• 1. Excitation dependent bidirectional electron transfer in phthalocyanine-functionalised MoS2 nanosheets?
  Christopher J. Harrison,Kyle J. Berean,Enrico Della Gaspera,Jian Zhen Ou,Richard B. Kaner,Kourosh Kalantar-zadeh,Torben Daeneke Nanoscale, 2016,8, 16276-16283
• 2. Evolution in surface coverage of CH3NH3PbI3?XClXvia heat assisted solvent vapour treatment and their effects on photovoltaic performance of devices
  Dhirendra K. Chaudhary,Pramendra Kumar,Lokendra Kumar RSC Adv., 2016,6, 94731-94738
• 3. Enantio- & chemo-selective preparation of enantiomerically enriched aliphatic nitro alcohols using Candida parapsilosis ATCC 7330
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• 4. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
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• 5. Excellent humidity sensor based on ultrathin HKUST-1 nanosheets?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Aminopyridines and derivatives

4-Amino-6-bromonicotinonitrile (CAS No. 1369851-48-8): An Overview of Its Properties and Applications in Modern Research

4-Amino-6-bromonicotinonitrile (CAS No. 1369851-48-8) is a versatile organic compound that has garnered significant attention in recent years due to its unique chemical structure and potential applications in various fields, particularly in medicinal chemistry and materials science. This compound, characterized by its amino and bromo substituents on a nicotinonitrile backbone, offers a promising platform for the development of novel pharmaceuticals and advanced materials.

The molecular formula of 4-Amino-6-bromonicotinonitrile is C₇H₅BrN₂, with a molecular weight of approximately 205.03 g/mol. Its structure consists of a pyridine ring with an amino group at the 4-position and a bromine atom at the 6-position, along with a cyano group at the 3-position. This unique arrangement of functional groups imparts distinct chemical properties that make it an attractive candidate for various synthetic transformations and biological studies.

In the realm of medicinal chemistry, 4-Amino-6-bromonicotinonitrile has been explored as a key intermediate in the synthesis of potential therapeutic agents. Recent research has focused on its use as a building block for the development of nicotinamide adenine dinucleotide (NAD+) analogs, which are crucial for cellular metabolism and have shown promise in treating age-related diseases and metabolic disorders. The amino and bromo functionalities provide versatile handles for further functionalization, enabling the synthesis of a wide range of derivatives with tailored biological activities.

Beyond its medicinal applications, 4-Amino-6-bromonicotinonitrile has also found utility in materials science. The presence of the cyano group and the pyridine ring makes it an excellent candidate for the synthesis of conductive polymers and organic semiconductors. These materials are essential components in modern electronic devices, such as organic light-emitting diodes (OLEDs) and organic photovoltaic cells (OPVs). The ability to fine-tune the electronic properties of these materials through controlled synthesis has opened new avenues for their application in next-generation electronic devices.

The synthesis of 4-Amino-6-bromonicotinonitrile typically involves multistep procedures, starting from commercially available precursors. One common approach is to begin with 6-bromonicotinonitrile, which can be converted to the desired compound through selective amino functionalization. Recent advancements in catalytic methods have significantly improved the efficiency and selectivity of these reactions, making large-scale production more feasible.

In terms of safety and handling, 4-Amino-6-bromonicotinonitrile should be stored under dry conditions and protected from light to maintain its stability. It is important to follow standard laboratory safety protocols when handling this compound, including the use of appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coats.

The environmental impact of 4-Amino-6-bromonicotinonitrile is another important consideration. While it is not classified as a hazardous substance under current regulations, responsible disposal practices should be followed to minimize any potential environmental impact. Research into more sustainable synthetic methods that reduce waste and energy consumption is ongoing, aligning with broader efforts to promote green chemistry principles.

In conclusion, 4-Amino-6-bromonicotinonitrile (CAS No. 1369851-48-8) is a multifaceted compound with significant potential in both medicinal chemistry and materials science. Its unique chemical structure provides a robust platform for further research and development, opening new frontiers in drug discovery and advanced materials engineering. As research continues to advance, it is likely that new applications for this compound will emerge, further solidifying its importance in modern scientific endeavors.

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