Cas no 1361923-09-2 (4-Cyano-3-methyl-2-(trifluoromethoxy)pyridine)
4-Cyano-3-methyl-2-(trifluoromethoxy)pyridine is a versatile pyridine derivative featuring a cyano group at the 4-position, a methyl group at the 3-position, and a trifluoromethoxy substituent at the 2-position. This compound exhibits high chemical stability due to the electron-withdrawing effects of the cyano and trifluoromethoxy groups, making it suitable for use in demanding synthetic applications. The trifluoromethoxy moiety enhances lipophilicity, which can improve bioavailability in pharmaceutical contexts. Its structural features make it a valuable intermediate in the synthesis of agrochemicals, pharmaceuticals, and specialty materials. The presence of multiple functional groups allows for further derivatization, enabling the development of complex molecular architectures. This compound is particularly useful in cross-coupling reactions and as a building block for heterocyclic chemistry.
1361923-09-2 structure
Product Name:4-Cyano-3-methyl-2-(trifluoromethoxy)pyridine
CAS No:1361923-09-2
MF:C8H5F3N2O
MW:202.133311986923
CID:4910168
Update Time:2025-07-02
4-Cyano-3-methyl-2-(trifluoromethoxy)pyridine Chemical and Physical Properties
Names and Identifiers
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- 4-Cyano-3-methyl-2-(trifluoromethoxy)pyridine
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- Inchi: 1S/C8H5F3N2O/c1-5-6(4-12)2-3-13-7(5)14-8(9,10)11/h2-3H,1H3
- InChI Key: PGJQNQWNENGRJW-UHFFFAOYSA-N
- SMILES: FC(OC1C(C)=C(C#N)C=CN=1)(F)F
Computed Properties
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 6
- Heavy Atom Count: 14
- Rotatable Bond Count: 1
- Complexity: 245
- XLogP3: 2.5
- Topological Polar Surface Area: 45.9
4-Cyano-3-methyl-2-(trifluoromethoxy)pyridine Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Alichem | A026004757-250mg |
4-Cyano-3-methyl-2-(trifluoromethoxy)pyridine |
1361923-09-2 | 97% | 250mg |
$734.40 | 2022-04-02 | |
| Alichem | A026004757-500mg |
4-Cyano-3-methyl-2-(trifluoromethoxy)pyridine |
1361923-09-2 | 97% | 500mg |
$1,029.00 | 2022-04-02 | |
| Alichem | A026004757-1g |
4-Cyano-3-methyl-2-(trifluoromethoxy)pyridine |
1361923-09-2 | 97% | 1g |
$1,797.60 | 2022-04-02 |
4-Cyano-3-methyl-2-(trifluoromethoxy)pyridine Related Literature
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Inês S. Albuquerque,Hélia F. Jeremias,Miguel Chaves-Ferreira,Dijana Matak-Vinkovic,Omar Boutureira,Carlos C. Rom?o Chem. Commun., 2015,51, 3993-3996
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Li-Hua Gan,Rui Wu,Jian-Lei Tian,Patrick W. Fowler Phys. Chem. Chem. Phys., 2017,19, 419-425
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Huabin Zhang,Shaowu Du CrystEngComm, 2014,16, 4059-4068
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Yaqing Liu,Jiangtao Ren,Jing Li,Jiyang Liu,Erkang Wang Chem. Commun., 2012,48, 802-804
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Lei Yang,Yuan Zeng,Haibo Wu,Chunwu Zhou,Lei Tao J. Mater. Chem. B, 2020,8, 1383-1388
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