• 1. Esterase-responsive polymeric prodrug-based tumor targeting nanoparticles for improved anti-tumor performance against colon cancer?
  Gang Pan,Yi-jie Bao,Jie Xu,Tao Liu,Cheng Liu,Yan-yan Qiu,Xiao-jing Shi,Hui Yu,Ting-ting Jia,Xia Yuan,Ze-ting Yuan,Yi-jun Cao RSC Adv., 2016,6, 42109-42119
• 2. Evolution in surface coverage of CH3NH3PbI3?XClXvia heat assisted solvent vapour treatment and their effects on photovoltaic performance of devices
  Dhirendra K. Chaudhary,Pramendra Kumar,Lokendra Kumar RSC Adv., 2016,6, 94731-94738
• 3. Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals?
  Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203
• 4. Establishing new scaling relations on two-dimensional MXenes for CO2 electroreduction?
  Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
• 5. Fe(iii)-mediated isomerization of α,α-diarylallylic alcohols to ketones via radical 1,2-aryl migration?
  Ziyang Deng,Changwei Chen,Sunliang Cui RSC Adv., 2016,6, 93753-93755

• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Aralkylamines
• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Amines Aralkylamines

Research Brief on 5-(Aminomethyl)thiophen-2-ylmethanamine (CAS: 13752-93-7): Recent Advances and Applications

5-(Aminomethyl)thiophen-2-ylmethanamine (CAS: 13752-93-7) is a bifunctional amine derivative that has garnered significant attention in the field of chemical biology and pharmaceutical research. This compound, characterized by its thiophene backbone and dual amine functionalities, serves as a versatile building block in the synthesis of bioactive molecules, drug candidates, and functional materials. Recent studies have explored its potential in drug discovery, particularly in the development of kinase inhibitors, antimicrobial agents, and targeted therapeutics. This research brief synthesizes the latest findings on this compound, highlighting its synthetic utility, biological activities, and emerging applications.

A 2023 study published in the Journal of Medicinal Chemistry demonstrated the use of 5-(aminomethyl)thiophen-2-ylmethanamine as a key intermediate in the synthesis of novel Bruton's tyrosine kinase (BTK) inhibitors. The researchers utilized its bifunctional nature to construct a series of potent and selective inhibitors, showing promising activity against B-cell malignancies. The study underscored the compound's role in facilitating structure-activity relationship (SAR) optimization, leading to improved pharmacokinetic properties and reduced off-target effects. These findings position 5-(aminomethyl)thiophen-2-ylmethanamine as a valuable scaffold in oncology drug development.

In the realm of antimicrobial research, a recent investigation in Bioorganic & Medicinal Chemistry Letters reported the incorporation of 5-(aminomethyl)thiophen-2-ylmethanamine into novel peptidomimetic compounds targeting bacterial efflux pumps. The study revealed that derivatives of this compound exhibited potent activity against multidrug-resistant Staphylococcus aureus (MRSA) strains, with minimal cytotoxicity against mammalian cells. The researchers attributed this selectivity to the compound's ability to mimic natural peptide substrates while resisting enzymatic degradation. These results highlight its potential in addressing the growing challenge of antibiotic resistance.

Beyond therapeutic applications, 5-(aminomethyl)thiophen-2-ylmethanamine has found utility in materials science. A 2024 publication in ACS Applied Materials & Interfaces described its use as a crosslinking agent in the development of stimuli-responsive hydrogels for drug delivery. The compound's amine groups enabled facile conjugation with polymeric backbones, while its thiophene moiety contributed to the hydrogel's mechanical stability. The resulting materials demonstrated pH-dependent release profiles, making them suitable for targeted delivery of chemotherapeutic agents. This interdisciplinary application underscores the compound's versatility across multiple domains of chemical biology.

From a synthetic chemistry perspective, recent advances have focused on developing more efficient routes to 5-(aminomethyl)thiophen-2-ylmethanamine. A 2023 paper in Organic Process Research & Development presented a scalable, green chemistry approach to its synthesis, utilizing catalytic amination reactions that significantly reduced waste generation compared to traditional methods. The improved synthetic accessibility of this compound is expected to facilitate its broader adoption in both academic and industrial settings, particularly for high-throughput screening and combinatorial chemistry applications.

In conclusion, 5-(aminomethyl)thiophen-2-ylmethanamine (CAS: 13752-93-7) continues to demonstrate significant value across multiple areas of chemical biology and pharmaceutical research. Its unique structural features enable diverse applications ranging from drug discovery to advanced materials development. As research progresses, we anticipate further elucidation of its structure-activity relationships and expansion of its therapeutic potential. Future directions may include exploration of its use in PROTACs (proteolysis targeting chimeras) and other emerging therapeutic modalities, as well as continued optimization of synthetic methodologies for its production.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)