Cas no 139307-94-1 (Guanosine5'-(tetrahydrogen triphosphate), 2'-deoxy-7,8-dihydro-8-oxo-)

Guanosine 5'-(tetrahydrogen triphosphate), 2'-deoxy-7,8-dihydro-8-oxo-, is a modified nucleotide triphosphate analog featuring an 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG) moiety. This compound is structurally distinct due to the oxidative modification at the C8 position of the purine ring, which introduces unique electronic and steric properties. It serves as a valuable tool in studying oxidative DNA damage, repair mechanisms, and mutagenesis, particularly in contexts involving reactive oxygen species (ROS). Its incorporation into oligonucleotides enables research on base excision repair (BER) pathways and polymerase fidelity. The triphosphate form ensures compatibility with enzymatic systems, facilitating in vitro applications such as primer extension assays and structural studies of DNA-protein interactions.
Guanosine5'-(tetrahydrogen triphosphate), 2'-deoxy-7,8-dihydro-8-oxo- structure
139307-94-1 structure
Product Name:Guanosine5'-(tetrahydrogen triphosphate), 2'-deoxy-7,8-dihydro-8-oxo-
CAS No:139307-94-1
MF:C10H16N5O14P3
MW:523.180424690247
CID:168356
PubChem ID:135398565
Update Time:2025-06-08

Guanosine5'-(tetrahydrogen triphosphate), 2'-deoxy-7,8-dihydro-8-oxo- Chemical and Physical Properties

Names and Identifiers

    • Guanosine5'-(tetrahydrogen triphosphate), 2'-deoxy-7,8-dihydro-8-oxo-
    • 2'-Deoxy-8-oxo-7,8-dihydroguanosine 5'-(tetrahydrogen triphosphat e)
    • 2,2,7,7-Tetramethyltricyclo< 6.2.1.03.8> -undecan-4-on
    • 2'-deoxy-7,8-dihydro-8-oxoguanosine-5'-triphosphate
    • 6-methyl-5-phenyl-imidazo[5,1-c][1,4]oxazin-8-one
    • 8-oxo-2'-deoxyguan
    • 8-oxo-2'-deoxyguanosine 5'-triphosphate
    • 8-oxo-7,8-dihydro-2'-deoxyguanosine triphosphate
    • AG-J-75502
    • CTK4J7169
    • CTK6F4822
    • ETHYL 4-METHYL-2-OXO-6-[(Z)-2-PHENYLETHENYL]-3,6-DIHYDRO-1H-PYRIMIDINE-5-CARBOXYLATE
    • EU-0017609
    • Oprea1_193480
    • 8-Oxodeoxyguanosine triphosphate
    • 9-[2-Deoxy-5-O-(hydroxy{[hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl)pentofuranosyl]-2-imino-3,9-dihydro-2H-purine-6,8-diol
    • [[(2R,3S,5R)-5-(2-amino-6,8-dioxo-1,7-dihydropurin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
    • 2'-deoxy-8-oxoguanosine 5'-(tetrahydrogen triphosphate)
    • 8-Oxo-dgtp
    • 7,8-dihydro-8-oxo-2'-deoxyguanosine 5'-(tetrahydrogen triphosphate)
    • CHEBI:63220
    • 139307-94-1
    • 8-oxodGTP
    • 8-hydroxy-2'-deoxyguanosine-5'-triphosphate
    • SCHEMBL154964
    • C19967
    • 8-Oxo-2'-deoxyguanosine triphosphate
    • DTXSID00930434
    • 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE
    • 8DG
    • Q27132486
    • 2'-deoxy-8-oxo-7,8-dihydroguanosine 5'-(tetrahydrogen triphosphate)
    • 8-Oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate
    • [[(2R,3S,5R)-5-(2-amino-6,8-dioxo-3,7-dihydropurin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
    • 8-oxo-7,8-dihydro-2'-dGTP
    • 8-Oxo-deoxyguanosine triphosphate
    • (((((((2R,3S,5R)-5-(6,8-dihydroxy-2-imino-3,9-dihydro-2H-purin-9-yl)-3-hydroxyoxolan-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)phosphonic acid
    • (((((((3S)-5-(6,8-dihydroxy-2-imino-3,9-dihydro-2H-purin-9-yl)-3-hydroxyoxolan-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)phosphonate
    • 7,8-dihydro-8-oxo-2'-dGTP
    • 2'-deoxy-7,8-dihydro-8-oxo-guanosine 5'-triphosphate
    • 2'-deoxy-7,8-dihydro-8-oxo-Guanosine 5'-(tetrahydrogen triphosphate)
    • ({[({[(3S)-5-(6,8-dihydroxy-2-imino-3,9-dihydro-2H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonate
    • ({[({[(2R,3S,5R)-5-(6,8-dihydroxy-2-imino-3,9-dihydro-2H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid
    • Inchi： 1S/C10H16N5O14P3/c11-9-13-7-6(8(17)14-9)12-10(18)15(7)5-1-3(16)4(27-5)2-26-31(22,23)29-32(24,25)28-30(19,20)21/h3-5,16H,1-2H2,(H,12,18)(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,17)/t3-,4+,5+/m0/s1
    • InChI Key： BUZOGVVQWCXXDP-VPENINKCSA-N
    • SMILES： P(=O)(O)(OP(=O)(O)OP(=O)(O)O)OC[C@@H]1[C@H](C[C@H](N2C(NC3C(NC(N)=NC2=3)=O)=O)O1)O

Computed Properties

  • Exact Mass: 520.97512
  • Monoisotopic Mass: 522.991
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 8
  • Hydrogen Bond Acceptor Count: 14
  • Heavy Atom Count: 32
  • Rotatable Bond Count: 8
  • Complexity: 1040
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 3
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: -6.4
  • Topological Polar Surface Area: 289?2

Experimental Properties

  • Density: 2.75
  • Boiling Point: °Cat760mmHg
  • Flash Point: °C
  • Refractive Index: 1.935
  • PSA: 289.76
  • LogP: -1.25850

Guanosine5'-(tetrahydrogen triphosphate), 2'-deoxy-7,8-dihydro-8-oxo- Pricemore >>

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Guanosine5'-(tetrahydrogen triphosphate), 2'-deoxy-7,8-dihydro-8-oxo- Related Literature

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Additional information on Guanosine5'-(tetrahydrogen triphosphate), 2'-deoxy-7,8-dihydro-8-oxo-

Introduction to Guanosine5'-(tetrahydrogen triphosphate), 2'-deoxy-7,8-dihydro-8-oxo- (CAS No. 139307-94-1)

Guanosine5'-(tetrahydrogen triphosphate), 2'-deoxy-7,8-dihydro-8-oxo- is a specialized nucleotide derivative that has garnered significant attention in the field of biochemistry and pharmacology. This compound, identified by its CAS number 139307-94-1, plays a crucial role in cellular metabolism and signaling pathways. Its unique structure, characterized by the presence of a 2'-deoxyribose sugar and a modified guanine base, makes it an intriguing subject for research in various biological contexts.

The compound is particularly notable for its involvement in energy transfer and phosphate group transfer reactions within cells. The tetrahydrogen triphosphate moiety suggests a high-energy phosphate bond, which is essential for driving various biochemical reactions. This feature positions Guanosine5'-(tetrahydrogen triphosphate), 2'-deoxy-7,8-dihydro-8-oxo- as a potential candidate for therapeutic applications, especially in conditions where energy metabolism is impaired.

Recent studies have highlighted the compound's significance in understanding the mechanisms of nucleotide metabolism and its potential role in modulating cellular processes. Research indicates that this nucleotide derivative may influence pathways related to DNA repair, cell proliferation, and stress response. The modified guanine base and the unique sugar moiety contribute to its distinct biochemical properties, making it a valuable tool for investigating the intricate workings of cellular systems.

In the realm of drug development, Guanosine5'-(tetrahydrogen triphosphate), 2'-deoxy-7,8-dihydro-8-oxo-, has been explored as a precursor for synthesizing novel therapeutic agents. Its structural features allow for modifications that can enhance its pharmacological activity. For instance, researchers have investigated its potential in developing treatments for neurological disorders, where nucleotide metabolism plays a critical role. The compound's ability to interact with enzymes involved in energy metabolism also makes it relevant in studying metabolic diseases such as diabetes and obesity.

The synthesis of this compound involves sophisticated chemical methodologies that require precise control over reaction conditions. The incorporation of the 2'-deoxyribose sugar and the modification of the guanine base are critical steps that determine the compound's efficacy. Advanced techniques in organic synthesis and nucleotide chemistry have enabled researchers to produce high-purity samples of Guanosine5'-(tetrahydrogen triphosphate), 2'-deoxy-7,8-dihydro-8-oxo-, facilitating further investigation into its biological activities.

Evidence from preclinical studies suggests that Guanosine5'-(tetrahydrogen triphosphate), 2'-deoxy-7,8-dihydro-8-oxo-, exhibits promising properties as an experimental therapeutic agent. Its ability to modulate key cellular processes has opened new avenues for treating a variety of diseases. For example, studies have shown that it may help in mitigating oxidative stress and enhancing DNA repair mechanisms. These findings underscore the compound's potential as a lead compound for drug discovery initiatives.

The future of research on Guanosine5'-(tetrahydrogen triphosphate), 2'-deoxy-7,8-dihydro-8-oxo-, lies in elucidating its detailed mechanism of action and exploring its interactions with other cellular components. Advanced analytical techniques such as nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry are being employed to gain deeper insights into its structure-function relationships. These studies will not only enhance our understanding of nucleotide metabolism but also pave the way for developing targeted therapies based on this compound.

Collaborative efforts between chemists, biochemists, and pharmacologists are essential to fully harness the therapeutic potential of Guanosine5'-(tetrahydrogen triphosphate), 2'-deoxy-7,8-dihydro-8-oxo-. By integrating knowledge from multiple disciplines, researchers can optimize synthetic routes, develop innovative drug delivery systems, and conduct comprehensive clinical trials. This multidisciplinary approach will be crucial in translating laboratory findings into tangible benefits for patients suffering from metabolic and neurological disorders.

In conclusion, Guanosine5'-(tetrahydrogen triphosphate), 2'-deoxy-7,8-dihydro-8-oxo-, identified by CAS number 139307-94-1, is a fascinating compound with significant implications in biochemistry and medicine. Its unique structural features and biological activities make it a promising candidate for therapeutic applications. Continued research efforts are expected to unlock new insights into cellular processes and develop novel treatments for various diseases.

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