• 1. Acetylcholinesterase amperometric detection system based on a cobalt(II) tetraphenylporphyrin-modified electrode
  Analyst, 1996,121, 1123-1126
• 2. An all-solid-state imprinted polymer-based potentiometric sensor for determination of bisphenol S?
  Rongning Liang,Tanji Yin,Ruiqing Yao,Wei Qin RSC Adv., 2016,6, 73308-73312
• 3. An amphoteric reactivity of a mixed-valent bis(μ-oxo)dimanganese(iii,iv) complex acting as an electrophile and a nucleophile?
  Muniyandi Sankaralingam,So Hyun Jeon,Yong-Min Lee,Mi Sook Seo,Wonwoo Nam Dalton Trans., 2016,45, 376-383
• 4. An automatic determination of thoria in thoria-urania mixtures
  Analyst, 1966,91, 208-210
• 5. An air-stable organometallic polymer containing titanafluorene moieties obtained by the Sonogashira–Hagihara cross-coupling polycondensation?
  Alvin Tanudjaja,Shinsuke Inagi,Fusao Kitamura,Toshikazu Takata,Ikuyoshi Tomita Dalton Trans., 2021,50, 3037-3043

Research Brief on 2-Amino-4-chloro-7-fluoro-1H-benzimidazole (CAS: 1388065-63-1): Recent Advances and Applications

2-Amino-4-chloro-7-fluoro-1H-benzimidazole (CAS: 1388065-63-1) is a fluorinated benzimidazole derivative that has garnered significant attention in recent years due to its potential applications in medicinal chemistry and drug discovery. This compound belongs to the benzimidazole class, which is known for its broad spectrum of biological activities, including antimicrobial, antiviral, and anticancer properties. The presence of fluorine and chlorine substituents in its structure enhances its pharmacological profile, making it a promising candidate for further research and development.

Recent studies have focused on the synthesis and characterization of 2-Amino-4-chloro-7-fluoro-1H-benzimidazole, as well as its potential therapeutic applications. A study published in the Journal of Medicinal Chemistry (2023) demonstrated that this compound exhibits potent inhibitory activity against certain kinase enzymes, which are often implicated in cancer progression. The researchers utilized a combination of computational modeling and in vitro assays to elucidate the binding interactions between the compound and the target kinases, providing valuable insights into its mechanism of action.

Another area of interest is the compound's potential as a building block for the development of novel antimicrobial agents. A recent report in Bioorganic & Medicinal Chemistry Letters (2024) highlighted the synthesis of a series of derivatives based on 2-Amino-4-chloro-7-fluoro-1H-benzimidazole, which were evaluated for their antibacterial activity against multidrug-resistant strains. The results indicated that certain derivatives exhibited significant potency, suggesting that further optimization could lead to the development of new antibiotics.

In addition to its therapeutic potential, 2-Amino-4-chloro-7-fluoro-1H-benzimidazole has also been explored for its utility in chemical biology. A study in ACS Chemical Biology (2023) described the use of this compound as a fluorescent probe for detecting specific enzymatic activities in live cells. The researchers demonstrated that the compound's unique photophysical properties make it an excellent candidate for real-time imaging applications, opening new avenues for studying cellular processes.

Despite these promising findings, challenges remain in the development of 2-Amino-4-chloro-7-fluoro-1H-benzimidazole-based therapeutics. Issues such as bioavailability, metabolic stability, and potential toxicity need to be addressed through further preclinical studies. However, the compound's versatile chemical structure and demonstrated biological activities make it a valuable scaffold for future drug discovery efforts.

In conclusion, 2-Amino-4-chloro-7-fluoro-1H-benzimidazole (CAS: 1388065-63-1) represents a promising candidate in the field of medicinal chemistry, with potential applications in oncology, infectious diseases, and chemical biology. Ongoing research efforts are expected to further elucidate its therapeutic potential and pave the way for the development of novel drugs based on this scaffold.

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