• 1. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
  Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
• 2. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
  Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293
• 3. Evidence for the intrinsic nature of band-gap states electrochemically observed on atomically flat TiO2(110) surfaces?
  Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789
• 4. Fe3O4 nanoclusters highly dispersed on a porous graphene support as an additive for improving the hydrogen storage properties of LiBH4?
  Guang Xu,Wei Zhang,Ying Zhang,Xiaoxia Zhao,Ping Wen,Di Ma RSC Adv., 2018,8, 19353-19361
• 5. Estimation of activation energy for electroporation and pore growth rate in liquid crystalline and gel phases of lipid bilayers using molecular dynamics simulations?
  Amit Kumar Majhi,Subbarao Kanchi,V. Venkataraman,K. G. Ayappa,Prabal K. Maiti Soft Matter, 2015,11, 8632-8640

Research Brief on 2-Amino-6-Bromoimidazo[1,2-a]Pyridine Hydrochloride (CAS: 1392102-12-3): Recent Advances and Applications

2-Amino-6-Bromoimidazo[1,2-a]Pyridine Hydrochloride (CAS: 1392102-12-3) is a heterocyclic compound of significant interest in the field of chemical biology and pharmaceutical research. This compound, characterized by its imidazopyridine core and bromo-substituent, has emerged as a versatile scaffold in drug discovery, particularly in the development of kinase inhibitors and other therapeutic agents. Recent studies have highlighted its potential in targeting various disease pathways, making it a focal point for ongoing research.

One of the key areas of investigation involves the compound's role as a building block for small-molecule inhibitors. A 2023 study published in the Journal of Medicinal Chemistry demonstrated its utility in synthesizing potent inhibitors of protein kinases, which are critical targets in cancer therapy. The bromo-substituent at the 6-position allows for further functionalization, enabling the development of derivatives with enhanced selectivity and efficacy. Researchers have successfully utilized this compound to create analogs that exhibit nanomolar activity against specific kinase isoforms, underscoring its importance in structure-activity relationship (SAR) studies.

In addition to its applications in oncology, 2-Amino-6-Bromoimidazo[1,2-a]Pyridine Hydrochloride has shown promise in infectious disease research. A recent preprint on bioRxiv detailed its incorporation into novel antimicrobial agents targeting bacterial efflux pumps. The study reported that derivatives of this compound displayed synergistic effects with existing antibiotics, potentially overcoming resistance mechanisms in multidrug-resistant pathogens. This finding opens new avenues for combating antimicrobial resistance, a pressing global health challenge.

The synthetic accessibility of 2-Amino-6-Bromoimidazo[1,2-a]Pyridine Hydrochloride has also been a subject of optimization. A 2024 paper in Organic Process Research & Development described a scalable, high-yield synthesis route that reduces production costs while maintaining purity standards. This advancement is particularly relevant for industrial-scale applications, where cost-effective and sustainable manufacturing processes are paramount. The reported method employs green chemistry principles, minimizing hazardous waste and energy consumption.

Looking ahead, researchers are exploring the compound's potential in neurological disorders. Preliminary data from in vitro models suggest that certain derivatives may modulate neurotransmitter receptors implicated in neurodegenerative diseases. While these findings are still in early stages, they highlight the compound's versatility and the breadth of its possible therapeutic applications. Future studies are expected to elucidate its mechanisms of action and optimize its pharmacokinetic properties for clinical translation.

In conclusion, 2-Amino-6-Bromoimidazo[1,2-a]Pyridine Hydrochloride (CAS: 1392102-12-3) continues to be a valuable tool in medicinal chemistry, with recent research expanding its applications across multiple therapeutic areas. Its structural features enable diverse chemical modifications, making it a cornerstone for developing next-generation therapeutics. As investigations progress, this compound is poised to contribute significantly to addressing unmet medical needs in oncology, infectious diseases, and beyond.

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