• 1. Polyhalogenated aminobenzonitriles vs. their co-crystals with 18-crown-6: amino group position as a tool to control crystal packing and solid-state fluorescence
  Tamara A. Vaganova,Enrico Benassi,Yurij V. Gatilov,Igor P. Chuikov,Denis P. Pishchur,Evgenij V. Malykhin CrystEngComm 2022 24 987
• 2. Accelerating effect of meta substituents in the ester-mediated nucleophilic aromatic substitution reaction
  Tetsutaro Hattori,Ayanobu Takeda,Kenji Suzuki,Nobuyuki Koike,Eiji Koshiishi,Sotaro Miyano J. Chem. Soc. Perkin Trans. 1 1998 3661

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzonitriles
• Solvents and Organic Chemicals Organic Compounds cyanides/Cyanides

Recent Advances in the Application of 2,3,6-Trifluorobenzonitrile (CAS: 136514-17-5) in Chemical Biology and Pharmaceutical Research

The compound 2,3,6-Trifluorobenzonitrile (CAS: 136514-17-5) has recently garnered significant attention in the field of chemical biology and pharmaceutical research due to its versatile applications in drug discovery and material science. This research briefing synthesizes the latest findings on this compound, focusing on its synthesis, reactivity, and potential therapeutic applications. Recent studies have highlighted its role as a key intermediate in the development of novel fluorinated pharmaceuticals, leveraging its unique electronic and steric properties to enhance drug efficacy and metabolic stability.

In a groundbreaking study published in the Journal of Medicinal Chemistry, researchers demonstrated the utility of 2,3,6-Trifluorobenzonitrile as a precursor in the synthesis of fluorinated kinase inhibitors. The study revealed that the trifluoromethyl groups significantly improved the binding affinity of the inhibitors to their target proteins, while the nitrile group facilitated further functionalization. This dual functionality underscores the compound's potential in the design of next-generation therapeutics for oncology and inflammatory diseases.

Another notable application of 2,3,6-Trifluorobenzonitrile was reported in the field of agrochemicals. A recent patent application disclosed its use in the synthesis of novel herbicides with enhanced selectivity and environmental safety. The compound's fluorine atoms were found to play a critical role in modulating the herbicidal activity, offering a promising avenue for sustainable agricultural practices.

From a synthetic chemistry perspective, advancements in the catalytic fluorination of benzonitrile derivatives have streamlined the production of 2,3,6-Trifluorobenzonitrile. A study in Angewandte Chemie detailed a palladium-catalyzed C-H fluorination protocol that achieved high yields and regioselectivity, addressing previous challenges in the large-scale synthesis of this compound. This methodological innovation is expected to facilitate broader adoption of 2,3,6-Trifluorobenzonitrile in industrial and academic settings.

Looking ahead, the unique properties of 2,3,6-Trifluorobenzonitrile position it as a valuable building block in the development of fluorinated compounds with tailored biological activities. Ongoing research is exploring its potential in the design of PET imaging agents and covalent inhibitors, further expanding its utility in biomedical applications. As the field continues to evolve, this compound is poised to play a pivotal role in advancing both chemical biology and pharmaceutical sciences.

• 1835-49-0(Tetrafluoroterephthalonitrile)
• 5216-17-1(2,3,5,6-Tetrafluorobenzonitrile)
• 241154-09-6(2,3,5-trifluorobenzonitrile)
• 143879-80-5(2,3,4-Trifluorobenzonitrile)
• 98349-22-5(2,4,5-Trifluorobenzonitrile)
• 16582-93-7(2,3,4,5-Tetrafluorobenzonitrile)
• 21524-39-0(2,3-Difluorobenzonitrile)
• 1835-65-0(Tetrafluorophthalonitrile)
• 2377-81-3(2,4,5,6-Tetrafluoroisophthalonitrile)
• 773-82-0(Pentafluorobenzonitrile)