• 1. Excess electrons in lithium–ethylamine solutions—density, electrical conductivity and EPR studies
  Phys. Chem. Chem. Phys., 1999,1, 3561-3565
• 2. Evolution of dealloying induced strain in nanoporous gold crystals?
  Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693
• 3. Establishing empirical design rules of nucleic acid templates for the synthesis of silver nanoclusters with tunable photoluminescence and functionalities towards targeted bioimaging applications?
  Jason Y. C. Lim,Yong Yu,Guorui Jin,Kai Li,Yi Lu,Jianping Xie Nanoscale Adv., 2020,2, 3921-3932
• 4. Evidence of field induced slow magnetic relaxation in cis-[Co(hfac)2(H2O)2] exhibiting tri-axial anisotropy with a negative axial component?
  Denis V. Korchagin,Elena A. Yureva,Alexander V. Akimov,Eugenii Ya. Misochko,Gennady V. Shilov,Artem D. Talantsev,Roman B. Morgunov,Alexander A. Shakin,Sergey M. Aldoshin,Boris S. Tsukerblat Dalton Trans., 2017,46, 7540-7548
• 5. Emergence of microfluidic wearable technologies
  Joo Chuan Yeo,Kenry Lab Chip, 2016,16, 4082-4090

2,5-Diethynylpyridine: A Comprehensive Overview

2,5-Diethynylpyridine (CAS No. 137000-75-0) is a heterocyclic aromatic compound with significant potential in various chemical and pharmaceutical applications. This compound, characterized by its pyridine ring substituted with two ethynyl groups at the 2 and 5 positions, has garnered attention due to its unique electronic properties and structural versatility. Recent advancements in synthetic methodologies and computational studies have further highlighted its potential in materials science and drug discovery.

The synthesis of 2,5-Diethynylpyridine involves a combination of traditional organic chemistry techniques and modern catalytic processes. Researchers have explored various routes, including the use of transition metal catalysts such as palladium and copper, to achieve efficient and selective formation of this compound. These methods not only enhance the yield but also minimize the environmental footprint, aligning with the growing demand for sustainable chemical synthesis.

One of the most promising applications of 2,5-Diethynylpyridine lies in its use as a building block for advanced materials. Its conjugated system and rigid structure make it an ideal candidate for constructing two-dimensional materials, such as graphene analogs and organic semiconductors. Recent studies have demonstrated that incorporating 2,5-Diethynylpyridine into polymer frameworks can significantly improve their electronic conductivity and mechanical stability, opening new avenues for flexible electronics.

In the pharmaceutical sector, 2,5-Diethynylpyridine has shown potential as a scaffold for developing bioactive molecules. Its ability to form hydrogen bonds and participate in π-π interactions makes it suitable for targeting various biological pathways. For instance, researchers have reported that derivatives of 2,5-Diethynylpyridine exhibit promising anti-inflammatory and anticancer activities in preclinical models. These findings underscore the importance of further exploring its pharmacological properties.

The structural uniqueness of 2,5-Diethynylpyridine also lends itself to applications in supramolecular chemistry. By exploiting its ability to form self-assembled structures through non-covalent interactions, scientists have developed novel materials with tunable properties. For example, studies have shown that 2,5-Diethynylpyridine can form highly ordered supramolecular networks in solution, which could be harnessed for drug delivery systems or sensors.

From a computational standpoint, density functional theory (DFT) studies have provided deeper insights into the electronic structure and reactivity of 2,5-Diethynylpyridine. These studies reveal that the compound exhibits a high degree of aromaticity due to its extended conjugation system. Furthermore, molecular dynamics simulations have shed light on its stability under various environmental conditions, which is crucial for its practical applications.

In conclusion, 2,5-Diethynylpyridine (CAS No. 137000-75-0) stands out as a versatile compound with multifaceted applications across chemistry and materials science. Its unique properties continue to inspire innovative research directions, from sustainable synthesis methods to cutting-edge applications in electronics and medicine. As our understanding of this compound deepens through ongoing studies, it is poised to play an increasingly significant role in advancing modern science.

• 124300-38-5(5-methyl-2-(2-phenylethynyl)pyridine)
• 219480-95-2(Pyridine,2-methyl-5-(1-propyn-1-yl)-)
• 1945-85-3(5-ethynyl-2-methylpyridine)
• 823198-72-7(Pyridine, 5-methyl-2-(phenylethynyl)-, hydrochloride)
• 1945-84-2(2-Ethynylpyridine)
• 30413-61-7(2-ethynyl-5-methylpyridine)
• 512197-95-4(Pyridine, 2-ethynyl-4,5-dimethyl- (9CI))
• 216979-52-1(Pyridine,2,3-diethynyl-)
• 37968-65-3(pyridine, 5-ethyl-2-ethynyl- (9ci))
• 75867-46-8(2,6-Diethynylpyridine)