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• 2. Fe3O4@PANI: a magnetic polyaniline nanomaterial for highly efficient and handy enrichment of intact N-glycopeptides??
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• 3. Estimation of activation energy for electroporation and pore growth rate in liquid crystalline and gel phases of lipid bilayers using molecular dynamics simulations?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Thiophenes Thiophene carboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Thiophenes Thiophene carboxylic acids and derivatives Thiophene carboxylic acids

3-Acetylthiophene-2-carboxylic acid (CAS No. 13657-90-4): A Comprehensive Overview

3-Acetylthiophene-2-carboxylic acid, also known by its CAS registry number CAS No. 13657-90-4, is a compound of significant interest in the fields of organic chemistry, pharmacology, and materials science. This compound belongs to the class of thiophenes, which are five-membered heterocyclic aromatic compounds containing one sulfur atom. The presence of an acetyl group at the 3-position and a carboxylic acid group at the 2-position imparts unique chemical properties to this molecule, making it a valuable substrate for various applications.

The structure of 3-Acetylthiophene-2-carboxylic acid consists of a thiophene ring with two substituents: an acetyl group (-COCH?) at the 3-position and a carboxylic acid group (-COOH) at the 2-position. This arrangement creates a molecule with both electron-withdrawing and electron-donating groups, which can influence its reactivity and electronic properties. The thiophene ring itself is aromatic, contributing to the stability and reactivity of the compound.

Recent studies have highlighted the potential of 3-Acetylthiophene-2-carboxylic acid in drug discovery and development. Its unique structure allows for interactions with various biological targets, including enzymes and receptors. For instance, researchers have explored its ability to modulate enzyme activity, making it a promising candidate for therapeutic interventions in diseases such as cancer and neurodegenerative disorders.

In terms of synthesis, 3-Acetylthiophene-2-carboxylic acid can be prepared through several routes, including oxidation of thioethers or via coupling reactions involving thiophene derivatives. The choice of synthetic method depends on the starting materials and desired purity. Recent advancements in catalytic methods have improved the efficiency and selectivity of these reactions, enabling large-scale production for industrial applications.

The physical properties of 3-Acetylthiophene-2-carboxylic acid include a melting point of approximately 180°C and a boiling point around 400°C under standard conditions. Its solubility in common solvents such as water, ethanol, and dichloromethane has been well-documented, facilitating its use in various chemical reactions and analytical techniques.

The application of 3-Acetylthiophene-2-carboxylic acid extends beyond pharmaceuticals. It has been investigated as a precursor for advanced materials, including conductive polymers and organic semiconductors. Its ability to form stable complexes with metal ions makes it a potential candidate for catalytic applications as well.

In conclusion, 3-Acetylthiophene-2-carboxylic acid (CAS No. 13657-90-4) is a versatile compound with a wide range of applications in chemistry and related disciplines. Ongoing research continues to uncover new insights into its properties and potential uses, solidifying its position as an important molecule in modern science.

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