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  Chem. Commun., 1998, 1501-1502
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Methylpyridines

Comprehensive Overview of (5-Fluoro-3-methylpyridin-2-yl)methanol (CAS No. 1360953-18-9): Properties, Applications, and Industry Insights

(5-Fluoro-3-methylpyridin-2-yl)methanol (CAS No. 1360953-18-9) is a fluorinated pyridine derivative that has garnered significant attention in pharmaceutical and agrochemical research due to its unique structural features. This compound, characterized by a fluoro-substituted pyridine ring and a hydroxymethyl functional group, serves as a versatile intermediate in synthetic chemistry. Its molecular formula, C₇H₈FNO, and precise steric configuration make it valuable for designing bioactive molecules targeting enzymes and receptors.

Recent trends in drug discovery highlight the growing demand for fluorinated building blocks like (5-Fluoro-3-methylpyridin-2-yl)methanol. Fluorination enhances metabolic stability and bioavailability, addressing key challenges in CNS drug development—a topic frequently searched in AI-driven literature reviews. Researchers also explore its role in crop protection chemicals, aligning with sustainable agriculture trends. The compound’s hydrogen-bonding capacity and lipophilic balance are often discussed in Q&A forums, reflecting industry interest in structure-activity relationships (SAR).

From a synthetic perspective, CAS 1360953-18-9 is typically prepared via selective fluorination of 3-methylpyridine precursors, followed by hydroxymethylation. Advanced purification techniques like preparative HPLC ensure high purity (>98%), critical for regulatory submissions—a recurring concern in pharmaceutical manufacturing queries. Analytical data (NMR, LC-MS) confirm its identity, while stability studies under varying pH conditions are frequently cited in patent applications.

The compound’s safety profile is rigorously documented. While not classified as hazardous, proper handling guidelines for fluorinated organics are emphasized in SDS sheets, matching workplace safety searches. Its environmental persistence data, particularly biodegradation rates, respond to eco-conscious formulation trends. Computational modeling studies predict low aquatic toxicity, making it a candidate for green chemistry initiatives—a hot topic in 2024’s AI-driven research proposals.

Market analysts note rising procurement of 1360953-18-9 by CROs for kinase inhibitor projects. This correlates with increased searches for custom fluorinated intermediates and small-batch API synthesis. The compound’s cost-efficiency compared to analogous bromo-derivatives is another key discussion point in procurement forums. Suppliers increasingly highlight its availability in GMP-grade quantities, addressing quality concerns in preclinical development phases.

Innovative applications include its use in PET tracer development, leveraging the fluorine-18 isotope. This aligns with diagnostic imaging market growth—a trending search among radiopharmaceutical professionals. Recent publications also describe its incorporation into metal-organic frameworks (MOFs) for catalytic applications, tapping into nanomaterials research queries. Such multidisciplinary utility underscores why (5-Fluoro-3-methylpyridin-2-yl)methanol remains a high-demand chemical entity in 2024.

Regulatory landscapes influence its usage patterns. The compound’s compliance with REACH and FDA ICH guidelines is extensively documented, responding to compliance-related searches. Stability data across climatic zones (ICH Q1A) make it suitable for global supply chains—a priority for pharma logistics teams. These factors position CAS 1360953-18-9 as a future-proof intermediate in regulated industries.

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