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Comprehensive Overview of 4-Chloro-[3,4]bipyridinyl-2-ylamine (CAS No. 1381938-46-0): Properties, Applications, and Research Insights

4-Chloro-[3,4]bipyridinyl-2-ylamine (CAS No. 1381938-46-0) is a specialized bipyridine derivative that has garnered significant attention in pharmaceutical and agrochemical research due to its unique molecular structure. The compound features a chloro-substituted bipyridine core, which enhances its reactivity and binding affinity in various chemical interactions. Researchers are particularly interested in its potential as a building block for synthesizing novel heterocyclic compounds, which are pivotal in drug discovery and material science.

In recent years, the demand for high-purity intermediates like 4-Chloro-[3,4]bipyridinyl-2-ylamine has surged, driven by advancements in catalysis and medicinal chemistry. Its role in facilitating cross-coupling reactions—such as Suzuki-Miyaura or Buchwald-Hartwig reactions—makes it invaluable for constructing complex molecular architectures. This aligns with the growing trend of green chemistry, where efficient synthetic routes minimize waste and energy consumption. Laboratories and industries increasingly prioritize such compounds to meet sustainability goals while maintaining high yields.

From a biological activity perspective, 4-Chloro-[3,4]bipyridinyl-2-ylamine has shown promise in preliminary studies targeting enzyme inhibition and receptor modulation. Its structural similarity to known pharmacophores has led to investigations into its potential applications in central nervous system (CNS) disorders and anti-inflammatory therapies. These studies often leverage computational tools like molecular docking to predict interactions, reflecting the integration of AI-driven drug design in modern research.

The compound’s physicochemical properties, including solubility, stability, and partition coefficient (logP), are critical for formulation scientists. For instance, its moderate lipophilicity suggests suitability for blood-brain barrier penetration, a key factor in CNS drug development. Such data is frequently sought by researchers optimizing drug delivery systems, especially for neurodegenerative diseases—a hot topic in 2024 due to rising global prevalence.

Beyond pharmaceuticals, 4-Chloro-[3,4]bipyridinyl-2-ylamine is explored in material science for designing organic semiconductors and ligands for metal-organic frameworks (MOFs). Its conjugated system and electron-rich nitrogen atoms make it a candidate for optoelectronic devices, aligning with the push for renewable energy technologies. This versatility addresses common search queries like “bipyridine applications in solar cells” or “nitrogen heterocycles in MOFs.”

Quality control and analytical methods for CAS No. 1381938-46-0 are another focal point. Techniques like HPLC, LC-MS, and NMR spectroscopy ensure batch consistency, a priority for regulatory compliance. Discussions on patent landscapes and synthetic routes further highlight its commercial relevance, often appearing in forums on process chemistry optimization.

In summary, 4-Chloro-[3,4]bipyridinyl-2-ylamine exemplifies the intersection of cutting-edge research and industrial utility. Its multifaceted applications—from drug discovery to advanced materials—underscore why it remains a highly searched compound in scientific databases. As interdisciplinary collaborations expand, its role in addressing global challenges like healthcare innovation and sustainable technology will likely grow.

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