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• 2. Empowering microfluidics by micro-3D printing and solution-based mineral coating?
  Hongxia Li,Aikifa Raza,Qiaoyu Ge,Jin-You Lu,TieJun Zhang Soft Matter, 2020,16, 6841-6849
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Comprehensive Analysis of 2-(1-Hydroxyethyl)pyrimidin-5-ol (CAS No. 1400807-79-5): Properties, Applications, and Industry Insights

2-(1-Hydroxyethyl)pyrimidin-5-ol (CAS No. 1400807-79-5) is a specialized pyrimidine derivative gaining attention in pharmaceutical and agrochemical research due to its unique structural features. This compound, characterized by a hydroxyethyl substitution at the 2-position and a hydroxyl group at the 5-position of the pyrimidine ring, exhibits versatile reactivity, making it a valuable intermediate in synthetic chemistry. Recent studies highlight its potential as a building block for biologically active molecules, particularly in drug discovery targeting enzyme modulation.

The growing demand for heterocyclic compounds like 2-(1-Hydroxyethyl)pyrimidin-5-ol correlates with advancements in precision medicine and green chemistry. Researchers are exploring its application in developing sustainable agrochemicals, aligning with the global push for eco-friendly crop protection solutions. Analytical techniques such as HPLC-MS and NMR spectroscopy confirm its high purity (>98%), a critical factor for regulatory compliance in Good Manufacturing Practice (GMP) environments.

From a molecular perspective, the compound's hydrogen-bonding capacity enables interactions with biological targets, sparking interest in structure-activity relationship (SAR) studies. Computational chemistry models suggest its potential as a kinase inhibitor scaffold, addressing frequent queries about "small molecules for cancer research" in scientific databases. Its solubility profile (water-soluble at pH 4-8) also makes it suitable for formulation development, a trending topic in pharmaceutical technology forums.

Industrial-scale synthesis of CAS 1400807-79-5 employs microwave-assisted reactions, reflecting the industry's shift toward energy-efficient processes. Patent analyses reveal increasing protection for derivatives of this compound in antiviral applications, coinciding with post-pandemic research priorities. Quality control protocols emphasize residual solvent monitoring, particularly for ICH Class 2 solvents, ensuring safety in downstream applications.

Emerging literature discusses the compound's role in metal-organic frameworks (MOFs), answering frequent searches about "pyrimidines in material science." Its thermal stability (decomposition >200°C) enables applications in high-performance polymers, while its fluorescence properties attract attention in sensor development. These multidisciplinary applications position 2-(1-Hydroxyethyl)pyrimidin-5-ol as a compound bridging pharmaceutical and material sciences.

Regulatory databases show 1400807-79-5 as compliant with REACH and TSCA requirements, addressing common compliance queries. Storage recommendations (-20°C under nitrogen) align with best practices for oxygen-sensitive compounds, a frequent concern in research forums. The compound's logP value (predicted 0.82) suggests favorable membrane permeability, explaining its popularity in medicinal chemistry projects.

Recent conference presentations highlight innovative uses of this pyrimidine alcohol in asymmetric catalysis, particularly for chiral drug synthesis. Its compatibility with continuous flow chemistry systems answers industry demands for scalable production methods. Analytical method development papers emphasize UHPLC quantification techniques, reflecting the compound's growing commercial significance.

The environmental fate of 2-(1-Hydroxyethyl)pyrimidin-5-ol has become a research focus, with biodegradation studies showing >60% mineralization in 28 days (OECD 301B). This data supports its inclusion in green chemistry initiatives, a major trend in chemical industry sustainability reports. Life cycle assessment (LCA) models indicate lower carbon footprint compared to analogous halogenated pyrimidines.

Supply chain analyses reveal increasing global availability of CAS 1400807-79-5, with technical specifications varying by supplier. Current market intelligence suggests growing procurement for high-throughput screening libraries, particularly in academic research consortia. The compound's structure-property relationships continue to generate publications in QSAR journals, demonstrating sustained scientific interest.

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