• 1. An inter-tangled network of redox-active and conducting polymers as a cathode for ultrafast rechargeable batteries
  Jieun Kim,Han-Saem Park,Tae-Hee Kim,Sung Yeol Kim,Hyun-Kon Song Phys. Chem. Chem. Phys., 2014,16, 5295-5300
• 2. An integrated microfluidic platform for sensitive and rapid detection of biological toxins?
  Robert J. Meagher,Anson V. Hatch,Ronald F. Renzi,Anup K. Singh Lab Chip, 2008,8, 2046-2053
• 3. An assay for the enzyme N-acetyl-β-d-glucosaminidase (NAGase) based on electrochemical detection using screen-printed carbon electrodes (SPCEs)
  R. M. Pemberton,J. P. Hart,T. T. Mottram Analyst, 2001,126, 1866-1871
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  Kanjun Sun,Fengting Hua,Shuzhen Cui,Yanrong Zhu,Hui Peng,Guofu Ma RSC Adv., 2021,11, 37631-37642
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  Muniyandi Sankaralingam,So Hyun Jeon,Yong-Min Lee,Mi Sook Seo,Wonwoo Nam Dalton Trans., 2016,45, 376-383

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Halopyridines Polyhalopyridines

Comprehensive Overview of 4-Chloro-5-fluoro-2-propylpyridine (CAS No. 139161-27-6)

4-Chloro-5-fluoro-2-propylpyridine (CAS No. 139161-27-6) is a halogenated pyridine derivative that has garnered significant attention in pharmaceutical and agrochemical research. This compound, characterized by its unique chloro and fluoro substitutions, serves as a critical intermediate in the synthesis of bioactive molecules. Its molecular structure, combining a pyridine ring with alkyl and halogen functional groups, makes it a versatile building block for drug discovery and material science applications.

In recent years, the demand for fluorinated pyridines like 4-Chloro-5-fluoro-2-propylpyridine has surged due to their enhanced metabolic stability and bioavailability. Researchers are particularly interested in its potential role in developing next-generation pharmaceuticals, including kinase inhibitors and antimicrobial agents. The compound's CAS No. 139161-27-6 is frequently searched in scientific databases, reflecting its relevance in medicinal chemistry and organic synthesis.

One of the trending topics in the field is the application of halogenated heterocycles in sustainable chemistry. 4-Chloro-5-fluoro-2-propylpyridine aligns with this trend, as its synthetic routes are being optimized for green chemistry principles, such as reduced solvent waste and catalytic efficiency. This focus on sustainability resonates with the broader scientific community's push toward eco-friendly synthesis methods.

The compound's physicochemical properties, including its lipophilicity and electronic effects, are key factors driving its utility in drug design. Its chloro and fluoro substituents contribute to its ability to modulate molecular interactions, making it a valuable scaffold for structure-activity relationship (SAR) studies. These attributes are frequently discussed in forums and publications focused on rational drug discovery.

Another area of interest is the compound's role in agrochemical innovation. 4-Chloro-5-fluoro-2-propylpyridine is explored as a precursor for crop protection agents, leveraging its halogenated structure to enhance pesticidal activity. This application aligns with global efforts to address food security challenges through advanced chemical solutions.

From a technical perspective, the synthesis of 4-Chloro-5-fluoro-2-propylpyridine involves multi-step organic reactions, including halogenation and alkylation processes. Researchers often search for optimized protocols to improve yield and purity, highlighting the compound's industrial relevance. Its CAS No. 139161-27-6 is a common query in chemical supplier databases, underscoring its commercial demand.

In summary, 4-Chloro-5-fluoro-2-propylpyridine (CAS No. 139161-27-6) is a multifaceted compound with broad applications in pharmaceuticals, agrochemicals, and material science. Its unique structural features and alignment with sustainability trends make it a subject of ongoing research and innovation. As the scientific community continues to explore its potential, this compound remains a cornerstone in the development of next-generation chemical entities.

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