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  Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
• 2. Evolutionary de novo design of phenothiazine derivatives for dye-sensitized solar cells?
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Professional Introduction to 4,5-Dibromo-1H-benzimidazole (CAS No. 1360922-53-7)

4,5-Dibromo-1H-benzimidazole, identified by the Chemical Abstracts Service Number (CAS No.) 1360922-53-7, is a significant heterocyclic compound that has garnered considerable attention in the field of pharmaceutical and medicinal chemistry. This compound belongs to the benzimidazole family, a class of molecules known for their diverse biological activities and utility in drug development. The presence of bromine substituents at the 4 and 5 positions enhances its reactivity and makes it a valuable intermediate in synthetic chemistry.

The benzimidazole core is a privileged scaffold in medicinal chemistry, exhibiting a wide range of pharmacological properties. It has been extensively studied for its roles in modulating various biological pathways, including enzyme inhibition, receptor binding, and DNA intercalation. The introduction of bromine atoms into the benzimidazole ring introduces electrophilic centers that can participate in nucleophilic substitution reactions, making 4,5-Dibromo-1H-benzimidazole a versatile building block for the synthesis of more complex molecules.

In recent years, 4,5-Dibromo-1H-benzimidazole has been explored in the development of novel therapeutic agents. Its structural features make it an attractive candidate for designing compounds with enhanced binding affinity and selectivity. For instance, studies have demonstrated its potential in targeting specific enzymes and receptors involved in inflammatory diseases, cancer, and infectious disorders. The brominated benzimidazole derivatives derived from this compound have shown promising preclinical activity in models of these conditions.

One of the most compelling aspects of 4,5-Dibromo-1H-benzimidazole is its role as a precursor in the synthesis of biologically active molecules. Researchers have leveraged its reactive sites to develop libraries of compounds for high-throughput screening (HTS) campaigns. These efforts have led to the identification of several lead compounds with therapeutic potential. The ability to functionalize the bromine atoms allows for further derivatization, enabling chemists to fine-tune the properties of the resulting compounds.

Recent advancements in computational chemistry have also highlighted the importance of 4,5-Dibromo-1H-benzimidazole in drug discovery. Molecular modeling studies suggest that modifications at the 4 and 5 positions can significantly influence binding interactions with biological targets. This has guided the design of more potent and selective analogs, further underscoring the compound's significance in medicinal chemistry.

The synthesis of 4,5-Dibromo-1H-benzimidazole typically involves bromination reactions on a parent benzimidazole scaffold. While traditional bromination methods are well-established, recent innovations have focused on improving yield and selectivity through catalytic approaches. These methods not only enhance efficiency but also reduce waste, aligning with green chemistry principles.

In addition to its pharmaceutical applications, 4,5-Dibromo-1H-benzimidazole has found utility in materials science. Its ability to form stable complexes with metal ions has been exploited in designing luminescent materials and sensors. These applications leverage the unique electronic properties of brominated benzimidazoles, demonstrating their versatility beyond traditional medicinal chemistry contexts.

The future prospects for 4,5-Dibromo-1H-benzimidazole are promising, with ongoing research focusing on expanding its applications. Novel synthetic strategies are being developed to access derivatives with tailored properties, while computational methods continue to refine our understanding of its interactions with biological targets. As drug discovery efforts evolve, compounds like 4,5-Dibromo-1H-benzimidazole will remain integral to the development of next-generation therapeutics.

Overall,4,5-Dibromo-1H-benzimidazole (CAS No. 1360922-53-7) stands as a cornerstone in synthetic and medicinal chemistry due to its structural versatility and biological relevance. Its continued exploration promises to yield innovative solutions across multiple scientific disciplines.

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