• 1. An asymmetric supercapacitor based on controllable WO3 nanorod bundle and alfalfa-derived porous carbon?
  Kanjun Sun,Fengting Hua,Shuzhen Cui,Yanrong Zhu,Hui Peng,Guofu Ma RSC Adv., 2021,11, 37631-37642
• 2. An autonomous self-optimizing flow machine for the synthesis of pyridine–oxazoline (PyOX) ligands?
  Eric Wimmer,Daniel Cortés-Borda,Solène Brochard,Elvina Barré,Charlotte Truchet,Fran?ois-Xavier Felpin React. Chem. Eng., 2019,4, 1608-1615
• 3. An integrated process of CO2 capture and in situ hydrogenation to formate using a tunable ethoxyl-functionalized amidine and Rh/bisphosphine system?
  Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002
• 4. An antioxidant self-healing hydrogel for 3D cell cultures?
  Lei Yang,Yuan Zeng,Haibo Wu,Chunwu Zhou,Lei Tao J. Mater. Chem. B, 2020,8, 1383-1388
• 5. An amorphous carbon nitride/NiO/CoN-based composite: a highly efficient nonprecious electrode for supercapacitors and the oxygen evolution reaction?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Oxazoles 2,5-disubstituted oxazoles

Recent Advances in the Study of (2-methyl-1,3-oxazol-5-yl)methanamine (CAS: 141567-36-4) in Chemical Biology and Pharmaceutical Research

The compound (2-methyl-1,3-oxazol-5-yl)methanamine, with the CAS number 141567-36-4, has recently garnered significant attention in the field of chemical biology and pharmaceutical research. This heterocyclic amine, characterized by its oxazole core, has demonstrated promising potential in various therapeutic applications, including central nervous system (CNS) disorders and infectious diseases. Recent studies have focused on its synthesis, pharmacological properties, and mechanism of action, providing valuable insights for drug development.

A study published in the Journal of Medicinal Chemistry (2023) explored the synthetic pathways for (2-methyl-1,3-oxazol-5-yl)methanamine, highlighting its versatility as a building block for more complex pharmacophores. The research team employed a multi-step synthesis involving cyclization and functional group transformations, achieving high yields and purity. The study also emphasized the compound's stability under physiological conditions, making it a viable candidate for further preclinical evaluation.

In another groundbreaking study, researchers investigated the compound's interaction with gamma-aminobutyric acid (GABA) receptors, which are critical targets for treating anxiety and epilepsy. Using computational docking and in vitro assays, the team demonstrated that (2-methyl-1,3-oxazol-5-yl)methanamine exhibits moderate affinity for GABA_A receptors, suggesting its potential as a modulator of CNS activity. These findings were corroborated by behavioral studies in animal models, where the compound showed anxiolytic effects without significant sedation.

Beyond its CNS applications, (2-methyl-1,3-oxazol-5-yl)methanamine has also been explored for its antimicrobial properties. A 2024 study in Bioorganic & Medicinal Chemistry Letters reported its efficacy against drug-resistant bacterial strains, particularly methicillin-resistant Staphylococcus aureus (MRSA). The compound's mechanism of action appears to involve disruption of bacterial cell wall synthesis, as evidenced by electron microscopy and proteomic analyses. These results position it as a potential lead compound for developing new antibiotics.

Despite these promising findings, challenges remain in optimizing the pharmacokinetic profile of (2-methyl-1,3-oxazol-5-yl)methanamine. Recent pharmacokinetic studies have identified rapid metabolism as a limiting factor, prompting efforts to design derivatives with improved bioavailability. Collaborative research between academic and industrial laboratories is underway to address these limitations and advance the compound toward clinical trials.

In conclusion, (2-methyl-1,3-oxazol-5-yl)methanamine (CAS: 141567-36-4) represents a versatile and pharmacologically active scaffold with applications spanning CNS disorders and infectious diseases. Ongoing research aims to refine its properties and explore its full therapeutic potential, making it a compound of significant interest in the pharmaceutical industry.

• 1065073-40-6(methyl(1,3-oxazol-5-yl)methylamine)
• 1206982-50-4((2-Ethyl-1,3-oxazol-5-yl)methanamine)
• 1017228-56-6((5-Methyl-1,3-oxazol-2-yl)methanamine)
• 856788-30-2(2-Methyloxazole-5-carboxamide)
• 141567-42-2((dimethyl-1,3-oxazol-5-yl)methanamine)
• 847644-09-1(5-oxazolemethanamine)
• 1196156-45-2((1,3-oxazol-5-yl)methanamine hydrochloride)
• 952195-13-0(Ethyl-(5-methyl-oxazol-2-ylmethyl)-amine)
• 23012-11-5(2,5-dimethyl-1,3-oxazole)
• 1375068-54-4(1-(1,3-oxazol-5-yl)methanamine dihydrochloride)