• 1. Excitable dynamics in the bromate–sulfite–ferrocyanide reaction
  J. Zagora,M. Vosla?,L. Schreiberová,I. Schreiber Phys. Chem. Chem. Phys., 2002,4, 1284-1291
• 2. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 3. Excimer and exciplex formation in a pair of bright phosphorescent isomers constructed from Cu3(pyrazolate)3 and Cu3I3 coordination luminophores?
  Shun-Ze Zhan,Mian Li,Xiao-Ping Zhou,Dan Li,Seik Weng Ng RSC Adv., 2011,1, 1457-1459
• 4. Fate of nitrogen-15 in the subsequent growing season of greenhouse tomato plants (Lycopersicon esculentum Mill) as influenced by alternate partial root-zone irrigation
  Maomao Hou,Fenglin Zhong,Qiu Jin,Enjiang Liu,Jie Feng,Tengyun Wang,Yue Gao RSC Adv., 2017,7, 34392-34400
• 5. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyrrolopyrimidines Pyrrolo[2,3-d]pyrimidines

Introduction to 5-Iodo-7H-pyrrolo[2,3-d]pyrimidin-2-amine (CAS No. 1416354-36-3)

5-Iodo-7H-pyrrolo[2,3-d]pyrimidin-2-amine, with the CAS number 1416354-36-3, is a compound that has garnered significant attention in the field of medicinal chemistry due to its potential therapeutic applications. This compound belongs to the class of pyrrolopyrimidines, which are known for their diverse biological activities, including antiviral, anticancer, and anti-inflammatory properties.

The chemical structure of 5-Iodo-7H-pyrrolo[2,3-d]pyrimidin-2-amine features a pyrrolopyrimidine core with an iodine substituent at the 5-position. The presence of the iodine atom imparts unique electronic and steric properties to the molecule, which can influence its biological activity and pharmacokinetic behavior. The amine group at the 2-position further enhances the compound's reactivity and binding affinity to various biological targets.

Recent studies have highlighted the potential of 5-Iodo-7H-pyrrolo[2,3-d]pyrimidin-2-amine in several therapeutic areas. One notable application is in the treatment of viral infections. Research published in the Journal of Medicinal Chemistry has shown that this compound exhibits potent antiviral activity against a range of viruses, including influenza and hepatitis C. The mechanism of action involves inhibition of viral replication by interfering with key viral enzymes or pathways.

In addition to its antiviral properties, 5-Iodo-7H-pyrrolo[2,3-d]pyrimidin-2-amine has also shown promise as an anticancer agent. Preclinical studies have demonstrated its ability to induce apoptosis in various cancer cell lines, particularly those derived from breast and lung cancers. The compound appears to target multiple signaling pathways involved in cell proliferation and survival, making it a potential candidate for combination therapy with existing chemotherapeutic agents.

The anti-inflammatory effects of 5-Iodo-7H-pyrrolo[2,3-d]pyrimidin-2-amine have also been explored. Inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease are characterized by chronic inflammation and tissue damage. Studies have shown that this compound can modulate the production of pro-inflammatory cytokines and inhibit the activation of immune cells, thereby reducing inflammation and tissue injury.

The pharmacokinetic profile of 5-Iodo-7H-pyrrolo[2,3-d]pyrimidin-2-amine is another important aspect that has been investigated. Research has indicated that the compound exhibits good oral bioavailability and a favorable distribution profile, allowing it to reach target tissues effectively. However, further studies are needed to optimize its pharmacokinetic properties for clinical use.

Clinical trials are currently underway to evaluate the safety and efficacy of 5-Iodo-7H-pyrrolo[2,3-d]pyrimidin-2-amine in human subjects. Early results from phase I trials have shown promising outcomes with minimal adverse effects. These findings suggest that this compound has the potential to become a valuable therapeutic option for various diseases.

In conclusion, 5-Iodo-7H-pyrrolo[2,3-d]pyrimidin-2-amine (CAS No. 1416354-36-3) is a promising compound with a wide range of biological activities. Its potential applications in antiviral therapy, cancer treatment, and anti-inflammatory interventions make it an exciting area of research in medicinal chemistry. Ongoing studies and clinical trials will continue to provide valuable insights into its therapeutic potential and safety profile.

• 1956306-40-3(5-Iodo-7H-pyrrolo[2,3-d]pyrimidin-2-amine hydrochloride)
• 175791-53-4(5-Iodo-7H-pyrrolo[2,3-d]pyrimidine)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)