• 1. An artificial enzyme cascade amplification strategy for highly sensitive and specific detection of breast cancer-derived exosomes?
  Huiying Xu,Lu Zheng,Yu Zhou,Bang-Ce Ye Analyst, 2021,146, 5542-5549
• 2. An algal process treatment combined with the Fenton reaction for high concentrations of amoxicillin and cefradine
  Haitao Li,Yu Pan,Zhizhi Wang,Shan Chen,Ruixin Guo,Jianqiu Chen RSC Adv., 2015,5, 100775-100782
• 3. An amide probe as a selective Al3+ and Fe3+ sensor inside the HeLa and a549 cell lines: Pictet–Spengler reaction for the rapid detection of tryptophan amino acid?
  Bidyut Kumar Kundu,Rinky Singh,Ritudhwaj Tiwari,Debasis Nayak New J. Chem., 2019,43, 4867-4877
• 4. An apparatus for testing water by measurement of its electrical conductivity
  Analyst, 1912,37, 538-543
• 5. An artificial photosynthesis system comprising a covalent triazine framework as an electron relay facilitator for photochemical carbon dioxide reduction?
  Siquan Zhang,Shengyao Wang,Liping Guo,Hao Chen,Bien Tan,Shangbin Jin J. Mater. Chem. C, 2020,8, 192-200

4-Fluoro-3-(Trifluoromethyl)phenyl Isocyanate: An Overview of Its Properties and Applications

4-Fluoro-3-(trifluoromethyl)phenyl isocyanate (CAS No. 139057-86-6) is a versatile organic compound that has garnered significant attention in the fields of chemical synthesis, pharmaceutical research, and materials science. This compound is characterized by its unique structure, which includes a fluoro-substituted benzene ring and a trifluoromethyl group, making it an attractive building block for various applications.

The molecular formula of 4-Fluoro-3-(trifluoromethyl)phenyl isocyanate is C₉H₄F₄N₂O, and its molecular weight is approximately 216.13 g/mol. The presence of the isocyanate functional group (NCO) endows this compound with high reactivity, enabling it to participate in a wide range of chemical reactions, particularly in the formation of urethanes and ureas. These derivatives are crucial in the development of polymers, coatings, and adhesives.

In the context of pharmaceutical research, 4-Fluoro-3-(trifluoromethyl)phenyl isocyanate has been explored for its potential in drug discovery and development. The fluorine and trifluoromethyl groups contribute to the compound's lipophilicity and metabolic stability, which are desirable properties for drug candidates. Recent studies have shown that derivatives of this compound exhibit promising biological activities, including anti-inflammatory, antiviral, and anticancer properties.

A notable example of its application in drug discovery is the synthesis of novel small molecules targeting specific protein-protein interactions (PPIs). PPIs are critical for many cellular processes, and their modulation can lead to therapeutic benefits. Researchers have utilized 4-Fluoro-3-(trifluoromethyl)phenyl isocyanate as a key intermediate in the design of inhibitors that disrupt specific PPIs involved in disease pathways. For instance, a study published in the Journal of Medicinal Chemistry reported the successful synthesis of a series of compounds derived from 4-Fluoro-3-(trifluoromethyl)phenyl isocyanate, which demonstrated potent inhibition of a key enzyme implicated in cancer progression.

Beyond pharmaceutical applications, 4-Fluoro-3-(trifluoromethyl)phenyl isocyanate has also found use in materials science. Its reactivity with various nucleophiles allows for the formation of functionalized polymers with tailored properties. These polymers can be designed to exhibit enhanced mechanical strength, thermal stability, and chemical resistance, making them suitable for advanced applications such as coatings, adhesives, and composites.

In the realm of polymer chemistry, researchers have explored the use of 4-Fluoro-3-(trifluoromethyl)phenyl isocyanate in the synthesis of polyurethanes with improved performance characteristics. A study published in Polymer Chemistry highlighted the synthesis of polyurethane elastomers using this compound as a chain extender. The resulting materials exhibited excellent mechanical properties and were found to be highly resistant to environmental degradation.

The versatility of 4-Fluoro-3-(trifluoromethyl)phenyl isocyanate extends to its use as a reagent in organic synthesis. Its ability to form stable urethane linkages makes it a valuable tool for constructing complex molecular architectures. In synthetic chemistry, this compound has been employed in the preparation of multifunctional ligands for catalysis and coordination chemistry. A recent publication in Organic Letters described the synthesis of a series of ligands derived from 4-Fluoro-3-(trifluoromethyl)phenyl isocyanate, which were used to develop highly efficient catalysts for asymmetric reactions.

In summary, 4-Fluoro-3-(trifluoromethyl)phenyl isocyanate (CAS No. 139057-86-6) is a multifaceted compound with a wide range of applications across various scientific disciplines. Its unique structural features and high reactivity make it an essential building block for advanced materials and pharmaceuticals. Ongoing research continues to uncover new possibilities for this compound, further solidifying its importance in modern chemistry.

• 69922-27-6(2-Fluoro-5-(trifluoromethyl)phenyl isocyanate)
• 123950-44-7(3,5-Difluoro-4-(trifluoromethyl)aniline)
• 351003-65-1(4-Fluoro-3-methylphenyl Isocyanate)
• 190774-52-8(2-Fluoro-3-(trifluoromethyl)phenyl Isocyanate)
• 302912-43-2(4-Fluoro-3-(trifluoromethyl)phenyl Isothiocyanate)
• 69411-68-3(3-fluoro-4-(trifluoromethyl)aniline)
• 16588-74-2(1-isocyanato-3,5-bis(trifluoromethyl)benzene)
• 2357-47-3(5-Amino-2-fluorobenzotrifluoride)
• 302912-19-2(3-Fluoro-5-trifluoromethylphenyl isocyanate)
• 139185-13-0(Benzenamine, 4-fluoro-3-(trifluoromethyl)-, hydrochloride)