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  Felix Witte,Philipp Rietsch,Nithiya Nirmalananthan-Budau,Florian Weigert,Jan P. G?tze,Ute Resch-Genger,Siegfried Eigler,Beate Paulus Phys. Chem. Chem. Phys., 2021,23, 17521-17529
• 2. An investigation on the second-order nonlinear optical response of cationic bipyridine or phenanthroline iridium(iii) complexes bearing cyclometallated 2-phenylpyridines with a triphenylamine substituent?
  David B. Cordes,Alexandra M. Z. Slawin,Stefania Righetto,Denis Jacquemin,Eli Zysman-Colman,Véronique Guerchais Dalton Trans., 2018,47, 8292-8300
• 3. An integrated process of CO2 capture and in situ hydrogenation to formate using a tunable ethoxyl-functionalized amidine and Rh/bisphosphine system?
  Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002
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  Bidyut Kumar Kundu,Rinky Singh,Ritudhwaj Tiwari,Debasis Nayak New J. Chem., 2019,43, 4867-4877
• 5. An arsenic trioxide nanoparticle prodrug (ATONP) potentiates a therapeutic effect on an aggressive hepatocellular carcinoma model via enhancement of intratumoral arsenic accumulation and disturbance of the tumor microenvironment?
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• Solvents and Organic Chemicals Organic Compounds Phenylpropanoids and polyketides Stilbenes Stilbenes
• Solvents and Organic Chemicals Organic Compounds Phenylpropanoids and polyketides Stilbenes
• Solvents and Organic Chemicals Organic Compounds Alcohol/Ether

Recent Advances in the Study of 1,3-Benzenediol,5-[2-(4-hydroxy-3-methoxyphenyl) ethyl]- (CAS: 139101-67-0)

The compound 1,3-Benzenediol,5-[2-(4-hydroxy-3-methoxyphenyl) ethyl]-, with the CAS number 139101-67-0, has garnered significant attention in recent years due to its potential applications in chemical biology and pharmaceutical research. This phenolic compound, structurally related to natural polyphenols such as resveratrol and curcumin, exhibits a range of biological activities, including antioxidant, anti-inflammatory, and potential anticancer properties. Recent studies have focused on elucidating its molecular mechanisms, optimizing its synthesis, and exploring its therapeutic potential.

A 2023 study published in the Journal of Medicinal Chemistry investigated the antioxidant properties of 1,3-Benzenediol,5-[2-(4-hydroxy-3-methoxyphenyl) ethyl]- using in vitro and in vivo models. The researchers demonstrated that the compound effectively scavenges reactive oxygen species (ROS) and upregulates endogenous antioxidant enzymes such as superoxide dismutase (SOD) and catalase. These findings suggest its potential as a therapeutic agent for oxidative stress-related diseases, including neurodegenerative disorders and cardiovascular diseases.

Another significant advancement was reported in a 2024 paper in Bioorganic & Medicinal Chemistry Letters, which explored the anti-inflammatory effects of this compound. The study revealed that it inhibits the NF-κB signaling pathway, a key regulator of inflammation, by suppressing the phosphorylation of IκBα. This mechanism was further validated in a murine model of colitis, where the compound significantly reduced inflammatory markers and improved histological scores. These results highlight its potential as a novel anti-inflammatory agent.

In the realm of oncology, a recent preprint (2024) from a research group at the University of Cambridge investigated the anticancer properties of 1,3-Benzenediol,5-[2-(4-hydroxy-3-methoxyphenyl) ethyl]-. The study employed high-throughput screening and molecular docking to identify its interactions with key oncogenic targets, including PI3K and mTOR. Preliminary results indicated that the compound induces apoptosis in cancer cell lines by activating caspase-3 and PARP cleavage. These findings open new avenues for its development as a targeted therapy for certain cancers.

From a synthetic chemistry perspective, a 2023 article in Organic & Biomolecular Chemistry presented an optimized route for the large-scale synthesis of 1,3-Benzenediol,5-[2-(4-hydroxy-3-methoxyphenyl) ethyl]-. The authors developed a green chemistry approach using biocatalysis, which improved yield and reduced environmental impact compared to traditional methods. This advancement is critical for facilitating further preclinical and clinical studies.

Despite these promising developments, challenges remain in the clinical translation of 1,3-Benzenediol,5-[2-(4-hydroxy-3-methoxyphenyl) ethyl]-. Pharmacokinetic studies, as reported in a 2024 issue of Drug Metabolism and Disposition, indicate that the compound has limited oral bioavailability due to rapid metabolism. Researchers are now exploring prodrug strategies and nanoparticle-based delivery systems to overcome this limitation.

In conclusion, recent research on 1,3-Benzenediol,5-[2-(4-hydroxy-3-methoxyphenyl) ethyl]- (CAS: 139101-67-0) has significantly advanced our understanding of its biological activities and therapeutic potential. While challenges in drug development persist, the compound's multifaceted pharmacological profile makes it a promising candidate for further investigation in the fields of oxidative stress, inflammation, and oncology. Future studies should focus on improving its pharmacokinetic properties and validating its efficacy in advanced disease models.

• 60640-97-3(1,3-Benzenediol, 5-[2-(3-hydroxy-4-methoxyphenyl)ethyl]-)
• 108853-14-1(dendrophenol)
• 116518-76-4(1,2-Benzenediol,4-[2-(3,4,5-trimethoxyphenyl)ethyl]-)
• 108853-12-9(Phenol,4-[2-(3-hydroxyphenyl)ethyl]-2,6-dimethoxy-)
• 108853-09-4(Benzene,5-[2-(3,4-dimethoxyphenyl)ethyl]-1,2,3-trimethoxy-)
• 6766-82-1(2,6-dimethoxy-4-propylphenol)
• 149329-84-0(Phenol,3,3'-(1,2-ethanediyl)bis[5,6-dimethoxy-)
• 95041-90-0(Erianin)
• 111394-46-8(Phenol,5-[2-(3-hydroxy-4-methoxyphenyl)ethyl]-2,3-dimethoxy-)
• 101508-50-3(Phenol,2-methoxy-4-[2-(3,4,5-trimethoxyphenyl)ethyl]-)