• 1. Excellent energy storage performance in NaNbO3-based relaxor antiferroeic ceramics under a low electric field
  XuxinCheng,XiaomingChen,PengyuanFan
• 2. Enantiomorphic symmetry breaking in crystallization of molten sodium chlorate?
  Martin R. Ward,Gary W. Copeland,Andrew J. Alexander Chem. Commun., 2010,46, 7634-7636
• 3. Excimer–monomer switch: a reaction-based approach for selective detection of fluoride?
  Qiao Song,Angela Bamesberger,Lingyun Yang,Haley Houtwed,Haishi Cao Analyst, 2014,139, 3588-3592
• 4. Enantiopure 2,6-disubstituted piperidines bearing one alkene- or alkyne-containing substituent: preparation and application to total syntheses of indolizidine-alkaloids?
  Hui Liu,Deyong Su,Guolin Cheng,Jimin Xu,Xinyan Wang,Yuefei Hu Org. Biomol. Chem., 2010,8, 1899-1904
• 5. Fate of nitrogen-15 in the subsequent growing season of greenhouse tomato plants (Lycopersicon esculentum Mill) as influenced by alternate partial root-zone irrigation
  Maomao Hou,Fenglin Zhong,Qiu Jin,Enjiang Liu,Jie Feng,Tengyun Wang,Yue Gao RSC Adv., 2017,7, 34392-34400

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines Piperidines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines

(3R)-1-(azetidin-3-yl)-3-fluoro-piperidine: A Comprehensive Overview

(3R)-1-(azetidin-3-yl)-3-fluoro-piperidine, identified by the CAS number 1403769-88-9, is a complex organic compound that has garnered significant attention in the field of medicinal chemistry and pharmacology. This compound, with its unique structural features, has been the subject of extensive research, particularly in the development of novel therapeutic agents. The molecule's structure, which includes a piperidine ring fused with an azetidine moiety and a fluorine substituent, contributes to its potential as a bioactive compound.

The synthesis of (3R)-1-(azetidin-3-yl)-3-fluoro-piperidine involves advanced organic chemistry techniques, including stereocontrolled reactions to ensure the correct configuration at the chiral center. Recent studies have highlighted the importance of stereochemistry in determining the compound's biological activity, making it a valuable tool in enantioselective drug design. Researchers have explored its potential as a precursor for more complex molecules, particularly in the development of GABA receptor modulators and other neuroactive agents.

One of the most promising applications of this compound lies in its role as an intermediate in drug discovery pipelines. By modifying the azetidine and piperidine rings, scientists have been able to create derivatives with enhanced pharmacokinetic properties. For instance, recent research has demonstrated that certain analogs exhibit improved bioavailability and reduced toxicity compared to earlier generations of similar compounds.

The integration of computational chemistry tools has further accelerated the exploration of (3R)-1-(azetidin-3-yl)-3-fluoro-piperidine's potential. Molecular docking studies have revealed that the compound can interact with key residues in various protein targets, suggesting its utility in treating conditions such as epilepsy and anxiety disorders. Additionally, its ability to penetrate the blood-brain barrier makes it a compelling candidate for central nervous system (CNS) drug development.

Recent advancements in synthetic methodology have also expanded the scope of this compound's applications. For example, its use as a building block in click chemistry has enabled rapid assembly of larger molecular frameworks. This approach has been particularly beneficial in high-throughput screening campaigns aimed at identifying novel therapeutic leads.

In conclusion, (3R)-1-(azetidin-3-yl)-3-fluoro-piperidine represents a significant advancement in organic synthesis and drug discovery. Its unique structure, combined with cutting-edge research techniques, positions it as a versatile tool for developing innovative treatments across various therapeutic areas. As ongoing studies continue to uncover new insights into its properties and applications, this compound is poised to play an increasingly important role in modern pharmacology.

• 1378814-67-5(4-(azetidin-1-yl)-3-fluoropiperidine)
• 1403763-26-7((3R)-1-(azetidin-3-yl)-3-fluoro-pyrrolidine;dihydrochloride)
• 194427-25-3(1-(azetidin-3-yl)-4-fluoropiperidine)
• 1257294-15-7((3R)-1-(3-azetidinyl)-3-fluoro-Pyrrolidine)
• 1257294-17-9((3S)-1-(3-azetidinyl)-3-fluoro-Pyrrolidine)
• 194427-15-1(1-(Azetidin-3-yl)-4-fluoropiperidine dihydrochloride)
• 1403766-81-3(1-(azetidin-3-yl)-3-fluoro-pyrrolidine;dihydrochloride)
• 477577-08-5
• 1449117-63-8(1-(Azetidin-3-yl)-4-fluoropiperidine hydrochloride)
• 477577-23-4(1-Piperidineethanamine, 3-fluoro-)