-63-5 suppliers."

The synthesis of 5-Bromo-3-fluoro-quinoline typically involves palladium-catalyzed cross-coupling reactions or direct halogenation of quinoline precursors. Researchers emphasize its role as a building block in drug discovery, particularly for kinase inhibitors and antimicrobial agents. A 2023 study highlighted its potential in targeting drug-resistant pathogens, aligning with the global focus on antibiotic alternatives. Its lipophilicity and electron-withdrawing properties make it valuable for optimizing pharmacokinetic profiles in lead compounds.

In agrochemicals, 5-Bromo-3-fluoro-quinoline derivatives are explored for their herbicidal and fungicidal activities. With the rising demand for sustainable crop protection, this compound's mode of action—disrupting fungal cell membranes—resonates with trends in green chemistry. Industry reports link its derivatives to low-toxicity formulations, addressing searches like "eco-friendly quinoline-based pesticides."

The compound's spectroscopic data (e.g., ¹H NMR: δ 8.9 ppm for quinoline-H) and crystallographic studies are well-documented, aiding in quality control. Analytical techniques such as HPLC-MS ensure purity for high-value applications. Suppliers often provide custom synthesis services, catering to niche demands like "1416440-63-5 for research."

Emerging trends include its integration into OLED materials, where its fluorescence properties are exploited for energy-efficient displays. Patent analyses reveal growing interest in electronic applications, coinciding with searches for "quinoline derivatives in optoelectronics."

Regulatory compliance for CAS 1416440-63-5 follows standard halogenated compound guidelines, with no restrictive classifications. Safety data sheets recommend handling under ventilated conditions, reflecting lab safety priorities. Storage stability (-20°C, inert atmosphere) is critical for long-term use.

In conclusion, 5-Bromo-3-fluoro-quinoline bridges multiple disciplines—from medicinal chemistry to material science. Its versatility and alignment with industry pain points (e.g., antimicrobial resistance, sustainable agriculture) ensure sustained relevance. Future research may unlock novel applications in catalysis or bioconjugation, further expanding its commercial footprint.

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