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Research Brief on Methyl 5-(4-cyanophenyl)Isoxazole-3-carboxylate (CAS: 1375064-54-2): Recent Advances and Applications

Methyl 5-(4-cyanophenyl)isoxazole-3-carboxylate (CAS: 1375064-54-2) is a synthetic compound that has garnered significant attention in the field of chemical biology and medicinal chemistry due to its versatile pharmacological properties. This compound, characterized by its isoxazole core and cyano-substituted phenyl ring, has been explored as a key intermediate in the synthesis of bioactive molecules targeting various diseases. Recent studies have highlighted its potential in drug discovery, particularly in the development of anti-inflammatory, anticancer, and antimicrobial agents. This research brief aims to summarize the latest findings related to this compound, focusing on its synthesis, mechanism of action, and therapeutic applications.

In a recent study published in the Journal of Medicinal Chemistry, researchers investigated the role of Methyl 5-(4-cyanophenyl)isoxazole-3-carboxylate as a precursor in the synthesis of novel kinase inhibitors. The study demonstrated that modifications of the isoxazole ring could enhance binding affinity to specific kinase targets, such as EGFR and VEGFR, which are critical in cancer progression. The compound's ability to act as a scaffold for further functionalization was emphasized, with the cyano group providing a handle for additional chemical modifications. These findings underscore the compound's utility in the design of targeted therapies for oncology.

Another significant advancement was reported in Bioorganic & Medicinal Chemistry Letters, where Methyl 5-(4-cyanophenyl)isoxazole-3-carboxylate was evaluated for its anti-inflammatory properties. The study revealed that the compound exhibited potent inhibitory effects on pro-inflammatory cytokines, such as TNF-α and IL-6, in vitro. Molecular docking studies suggested that the isoxazole moiety interacts with the active site of cyclooxygenase-2 (COX-2), a key enzyme in the inflammatory pathway. These results position the compound as a promising candidate for the development of next-generation anti-inflammatory drugs with improved efficacy and reduced side effects.

Beyond its pharmacological applications, Methyl 5-(4-cyanophenyl)isoxazole-3-carboxylate has also been explored in materials science. A study in ACS Applied Materials & Interfaces highlighted its use as a building block for organic electronic materials. The compound's conjugated system and electron-withdrawing cyano group were found to enhance charge transport properties, making it suitable for applications in organic light-emitting diodes (OLEDs) and photovoltaic devices. This dual utility in both biomedical and materials science underscores the compound's interdisciplinary significance.

In conclusion, Methyl 5-(4-cyanophenyl)isoxazole-3-carboxylate (CAS: 1375064-54-2) continues to be a compound of interest across multiple research domains. Its structural versatility and bioactive potential make it a valuable tool in drug discovery and materials science. Future research should focus on optimizing its pharmacokinetic properties and exploring its applications in emerging therapeutic areas. The integration of computational modeling and high-throughput screening techniques could further accelerate the development of derivatives with enhanced biological activity and selectivity.

• 668970-81-8(3-Isoxazolecarboxylic acid, 5-(2-methylphenyl)-, methyl ester)
• 887360-50-1(5-(4-ethylphenyl)isoxazole-3-carboxylic acid)
• 7063-99-2(Ethyl 5-phenylisoxazole-3-carboxylate)
• 371157-18-5(5-(3,5-Dimethylphenyl)-3-isoxazolecarboxylic acid ethyl ester)
• 893638-47-6(Ethyl 5-(m-tolyl)isoxazole-3-carboxylate)
• 1375064-52-0(4-[3-(Methoxycarbonyl)-5-isoxazolyl]benzoic Acid)
• 88958-15-0(Ethyl 5-(p-tolyl)isoxazole-3-carboxylate)
• 51677-09-9(methyl 5-phenyl-1,2-oxazole-3-carboxylate)
• 1375064-44-0(Methyl 5-(4-Pyridyl)isoxazole-3-carboxylate)
• 33282-10-9(5-(4-Isopropylphenyl)isoxazole-3-carboxylic Acid)