Cas no 13614-98-7 (Minocycline hydrochloride)

Minocycline hydrochloride is a semisynthetic tetracycline antibiotic derived from minocycline, exhibiting broad-spectrum activity against Gram-positive and Gram-negative bacteria. Its enhanced lipid solubility allows for superior tissue penetration and prolonged half-life compared to earlier tetracyclines. The hydrochloride salt form improves solubility in aqueous solutions, facilitating formulation versatility. Minocycline hydrochloride is particularly effective against atypical pathogens, including Chlamydia and Mycoplasma species, as well as certain anaerobic bacteria. Its bacteriostatic action is achieved through inhibition of protein synthesis by binding to the 30S ribosomal subunit. The compound is widely utilized in treating acne, respiratory infections, and other systemic bacterial infections, with demonstrated stability under standard storage conditions.
Minocycline hydrochloride structure
Minocycline hydrochloride structure
Product Name:Minocycline hydrochloride
CAS No:13614-98-7
MF:C23H28ClN3O7
MW:493.9373254776
MDL:MFCD00083669
CID:49370
PubChem ID:24278175
Update Time:2025-11-06

Minocycline hydrochloride Chemical and Physical Properties

Names and Identifiers

    • (4S,4aS,5aR,12aS)-4,7-Bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride
    • Minocycline HCL
    • Minocyclin HCl
    • (4s-(4alpha,4aalpha,5aalpha,12aalpha))-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxonaphthacene-2-carboxamide monohydrochloride
    • Minocycline hydrochloride
    • minocyclinehydrochloridehydrate
    • Minocycline
    • Minocycline (hydrochloride)
    • Minocycline Hydrochl
    • Minocyline hydrochloride
    • [4S-(4alpha,4aalpha,5aalpha,12aalpha)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxonaphthacene-2-carboxamide monohydrochloride
    • minocyn
    • MINOCIN
    • Arestin
    • Dynacin
    • tri-mino
    • MYNOCINE
    • Klinomyci
    • Minomycin
    • Periofeel
    • Klinomycin
    • Minocycline chloride
    • Vectrin
    • Periocline
    • Minomax
    • Solodyn
    • Mynocine hydrochloride
    • Tri-minocycline
    • Minocycline, Hydrochloride
    • Minocycline hydrochloride (internal use)
    • 0020414E5U
    • MINO
    • DSSTox_RID_80306
    • DSSTox_CID_24545
    • DSSTox_GSID_44545
    • Minocyclinehydrochloride
    • minomycin hydrochloride
    • CCG-40107
    • NCGC00255988-01
    • M2288
    • (4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamidehydrochloride
    • 7-Dimethylamino-6-demethyl-6-deoxytetracycline, HCl
    • ZILXI
    • Tox21_301590
    • 2-Naphthacenecarboxamide, 4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, hydrochloride (1:2), (4S,4aS,5aR,12aS)-
    • Acnez
    • Prestwick_626
    • MLS002548863
    • Minocycline (as hydrochloride)
    • BCP06597
    • Q-201407
    • [4S-(4a,4aa,5aa,12aa)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a,tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide
    • CS-1256
    • Q27104777
    • NC00460
    • HY-17412
    • NSC757120
    • SMR001906766
    • EINECS 237-099-7
    • MINOCYCLINE HYDROCHLORIDE [MART.]
    • PD003090
    • MINOCYCLINE HYDROCHLORIDE [USP MONOGRAPH]
    • HB4617
    • s4226
    • CAS-13614-98-7
    • Minocycline hydrochloride, crystalline
    • Ximino
    • Minomycin chloride
    • NSC-141993
    • CHEBI:50697
    • HMS1568P12
    • Minocycline hydrochloride, United States Pharmacopeia (USP) Reference Standard
    • C23H27N3O7.HCl
    • Pharmakon1600-01500414
    • UNII-0020414E5U
    • Arestin (TN)
    • SCHEMBL2537
    • NCGC00096006-01
    • DTXCID6024545
    • Dynacin (TN)
    • Minocycline hydrochloride, European Pharmacopoeia (EP) Reference Standard
    • Minocycline Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material
    • MINOCYCLINE HYDROCHLORIDE [JAN]
    • 10118-90-8 (base)
    • MINOCYCLINE HYDROCHLORIDE [MI]
    • AKOS015951312
    • Minocycline hydrochloride (JP17/USP)
    • SPECTRUM1500414
    • NSC-757120
    • Minocin (TN)
    • AC-22362
    • AS-75306
    • CHEMBL4576719
    • Tox21_111250_1
    • Lederderm
    • Solodyn (TN)
    • Tox21_111250
    • 13614-98-7
    • 4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride
    • MINOCYCLINE HYDROCHLORIDE [VANDF]
    • FXFM-244
    • NCGC00178854-03
    • (4S,12aS,4aS,5aR)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-4,5,6,12a,4a,5a-hexahydronaphthacene-2-carboxamide Hydrochloride
    • Tox21_113183
    • 2-Naphthacenecarboxamide, 4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, monohydrochloride, (4S-(4alpha,4aalpha,5aalpha,12aalpha))-
    • CHEMBL1200881
    • MFCD00083669
    • 2-NAPHTHACENECARBOXAMIDE, 4,7-BIS(DIMETHYLAMINO)-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-, MONOHYDROCHLORIDE, (4S-(4.ALPHA.,4A.ALPHA.,5A.ALPHA.,12A.ALPHA.))-
    • MINOCYCLINE HYDROCHLORIDE [ORANGE BOOK]
    • GLMUAFMGXXHGLU-VQAITOIOSA-N
    • NS00076430
    • MINOCYCLINE HYDROCHLORIDE [WHO-DD]
    • 2-Naphthacenecarboxamide, 4,7- bis(dimethylamino)-1,4,4a,5,5a,6,11,12a- octahydro-3,10,12,12a-tetrahydroxy-1,11dioxo-, monohydrochloride, [4S-(4alpha,4aalpha,5aalpha,12aalpha)]
    • (4S,4aS,5aR,12aR)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;hydrochloride
    • [4S-(4?,4a?,5a?,12a?)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a,tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide
    • [4S-(4alpha,4aalpha,5aalpha,12aalpha)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a,tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide
    • Minocycline hydrochloride, Antibiotic for Culture Media Use Only
    • SR-01000075625
    • SR-01000075625-1
    • Minocyclinhydrochlorid
    • DTXSID8044545
    • AMZEEQ
    • D00850
    • [4S-(4alpha,4aalpha,5aalpha,12aalpha)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxonaphthacene-2-carboxamide monohydrochloride;[4S-(4alpha,4aalpha,5aalpha,12aalpha)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxonaphthacene-2-carboxamide monohydrochloride
    • Minocycline hydrochloride [USP:JAN]
    • MINOLIRA
    • MINOCYCLINE HYDROCHLORIDE [USP-RS]
    • NSC 141993
    • 7-Dimethylamino-6-demethyl-6-deoxytetracycline
    • (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE
    • (4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-1,10,12,12a-tetrahydroxy-3,11-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide hydrochloride
    • SBI-0051449.0002
    • DA-75552
    • Minocycline hydrochloride (JP18/USP)
    • MDL： MFCD00083669
    • Inchi： 1S/C23H27N3O7.ClH/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28;/h5-6,9,11,17,27-28,31,33H,7-8H2,1-4H3,(H2,24,32);1H/t9-,11-,17-,23-;/m0./s1
    • InChI Key： WTJXVDPDEQKTCV-VQAITOIOSA-N
    • SMILES： Cl.O[C@@]12C(=C(C(N)=O)C([C@H]([C@@H]1C[C@@H]1CC3C(=CC=C(C=3C(=C1C2=O)O)O)N(C)C)N(C)C)=O)O

Computed Properties

  • Exact Mass: 493.16200
  • Monoisotopic Mass: 493.162
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 6
  • Hydrogen Bond Acceptor Count: 9
  • Heavy Atom Count: 34
  • Rotatable Bond Count: 3
  • Complexity: 971
  • Covalently-Bonded Unit Count: 2
  • Defined Atom Stereocenter Count: 4
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 165
  • Surface Charge: 0
  • Tautomer Count: 288
  • XLogP3: nothing

Experimental Properties

  • Color/Form: Tigecycline hydrochloride
  • Density: 1.0170
  • Melting Point: 213-218°C
  • Boiling Point: 813℃
  • Flash Point: >110°(230°F)
  • Solubility: Freely soluble in water
  • Water Partition Coefficient: Freely soluble in water
  • Stability/Shelf Life: Light Sensitive
  • PSA: 164.63000
  • LogP: 1.68890
  • Merck: 6202
  • Specific Rotation: -170 ~ -180° (c=0.5, 0.1ml/L HCl)
  • Sensitiveness: Sensitive to heat
  • Solubility: Soluble in water
  • Vapor Pressure: No data available

Minocycline hydrochloride Security Information

  • Symbol: GHS07
  • Prompt：dangerous
  • Signal Word：Warning
  • Hazard Statement： H315,H319,H335
  • Warning Statement： P261,P305+P351+P338
  • Hazardous Material transportation number：3249
  • WGK Germany：3
  • Hazard Category Code： 36/37/38
  • Safety Instruction： S26-S36
  • Regulatory Condition Code：Class Q (sugars, alkaloids, antibiotics, hormones)
  • RTECS：QI7630500
  • Hazardous Material Identification： Xi
  • Packing Group：III
  • Hazard Level：6.1(b)
  • HazardClass：6.1(b)
  • PackingGroup：III
  • Storage Condition：2-8°C
  • Safety Term：6.1(b)
  • Packing Group：III
  • Risk Phrases：R36/37/38

Minocycline hydrochloride Customs Data

  • HS CODE：2942000000
  • Customs Data：

    China Customs Code:

    2942000000

Minocycline hydrochloride Pricemore >>

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(CAS:13614-98-7)Minocycline hydrochloride
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Minocycline hydrochloride Spectrogram

1H NMR 300 MHz DMSO
1H NMR
13C NMR
13C NMR

Minocycline hydrochloride Related Literature

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Additional information on Minocycline hydrochloride

Minocycline Hydrochloride (CAS No. 13614-98-7): A Comprehensive Overview

Minocycline hydrochloride, with the chemical compound identifier CAS No. 13614-98-7, is a semi-synthetic derivative of the tetracycline class of antibiotics. This compound has garnered significant attention in the field of pharmaceutical chemistry due to its broad-spectrum antimicrobial properties and diverse therapeutic applications. The hydrochloride salt form enhances its solubility and bioavailability, making it particularly effective in various medical formulations.

The mechanism of action of Minocycline hydrochloride involves the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. This binding prevents the proper assembly of aminoacyl-tRNA onto the ribosome, thereby halting bacterial growth and replication. Its efficacy against a wide range of Gram-positive and Gram-negative bacteria, as well as certain atypical pathogens, has made it a cornerstone in the treatment of various infections.

Recent advancements in microbiology and pharmacology have highlighted the potential of Minocycline hydrochloride beyond its traditional applications. Studies have demonstrated its role in modulating inflammatory responses, making it a promising candidate for treating chronic inflammatory diseases such as rheumatoid arthritis and psoriasis. The compound's ability to inhibit matrix metalloproteinases (MMPs) has been particularly noted, which contributes to its anti-inflammatory effects.

In addition to its antimicrobial and anti-inflammatory properties, Minocycline hydrochloride has shown promise in neurodegenerative disease research. Preliminary studies suggest that it may help mitigate neuroinflammation and oxidative stress, which are key pathological features in conditions like Alzheimer's disease and Parkinson's disease. The compound's ability to cross the blood-brain barrier further enhances its potential as a therapeutic agent in central nervous system disorders.

The pharmacokinetic profile of Minocycline hydrochloride is characterized by high bioavailability and prolonged half-life, allowing for less frequent dosing. This makes it particularly convenient for patients requiring long-term treatment. The compound is well-tolerated in most cases, though side effects such as gastrointestinal discomfort and discoloration of teeth have been reported. These side effects are generally mild and manageable with appropriate dosing adjustments.

The synthesis and purification of Minocycline hydrochloride adhere to stringent pharmaceutical standards to ensure safety and efficacy. Advanced synthetic methodologies have been developed to optimize yield and purity, reducing impurities that could potentially affect therapeutic outcomes. These advancements contribute to the overall quality and reliability of Minocycline hydrochloride as a pharmaceutical product.

The clinical applications of Minocycline hydrochloride extend beyond infectious diseases. Its anti-inflammatory properties have led to its investigation in treating acne vulgaris, where it has shown efficacy comparable to other tetracycline derivatives but with a lower incidence of resistance. Furthermore, its potential role in managing periodontal diseases has been explored due to its ability to reduce bacterial load and inflammation in periodontal tissues.

Ongoing research continues to uncover new therapeutic possibilities for Minocycline hydrochloride. Its interactions with various biological pathways suggest potential applications in oncology, where it may help modulate tumor microenvironment dynamics. Additionally, studies are exploring its use in wound healing, leveraging its anti-inflammatory and tissue-repair promoting properties.

The regulatory landscape for Minocycline hydrochloride is shaped by rigorous testing and approval processes to ensure patient safety and therapeutic efficacy. Regulatory agencies require comprehensive data on its pharmacological effects, safety profiles, and manufacturing processes before approving it for clinical use. This ensures that patients receive high-quality medications that meet stringent standards.

In conclusion, Minocycline hydrochloride (CAS No. 13614-98-7) remains a vital component in modern medicine due to its broad-spectrum antimicrobial activity, anti-inflammatory effects, and potential applications in treating various conditions beyond traditional infections. The ongoing research into its mechanisms of action and therapeutic applications continues to expand its utility in both acute and chronic disease management.

13614-98-7 (Minocycline hydrochloride) Related Products

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Suzhou Senfeida Chemical Co., Ltd
(CAS:13614-98-7)Minocycline hydrochloride
sfd14774
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Quantity:200kg
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Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:13614-98-7)Minocycline hydrochloride
LE10612;LE26125637
Purity:99%/99%
Quantity:25KG,200KG,1000KG/25KG,200KG,1000KG
Price ($):Inquiry/Inquiry
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