Cas no 1366482-38-3 (5-(difluoromethyl)-6-fluoropyridin-3-ylboronic acid)
5-(Difluoromethyl)-6-fluoropyridin-3-ylboronic acid is a high-purity boronic acid derivative widely used in Suzuki-Miyaura cross-coupling reactions for the synthesis of complex heterocyclic compounds. Its pyridine core, combined with difluoromethyl and fluorine substituents, enhances reactivity and selectivity in palladium-catalyzed transformations. This compound is particularly valuable in pharmaceutical and agrochemical research, where its structural features contribute to the development of bioactive molecules with improved metabolic stability and binding affinity. The boronic acid group allows for efficient functionalization under mild conditions, making it a versatile intermediate. Strict quality control ensures consistent performance in demanding synthetic applications.
1366482-38-3 structure
Product Name:5-(difluoromethyl)-6-fluoropyridin-3-ylboronic acid
CAS No:1366482-38-3
MF:C6H5BF3NO2
MW:190.915611982346
CID:5607503
PubChem ID:130141826
Update Time:2025-05-27
5-(difluoromethyl)-6-fluoropyridin-3-ylboronic acid Chemical and Physical Properties
Names and Identifiers
-
- Boronic acid, B-[5-(difluoromethyl)-6-fluoro-3-pyridinyl]-
- EN300-8373376
- 1366482-38-3
- [5-(difluoromethyl)-6-fluoropyridin-3-yl]boronic acid
- 5-(difluoromethyl)-6-fluoropyridin-3-ylboronic acid
-
- Inchi： 1S/C6H5BF3NO2/c8-5(9)4-1-3(7(12)13)2-11-6(4)10/h1-2,5,12-13H
- InChI Key： GSRYOQRBGMIZCU-UHFFFAOYSA-N
- SMILES： B(C1=CC(C(F)F)=C(F)N=C1)(O)O
Computed Properties
- Exact Mass: 191.0365431g/mol
- Monoisotopic Mass: 191.0365431g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 2
- Hydrogen Bond Acceptor Count: 6
- Heavy Atom Count: 13
- Rotatable Bond Count: 2
- Complexity: 172
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 53.4?2
Experimental Properties
- Density: 1.44±0.1 g/cm3(Predicted)
- Boiling Point: 339.9±52.0 °C(Predicted)
- pka: 6.22±0.11(Predicted)
5-(difluoromethyl)-6-fluoropyridin-3-ylboronic acid Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Enamine | EN300-8373376-1g |
[5-(difluoromethyl)-6-fluoropyridin-3-yl]boronic acid |
1366482-38-3 | 1g |
$928.0 | 2023-09-02 | ||
| Enamine | EN300-8373376-5g |
[5-(difluoromethyl)-6-fluoropyridin-3-yl]boronic acid |
1366482-38-3 | 5g |
$2692.0 | 2023-09-02 | ||
| Enamine | EN300-8373376-10g |
[5-(difluoromethyl)-6-fluoropyridin-3-yl]boronic acid |
1366482-38-3 | 10g |
$3992.0 | 2023-09-02 | ||
| Enamine | EN300-8373376-0.05g |
[5-(difluoromethyl)-6-fluoropyridin-3-yl]boronic acid |
1366482-38-3 | 95% | 0.05g |
$780.0 | 2024-05-21 | |
| Enamine | EN300-8373376-0.1g |
[5-(difluoromethyl)-6-fluoropyridin-3-yl]boronic acid |
1366482-38-3 | 95% | 0.1g |
$817.0 | 2024-05-21 | |
| Enamine | EN300-8373376-0.25g |
[5-(difluoromethyl)-6-fluoropyridin-3-yl]boronic acid |
1366482-38-3 | 95% | 0.25g |
$855.0 | 2024-05-21 | |
| Enamine | EN300-8373376-0.5g |
[5-(difluoromethyl)-6-fluoropyridin-3-yl]boronic acid |
1366482-38-3 | 95% | 0.5g |
$891.0 | 2024-05-21 | |
| Enamine | EN300-8373376-1.0g |
[5-(difluoromethyl)-6-fluoropyridin-3-yl]boronic acid |
1366482-38-3 | 95% | 1.0g |
$928.0 | 2024-05-21 | |
| Enamine | EN300-8373376-2.5g |
[5-(difluoromethyl)-6-fluoropyridin-3-yl]boronic acid |
1366482-38-3 | 95% | 2.5g |
$1819.0 | 2024-05-21 | |
| Enamine | EN300-8373376-5.0g |
[5-(difluoromethyl)-6-fluoropyridin-3-yl]boronic acid |
1366482-38-3 | 95% | 5.0g |
$2692.0 | 2024-05-21 |
5-(difluoromethyl)-6-fluoropyridin-3-ylboronic acid Related Literature
-
Peiyuan Zeng,Xiaoxiao Wang,Ming Ye,Qiuyang Ma,Jianwen Li,Wanwan Wang,Baoyou Geng,Zhen Fang RSC Adv., 2016,6, 23074-23084
-
Min Kim,Jae-Joon Lee,Tengling Ye,Panagiotis E. Keivanidis,Kilwon Cho J. Mater. Chem. C, 2020,8, 1686-1696
-
J. Matthew Kurley,Phillip W. Halstenberg,Abbey McAlister,Stephen Raiman,Richard T. Mayes RSC Adv., 2019,9, 25602-25608
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Manickam Bakthadoss,Tadiparthi Thirupathi Reddy,Vishal Agarwal,Duddu S. Sharada Chem. Commun., 2022,58, 1406-1409
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Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
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