• 1. Examination of ammonia–poly(pyrrole) interactions by piezoelectric and conductivity measurements
  Analyst, 1991,116, 1125-1130
• 2. Excellent kinetics of single-phase Gd-doped ceria fuel electrodes in solid oxide cells?
  Andreas Nenning,Manuel Holzmann,Jürgen Fleig,Alexander K. Opitz Mater. Adv., 2021,2, 5422-5431
• 3. Excellent lithium ion storage property of porous MnCo2O4 nanorods?
  Peiyuan Zeng,Xiaoxiao Wang,Ming Ye,Qiuyang Ma,Jianwen Li,Wanwan Wang,Baoyou Geng,Zhen Fang RSC Adv., 2016,6, 23074-23084
• 4. Emerging investigator series: first-principles and thermodynamics comparison of compositionally-tuned delafossites: cation release from the (001) surface of complex metal oxides?
  Joseph W. Bennett,Diamond T. Jones,Blake G. Hudson,Joshua Melendez-Rivera,Robert J. Hamers,Sara E. Mason Environ. Sci.: Nano, 2020,7, 1642-1651
• 5. Distinct correlation between (CN2)x units and pores: a low-cost method for predesigned wide range control of micropore size of porous carbon?
  Xiaotong Feng,Lei Bian,Jie Ma,Lei Zhou,Xiayan Wang,Guangsheng Guo,Qiaosheng Pu Chem. Commun., 2019,55, 3963-3966

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Pyrazines Pyrazine carboxylic acids and derivatives

Introduction to Methyl 6-Oxo-1,6-dihydropyrazine-2-Carboxylate (CAS No. 13924-98-6)

Methyl 6-oxo-1,6-dihydropyrazine-2-carboxylate (CAS No. 13924-98-6) is a significant compound in the field of chemical and pharmaceutical research. This compound belongs to the class of pyrazine derivatives, which have garnered considerable attention due to their diverse biological activities and potential applications in drug development. The molecular structure of this compound features a pyrazine ring with an oxo group at the 6-position and a carboxylate ester at the 2-position, making it a versatile scaffold for further chemical modifications and biological studies.

The< strong> CAS number 13924-98-6 provides a unique identifier for this compound, ensuring accurate and unambiguous references in scientific literature and patents. This compound has been extensively studied for its pharmacological properties, particularly in the context of antimicrobial, anti-inflammatory, and anticancer applications. The presence of the carboxylate ester group allows for facile derivatization, enabling researchers to explore novel analogs with enhanced biological activity.

In recent years, there has been a growing interest in pyrazine derivatives due to their ability to interact with various biological targets. For instance, studies have shown that compounds similar to methyl 6-oxo-1,6-dihydropyrazine-2-carboxylate can modulate enzyme activity and interfere with pathogenic processes. One notable area of research has focused on its potential as an intermediate in the synthesis of kinase inhibitors, which are crucial in targeted cancer therapies. The oxo group at the 6-position of the pyrazine ring plays a critical role in determining the compound's reactivity and binding affinity to biological targets.

The< strong> pharmacological profile of methyl 6-oxo-1,6-dihydropyrazine-2-carboxylate has been explored through both in vitro and in vivo studies. Researchers have demonstrated its efficacy in reducing inflammation by inhibiting key pro-inflammatory cytokines. Additionally, preliminary studies suggest that this compound may exhibit cytotoxic effects against certain cancer cell lines by disrupting essential cellular pathways. These findings underscore the importance of this compound as a lead molecule for further drug development efforts.

The synthesis of methyl 6-oxo-1,6-dihydropyrazine-2-carboxylate involves multi-step organic reactions that highlight the compound's synthetic utility. The carboxylate ester can be hydrolyzed to form the corresponding carboxylic acid or converted into other functional groups such as amides or acyl chlorides. This flexibility makes it an attractive building block for medicinal chemists seeking to design novel therapeutic agents. Recent advances in synthetic methodologies have further streamlined the preparation of this compound, allowing for higher yields and purities suitable for preclinical studies.

In addition to its pharmacological applications, methyl 6-oxo-1,6-dihydropyrazine-2-carboxylate has found utility in chemical research as a precursor for more complex heterocyclic systems. The pyrazine core is a privileged scaffold in medicinal chemistry due to its prevalence in biologically active molecules. By modifying various substituents on the pyrazine ring, researchers can fine-tune the electronic and steric properties of the molecule, thereby influencing its biological activity. This approach has led to the discovery of several promising drug candidates with improved pharmacokinetic profiles.

The< strong> role of computational chemistry has been instrumental in understanding the structure-activity relationships (SAR) of methyl 6-oxo-1,6-dihydropyrazine-2-carboxylate and its derivatives. Molecular modeling techniques have provided insights into how different substituents affect binding affinity to biological targets such as enzymes and receptors. These computational studies have guided experimental efforts by predicting optimal modifications that could enhance potency and selectivity. As computational methods continue to evolve, they are expected to play an even greater role in accelerating drug discovery pipelines.

In conclusion, methyl 6-oxo-1,6-dihydropyrazine-2-carboxylate (CAS No. 13924-98-6) is a versatile compound with significant potential in pharmaceutical research. Its unique structural features make it an excellent candidate for developing new drugs targeting various diseases. The growing body of research on this compound highlights its importance as both a synthetic intermediate and a lead molecule for drug discovery efforts. As our understanding of its pharmacological properties continues to expand, so too will its applications in medicine and biotechnology.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)