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Comprehensive Overview of (2-Cyano-5-methylphenyl)boronic Acid (CAS No. 1375109-00-4): Properties, Applications, and Industry Insights

(2-Cyano-5-methylphenyl)boronic acid (CAS No. 1375109-00-4) is a specialized boronic acid derivative that has garnered significant attention in pharmaceutical and material science research. This compound, characterized by its cyano (-CN) and methyl (-CH3) functional groups, serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern organic synthesis. Its unique structure enables precise molecular modifications, making it invaluable for developing targeted therapeutics and advanced materials.

In recent years, the demand for boronic acid-based compounds like 1375109-00-4 has surged due to their role in drug discovery, particularly for kinase inhibitors and proteolysis-targeting chimeras (PROTACs). Researchers frequently search for "boronic acid applications in cancer therapy" or "Suzuki coupling reagents 2024," reflecting the compound's relevance in cutting-edge science. The 2-cyano-5-methylphenyl moiety further enhances its utility by improving solubility and binding affinity in biological systems.

From a synthetic chemistry perspective, CAS 1375109-00-4 exhibits exceptional stability under ambient conditions, a critical feature for industrial-scale applications. Analytical techniques such as HPLC and NMR spectroscopy confirm its high purity (>98%), meeting stringent requirements for GMP-compliant production. The compound's molecular weight (175.0 g/mol) and logP value (1.8) make it particularly suitable for medicinal chemistry projects focusing on CNS drug development—a trending topic in pharmaceutical forums.

Environmental considerations have also shaped recent discussions about (2-cyano-5-methylphenyl)boronic acid. With growing interest in "green chemistry alternatives," this compound's low ecotoxicity profile and biodegradability potential position it favorably compared to traditional heavy metal catalysts. Its application in OLED materials and organic semiconductors responds to the booming demand for energy-efficient display technologies—another hot topic in material science circles.

The commercial landscape for 1375109-00-4 reflects these diverse applications. Major suppliers now offer customized bulk quantities with certificates of analysis (CoA), addressing the needs of both academic researchers and industrial manufacturers. Pricing trends show steady demand, particularly from regions with strong biotech infrastructure like North America and Asia-Pacific. For laboratories seeking "high-purity boronic acids" or "reliable cross-coupling partners," this compound represents a strategic investment in future-ready chemistry.

Quality control protocols for (2-cyano-5-methylphenyl)boronic acid have evolved significantly, with advanced LC-MS methods now capable of detecting impurities at ppm levels. This aligns with regulatory emphasis on ICH guidelines for pharmaceutical intermediates. Storage recommendations typically suggest argon-protected environments at 2-8°C to maintain optimal stability—a practical consideration frequently searched by laboratory managers.

Looking ahead, the scientific community anticipates expanded applications of CAS 1375109-00-4 in bioconjugation chemistry and diagnostic probe development. Emerging research explores its potential in fluorescent sensors for biomarker detection, tapping into the growing point-of-care diagnostics market. These developments underscore the compound's versatility beyond traditional synthetic roles, offering researchers multiple avenues for innovation.

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