Cas no 13880-05-2 (N-(1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)acrylamide)

N-(1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)acrylamide is a multifunctional acrylamide derivative characterized by its hydrophilic hydroxyl groups and reactive acrylamide moiety. This compound is particularly valuable in polymer chemistry, where its polyfunctional structure enables crosslinking and modification of polymer networks, enhancing mechanical properties and water solubility. The presence of three hydroxyl groups facilitates hydrogen bonding and compatibility with aqueous systems, making it suitable for hydrogels, adhesives, and coatings. Its acrylamide group allows for radical polymerization, enabling covalent incorporation into polymeric matrices. The compound’s balanced reactivity and hydrophilicity make it a versatile intermediate for synthesizing advanced functional materials with tailored properties.
N-(1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)acrylamide structure
13880-05-2 structure
Product Name:N-(1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)acrylamide
CAS No:13880-05-2
MF:C7H13NO4
MW:175.182422399521
MDL:MFCD00081045
CID:49528
PubChem ID:24862471
Update Time:2025-06-08

N-(1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)acrylamide Chemical and Physical Properties

Names and Identifiers

    • N-(1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)acrylamide
    • N-[Tris(hydroxymethyl)methyl]acrylamide
    • N-ACRYLOYLTRIS(HYDROXYMETHYL)AMINOMETHANE
    • N-[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]prop-2-enamide
    • NAT,TRIS-acrylamide
    • NAT
    • N-[2-Hydroxy-1,1-bis(hydroxymethyl)ethyl]acrylamide
    • ACRYLAMIDOTRISHYDROXYMETHYLMETHANE
    • N-(1,3-Dihydroxy-2-(hydroxymethyl)
    • Acryloylaminomethylidynetrimethanol
    • 2-ACRYLAMIDO-2-HYDROXYMETHYL-1,3-PROPANEDIOL
    • N-[1,1-Di(hydroxymethyl)-2-hydroxyethyl]acrylamide
    • NAT, TRIS-acrylamide
    • N-[Tris(hydroxymethyl)methyl]acrylamide,98%
    • TRIS-acrylamide
    • N-Acryloyl-tris(hydroxymethyl)aminomethane
    • N-[Tris(hydroxymethyl)methyl)acrylamide
    • zlchem 121
    • ZLB0110
    • n-[1,3-dihydroxy-2-(hydroxymethyl)-2-propanyl]acrylamide
    • Acrylamidotris(hydroxymethyl)methane
    • AK
    • 2-Propenamide, N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-
    • tris(hydroxymethyl)acrylaminomethane
    • 2-Propenamide, N-(2-hydroxy-1,1-bis(hydroxymethyl)ethyl)-
    • N-[Tris(hydroxymethyl)methyl]acrylamide, contains <=7% KCl, 93%
    • CS-0158040
    • UNII-R8VGY8CVF2
    • J-007179
    • N-(2-HYDROXY-1,1-BIS(HYDROXYMETHYL)ETHYL)-2-PROPENAMIDE
    • FT-0636974
    • SCHEMBL105869
    • STR02781
    • 30347-69-4
    • DTXSID60160790
    • n-[tris(hydroxymethyl)methyl]-acrylamide
    • N-(2-Hydroxy-1,1-bis(hydroxymethyl)ethyl)acrylamide
    • EINECS 237-645-4
    • 13880-05-2
    • MFCD00081045
    • C93420
    • NS00024490
    • AKOS015900619
    • R8VGY8CVF2
    • DTXCID7083281
    • Tris-A
    • NATHMA
    • DB-042445
    • MDL： MFCD00081045
    • Inchi： 1S/C7H13NO4/c1-2-6(12)8-7(3-9,4-10)5-11/h2,9-11H,1,3-5H2,(H,8,12)
    • InChI Key： MVBJSQCJPSRKSW-UHFFFAOYSA-N
    • SMILES： OCC(CO)(CO)NC(C=C)=O

Computed Properties

  • Exact Mass: 175.08400
  • Monoisotopic Mass: 175.084
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 4
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 12
  • Rotatable Bond Count: 5
  • Complexity: 157
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: 2
  • XLogP3: -2
  • Topological Polar Surface Area: 89.8

Experimental Properties

  • Color/Form: powder
  • Density: 1.3±0.1 g/cm3
  • Melting Point: 136-141?°C (lit.)
  • Boiling Point: 510.8 ℃ at 760 mmHg
  • Flash Point: 262.7±30.1 °C
  • Refractive Index: 1.528
  • Water Partition Coefficient: Soluble in water.
  • PSA: 89.79000
  • LogP: -1.60480
  • Sensitiveness: Light Sensitive & Hygroscopic
  • Solubility: Not determined
  • Vapor Pressure: 0.0±3.0 mmHg at 25°C

N-(1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)acrylamide Security Information

  • Symbol: GHS07
  • Signal Word：Warning
  • Hazard Statement： H315-H319-H335
  • Warning Statement： P261-P305+P351+P338
  • Hazardous Material transportation number：NONH for all modes of transport
  • WGK Germany：3
  • Hazard Category Code： 36/37/38
  • Safety Instruction： S26-S37/39
  • FLUKA BRAND F CODES：8-10-21
  • Hazardous Material Identification： Xi
  • Storage Condition：2-8°C
  • Risk Phrases：R36/37/38

N-(1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)acrylamide Customs Data

  • HS CODE：2924199090
  • Customs Data：

    China Customs Code:

    2924199090

    Overview:

    2924199090. Other acyclic amides(Including acyclic carbamates)(Including its derivatives and salts). VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to, packing

    Summary:

    2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

N-(1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)acrylamide Pricemore >>

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N-(1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)acrylamide Suppliers

Amadis Chemical Company Limited
Gold Member
Audited Supplier Audited Supplier
(CAS:13880-05-2)N-(1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)acrylamide
Order Number:A807443
Stock Status:in Stock
Quantity:25g/100g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 04:47
Price ($):165.0/512.0

N-(1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)acrylamide Related Literature

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Additional information on N-(1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)acrylamide

Recent Advances in N-(1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)acrylamide (CAS 13880-05-2) Research

N-(1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)acrylamide (CAS 13880-05-2) is a multifunctional acrylamide derivative that has garnered significant attention in the fields of polymer chemistry, biomaterials, and drug delivery systems. Recent studies have explored its unique chemical properties, including its ability to form hydrogels with tunable mechanical properties and biocompatibility, making it a promising candidate for biomedical applications.

One of the most notable advancements in the research of this compound is its application in the development of smart hydrogels for controlled drug release. A 2023 study published in the Journal of Controlled Release demonstrated that hydrogels synthesized using N-(1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)acrylamide exhibited pH-responsive behavior, enabling targeted drug delivery in tumor microenvironments. The study reported a significant enhancement in the therapeutic efficacy of anticancer drugs when delivered via these hydrogels.

In addition to drug delivery, this compound has been investigated for its role in tissue engineering. Researchers have utilized its crosslinking properties to create scaffolds that support cell adhesion and proliferation. A recent study in Biomaterials Science highlighted the successful use of these scaffolds in cartilage regeneration, showcasing the compound's potential in regenerative medicine.

Another area of interest is the compound's application in biosensors. Due to its ability to form stable networks with other polymers, N-(1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)acrylamide has been incorporated into sensor matrices to improve their sensitivity and stability. A 2024 publication in Analytical Chemistry reported the development of a glucose biosensor with enhanced performance, attributed to the incorporation of this acrylamide derivative.

Despite these promising developments, challenges remain in the large-scale production and clinical translation of products derived from N-(1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)acrylamide. Issues such as batch-to-batch variability and long-term stability under physiological conditions need to be addressed. Ongoing research is focused on optimizing synthesis protocols and conducting comprehensive in vivo studies to ensure safety and efficacy.

In conclusion, N-(1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)acrylamide (CAS 13880-05-2) represents a versatile building block for advanced biomedical applications. Its unique chemical structure and functional properties continue to inspire innovative research, paving the way for breakthroughs in drug delivery, tissue engineering, and biosensing technologies.

13880-05-2 (N-(1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)acrylamide) Related Products

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Amadis Chemical Company Limited
(CAS:13880-05-2)N-(1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)acrylamide
A807443
Purity:99%/99%
Quantity:25g/100g
Price ($):165.0/512.0
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