• 1. Synthesis of indole derivatives as prevalent moieties present in selected alkaloids
  Majid M. Heravi,Zahra Amiri,Kosar Kafshdarzadeh,Vahideh Zadsirjan RSC Adv. 2021 11 33540
• 2. LXXXVIII.—The influence of nitro-groups on the reactivity of substituents in the benzene nucleus. Part IX. 2 : 3- and 2 : 5-Dinitro-4-methoxytoluenes
  Herbert Eric Dadswell,James Kenner J. Chem. Soc. 1927 580
• 3. Reactions of quinones with aromatic ethers. Part IV. Dibenzofurans from the cyclisation of arylbenzoquinones
  Oliver C. Musgrave,Colin J. Webster J. Chem. Soc. Perkin Trans. 1 1974 2263
• 4. High-performance organic photorefractive materials containing 2-ethylhexyl plasticized poly(triarylamine)
  Kuo-Lung Wang,Jia-Cheng Jiang,Cang-He Jhu,Satoshi Wada,Takafumi Sassa,Masaki Horie J. Mater. Chem. C 2020 8 13357
• 5. 1 : 2 : 3 : 4-Tetrahydro-6-hydroxy-7-methylcarbazole and 3-hydroxy-2-methylcarbazole
  José A. Cummins,B. F. Kaye,Muriel L. Tomlinson J. Chem. Soc. 1954 1414

• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers Aminophenyl ethers
• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides

4-Methoxy-3-methylaniline (CAS No. 136-90-3): An Overview of Its Properties, Applications, and Recent Research

4-Methoxy-3-methylaniline (CAS No. 136-90-3) is a versatile organic compound that has garnered significant attention in the fields of chemistry, pharmaceuticals, and materials science. This compound, also known as 2-Amino-5-methoxytoluene or 2-Amino-4-methoxytoluene, is characterized by its unique molecular structure, which includes a methoxy and a methyl group attached to an aniline backbone. The combination of these functional groups imparts specific chemical properties that make 4-Methoxy-3-methylaniline a valuable intermediate in various synthetic processes.

The molecular formula of 4-Methoxy-3-methylaniline is C₉H₁₂N₂O, and its molecular weight is approximately 168.19 g/mol. The compound is a colorless to light yellow liquid at room temperature and has a distinct aromatic odor. It is soluble in organic solvents such as ethanol, acetone, and dichloromethane but has limited solubility in water. These physical properties make it suitable for use in various chemical reactions and industrial processes.

In the pharmaceutical industry, 4-Methoxy-3-methylaniline serves as an important intermediate in the synthesis of several drugs and pharmaceutical compounds. Its reactivity and functional group versatility allow it to be used in the preparation of intermediates for drugs that target specific biological pathways. For example, recent research has explored its potential in the development of new antifungal agents and anti-inflammatory drugs. The methoxy group enhances the lipophilicity of the molecule, which can improve its bioavailability and cellular uptake.

In materials science, 4-Methoxy-3-methylaniline has been investigated for its use in the synthesis of advanced materials such as polymers and dyes. Its ability to participate in various chemical reactions makes it a valuable building block for creating materials with tailored properties. For instance, it can be used to synthesize polymeric materials with enhanced thermal stability and mechanical strength. Additionally, its aromatic structure makes it suitable for use in the production of dyes and pigments with improved colorfastness and stability.

Recent studies have also focused on the environmental impact of 4-Methoxy-3-methylaniline and its derivatives. Researchers are exploring methods to synthesize this compound using more sustainable and environmentally friendly processes. Green chemistry principles are being applied to reduce the use of hazardous reagents and minimize waste generation during synthesis. This approach not only aligns with global sustainability goals but also enhances the economic viability of producing 4-Methoxy-3-methylaniline on a larger scale.

The safety profile of 4-Methoxy-3-methylaniline is another critical aspect that has been extensively studied. While it is generally considered safe when handled properly, appropriate safety measures should be taken to prevent exposure to skin or inhalation of vapors. Safety data sheets (SDS) provide detailed information on handling, storage, and disposal procedures to ensure safe use in laboratory and industrial settings.

In conclusion, 4-Methoxy-3-methylaniline (CAS No. 136-90-3) is a multifaceted compound with a wide range of applications in chemistry, pharmaceuticals, and materials science. Its unique chemical properties make it an essential intermediate in various synthetic processes, contributing to the development of new drugs, advanced materials, and sustainable chemical practices. Ongoing research continues to uncover new potential uses for this compound, further solidifying its importance in modern scientific endeavors.

• 90257-69-5(Benzenamine, 4-ethoxy-3,5-dimethyl-)
• 39785-37-0(4-Methoxy-3,5-dimethylaniline)
• 56705-83-0(4-(2-methylphenoxy)aniline)
• 83054-57-3(Benzenamine, 4-[(4-methoxy-1-naphthalenyl)oxy]-3-methyl-)
• 38608-08-1(4-Methoxy-5-methylbenzene-1,2-diamine)
• 1185297-84-0(4-Methoxy-3-methylaniline hydrochloride)
• 16452-01-0(3-Methoxy-4-methylaniline)
• 137791-98-1(Hexaneperoxoic acid,2-ethyl-, tert-hexyl ester)
• 83054-45-9(Benzenamine, 3-methyl-4-(1-naphthalenyloxy)-)
• 41280-55-1(4-(2,6-Dimethylphenoxy)aniline)