Cas no 1372913-69-3 (2-Naphthalenemethanamine, 1,2,3,4-tetrahydro-α-methyl-, (αS)-)

2-Naphthalenemethanamine, 1,2,3,4-tetrahydro-α-methyl-, (αS)- is a chiral amine derivative of tetralin, characterized by its stereospecific (αS) configuration. This compound serves as a versatile intermediate in organic synthesis, particularly in the preparation of pharmaceuticals and fine chemicals. Its rigid naphthalene backbone and tetrahydro modification enhance stability while the α-methyl group introduces steric control, making it valuable for asymmetric synthesis. The (αS)-enantiomer is often preferred for its predictable reactivity in stereoselective transformations. High purity and well-defined chirality ensure consistent performance in applications such as catalyst design or bioactive molecule development. Suitable for controlled environments, it requires handling under inert conditions to preserve integrity.
2-Naphthalenemethanamine, 1,2,3,4-tetrahydro-α-methyl-, (αS)- structure
1372913-69-3 structure
Product Name:2-Naphthalenemethanamine, 1,2,3,4-tetrahydro-α-methyl-, (αS)-
CAS No:1372913-69-3
MF:C12H17N
MW:175.270083189011
CID:5817378
PubChem ID:65405315
Update Time:2025-10-25

2-Naphthalenemethanamine, 1,2,3,4-tetrahydro-α-methyl-, (αS)- Chemical and Physical Properties

Names and Identifiers

    • 2-Naphthalenemethanamine, 1,2,3,4-tetrahydro-α-methyl-, (αS)-
    • (1s)-1-(1,2,3,4-Tetrahydronaphthalen-2-yl)ethan-1-amine
    • AKOS014741177
    • 1372913-69-3
    • EN300-3088300
    • CS-0266745
    • Inchi: 1S/C12H17N/c1-9(13)11-7-6-10-4-2-3-5-12(10)8-11/h2-5,9,11H,6-8,13H2,1H3/t9-,11?/m0/s1
    • InChI Key: SNGPFEAJYGCEMW-FTNKSUMCSA-N
    • SMILES: [C@H](C1CCC2=CC=CC=C2C1)(N)C

Computed Properties

  • Exact Mass: 175.136099547g/mol
  • Monoisotopic Mass: 175.136099547g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 1
  • Heavy Atom Count: 13
  • Rotatable Bond Count: 1
  • Complexity: 167
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 1
  • Undefined Atom Stereocenter Count : 1
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 2.3
  • Topological Polar Surface Area: 26?2

Experimental Properties

  • Density: 0.998±0.06 g/cm3(Predicted)
  • Boiling Point: 283.0±9.0 °C(Predicted)
  • pka: 10.63±0.29(Predicted)

2-Naphthalenemethanamine, 1,2,3,4-tetrahydro-α-methyl-, (αS)- Pricemore >>

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Additional information on 2-Naphthalenemethanamine, 1,2,3,4-tetrahydro-α-methyl-, (αS)-

Comprehensive Overview of 2-Naphthalenemethanamine, 1,2,3,4-tetrahydro-α-methyl-, (αS)- (CAS No. 1372913-69-3)

The compound 2-Naphthalenemethanamine, 1,2,3,4-tetrahydro-α-methyl-, (αS)- (CAS No. 1372913-69-3) is a chiral amine derivative with a naphthalene backbone, widely recognized for its potential applications in pharmaceutical and organic synthesis. Its unique stereochemistry, denoted by the (αS) configuration, makes it a valuable intermediate in asymmetric synthesis. Researchers and industries are increasingly interested in this compound due to its role in developing enantioselective catalysts and bioactive molecules, aligning with the growing demand for precision in drug design and green chemistry.

In recent years, the scientific community has focused on sustainable synthesis methods and chiral building blocks, both of which are highly relevant to 2-Naphthalenemethanamine, 1,2,3,4-tetrahydro-α-methyl-, (αS)-. Searches for terms like "chiral amine applications" and "naphthalene derivatives in drug discovery" have surged, reflecting its importance in modern research. This compound’s structural features, including the tetrahydro-naphthalene core and methyl-substituted amine, contribute to its versatility in creating high-value intermediates for APIs (Active Pharmaceutical Ingredients).

From a synthetic perspective, CAS No. 1372913-69-3 is often explored for its potential in catalysis and material science. Its stereocenter at the α-position enables selective transformations, a key requirement in industries prioritizing atom economy and waste reduction. Questions like "How to optimize chiral amine synthesis?" or "Role of naphthalene derivatives in OLEDs" frequently appear in academic and industrial forums, underscoring its cross-disciplinary relevance.

Furthermore, the compound’s physicochemical properties, such as solubility and stability, are critical for formulation scientists. Trends in computational chemistry and AI-driven molecular design have also highlighted the need for reliable data on compounds like 2-Naphthalenemethanamine, 1,2,3,4-tetrahydro-α-methyl-, (αS)-. This aligns with the rise of digital lab notebooks and predictive modeling tools, which rely on accurate compound profiles for virtual screening.

In conclusion, 2-Naphthalenemethanamine, 1,2,3,4-tetrahydro-α-methyl-, (αS)- represents a compelling case study in the intersection of chiral chemistry and applied research. Its CAS No. 1372913-69-3 serves as a gateway to innovations in pharmaceuticals, materials, and beyond, addressing both current challenges and future opportunities in science.

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