• 1. Evidence of rutile-to-anatase photo-induced electron transfer in mixed-phase TiO2 by solid-state NMR spectroscopy?
  Weili Dai,Guangjun Wu,Michael Hunger Chem. Commun., 2015,51, 13779-13782
• 2. Exciplex emission from the mixed dimer of naphthalene and 2-cyanonaphthalene in a supersonic jet
  Aloke Das,K. K. Mahato,Chayan K. Nandi,Tapas Chakraborty,Shridhar R. Gadre,Nikhil A. Gokhale Phys. Chem. Chem. Phys., 2002,4, 2162-2168
• 3. Excellent mechanical performance and enhanced dielectric properties of OBC/SiO2 elastomeric nanocomposites: effect of dispersion of the SiO2 nanoparticles?
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• 4. Exceptional activity of sub-nm Pt clusters on CdS for photocatalytic hydrogen production: a combined experimental and first-principles study?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzofurans Benzofurans
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzofurans

Methyl 2-(6-hydroxy-7-methylbenzofuran-3-yl)acetate (CAS 1380390-17-9): A Comprehensive Overview

Methyl 2-(6-hydroxy-7-methylbenzofuran-3-yl)acetate, with the CAS number 1380390-17-9, is a specialized organic compound that has garnered significant interest in the fields of medicinal chemistry and material science. This compound belongs to the benzofuran family, a class of heterocyclic compounds known for their diverse biological activities and applications in pharmaceuticals and agrochemicals. The presence of both hydroxy and methyl functional groups in its structure makes it a versatile intermediate for further chemical modifications.

The compound's unique structure, featuring a benzofuran core substituted with a hydroxy group at the 6-position and a methyl group at the 7-position, contributes to its potential as a building block for more complex molecules. Researchers are particularly interested in its role as a precursor for synthesizing bioactive compounds, including potential antioxidants and anti-inflammatory agents. The ester functionality in the molecule also offers opportunities for further derivatization, making it a valuable tool in synthetic chemistry.

In recent years, the demand for Methyl 2-(6-hydroxy-7-methylbenzofuran-3-yl)acetate has increased due to its relevance in drug discovery programs. The benzofuran scaffold is widely recognized for its pharmacological properties, and modifications to this core structure can lead to compounds with enhanced bioactivity. For instance, derivatives of this compound have been explored for their potential in treating neurodegenerative diseases, a hot topic in current medical research. The compound's ability to interact with biological targets makes it a promising candidate for further investigation.

From a synthetic perspective, Methyl 2-(6-hydroxy-7-methylbenzofuran-3-yl)acetate can be prepared through various routes, including Pd-catalyzed coupling reactions and cyclization strategies. These methods are often optimized for high yield and purity, ensuring the compound meets the stringent requirements of pharmaceutical applications. The growing interest in green chemistry has also spurred research into more sustainable synthesis pathways for this and related compounds.

The compound's physicochemical properties, such as its solubility, melting point, and stability, are critical for its handling and application. These characteristics are often studied in detail to ensure optimal performance in various experimental settings. For example, its hydroxy group contributes to its solubility in polar solvents, while the methyl group can influence its lipophilicity, an important factor in drug design.

In the context of material science, Methyl 2-(6-hydroxy-7-methylbenzofuran-3-yl)acetate has shown potential as a building block for organic electronic materials. The benzofuran moiety is known for its electron-rich properties, which can be harnessed in the development of organic semiconductors and light-emitting diodes (OLEDs). This application aligns with the current trend toward sustainable and energy-efficient technologies.

The market for Methyl 2-(6-hydroxy-7-methylbenzofuran-3-yl)acetate is expected to grow as its applications expand. Pharmaceutical companies and research institutions are increasingly sourcing high-quality batches of this compound for their projects. Suppliers are responding by improving production processes and ensuring consistent quality, which is essential for reproducibility in scientific studies.

For researchers working with Methyl 2-(6-hydroxy-7-methylbenzofuran-3-yl)acetate, proper storage and handling are crucial. The compound should be kept in a cool, dry place, away from light and moisture, to maintain its stability over time. Safety data sheets (SDS) provide detailed guidelines for its safe use in laboratory settings.

In summary, Methyl 2-(6-hydroxy-7-methylbenzofuran-3-yl)acetate (CAS 1380390-17-9) is a multifaceted compound with significant potential in both pharmaceutical and material science applications. Its unique structural features and versatility make it a valuable asset for researchers exploring new bioactive molecules and advanced materials. As scientific interest in benzofuran derivatives continues to rise, this compound is poised to play an increasingly important role in innovative research and development.

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