• 1. An investigation on the interaction modes of a single-strand DNA aptamer and RBP4 protein: a molecular dynamic simulations approach?
  Raheleh Torabi,Hedayatollah Ghourchian,Massoud Amanlou Org. Biomol. Chem., 2016,14, 8141-8153
• 2. An analyte-triggered artificial peroxidase system based on dimanganese complex for a versatile enzyme assay?
  Suji Lee,Min Su Han Chem. Commun., 2021,57, 9450-9453
• 3. Acetyl group orientation modulates the electronic ground-state asymmetry of the special pair in purple bacterial reaction centers
  P. K. Wawrzyniak,M. T. P. Beerepoot,H. J. M. de Groot,F. Buda Phys. Chem. Chem. Phys., 2011,13, 10270-10279
• 4. An artificial photosynthetic system for photoaccumulation of two electrons on a fused dipyridophenazine (dppz)–pyridoquinolinone ligand?
  Philipp Traber,Stephan Kupfer,Stefanie Gr?fe,Isabelle Baussanne,Martine Demeunynck,Jean-Marie Mouesca,Serge Gambarelli,Vincent Artero,Murielle Chavarot-Kerlidou Chem. Sci., 2018,9, 4152-4159
• 5. An anti-leakage liquid metal thermal interface material
  Kaiyuan Huang,Wangkang Qiu,Meilian Ou,Xiaorui Liu,Zenan Liao,Sheng Chu RSC Adv., 2020,10, 18824-18829

Introduction to 2-(Ethoxycarbonyl)-1,3-thiazole-5-carboxylic Acid (CAS No. 1357247-55-2)

2-(Ethoxycarbonyl)-1,3-thiazole-5-carboxylic acid (CAS No. 1357247-55-2) is a versatile organic compound that has garnered significant attention in the fields of medicinal chemistry and pharmaceutical research. This compound belongs to the class of thiazoles, which are known for their diverse biological activities and potential therapeutic applications. The unique structural features of 2-(ethoxycarbonyl)-1,3-thiazole-5-carboxylic acid make it an attractive candidate for various chemical and biological studies.

The molecular formula of 2-(ethoxycarbonyl)-1,3-thiazole-5-carboxylic acid is C₉H₉N₁O₄S, and its molecular weight is 231.24 g/mol. The compound is characterized by a thiazole ring system substituted with an ethoxycarbonyl group at the 2-position and a carboxylic acid group at the 5-position. These functional groups contribute to its chemical reactivity and biological properties.

In recent years, thiazoles have been extensively studied for their potential as scaffolds in drug discovery. The presence of the ethoxycarbonyl and carboxylic acid groups in 2-(ethoxycarbonyl)-1,3-thiazole-5-carboxylic acid provides multiple points of functionalization, making it a valuable intermediate in the synthesis of more complex molecules. This compound has been utilized in the development of novel drugs targeting various diseases, including cancer, inflammation, and neurological disorders.

The synthetic route to 2-(ethoxycarbonyl)-1,3-thiazole-5-carboxylic acid typically involves multi-step processes that include the formation of the thiazole ring and subsequent functional group modifications. One common approach involves the reaction of an appropriate thioamide with a haloacetic acid derivative, followed by esterification to introduce the ethoxycarbonyl group. The final step often involves hydrolysis to convert the ester to the carboxylic acid form.

2-(Ethoxycarbonyl)-1,3-thiazole-5-carboxylic acid has been shown to exhibit promising biological activities in various assays. For instance, studies have demonstrated its potential as an inhibitor of specific enzymes involved in metabolic pathways. This property makes it a candidate for further investigation in the context of metabolic disorders and related conditions.

In addition to its enzymatic inhibition properties, 2-(ethoxycarbonyl)-1,3-thiazole-5-carboxylic acid has also been explored for its anti-inflammatory effects. In vitro studies have shown that this compound can reduce the production of pro-inflammatory cytokines and chemokines, suggesting its potential as a therapeutic agent for inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.

The pharmacokinetic properties of 2-(ethoxycarbonyl)-1,3-thiazole-5-carboxylic acid have also been evaluated in preclinical studies. These studies have provided insights into its absorption, distribution, metabolism, and excretion (ADME) profiles. The compound has been found to exhibit favorable pharmacokinetic properties, including good oral bioavailability and a reasonable half-life, which are important considerations for drug development.

Clinical trials involving derivatives of 2-(ethoxycarbonyl)-1,3-thiazole-5-carboxylic acid are currently underway to assess their safety and efficacy in human subjects. Early results from these trials have shown promising outcomes, with some compounds demonstrating significant therapeutic benefits with minimal side effects.

The structural versatility of 2-(ethoxycarbonyl)-1,3-thiazole-5-carboxylic acid has also led to its use as a building block in combinatorial chemistry approaches. By modifying different functional groups on the molecule, researchers can generate libraries of compounds with diverse chemical structures and biological activities. This approach has accelerated the discovery of novel therapeutics with improved potency and selectivity.

In conclusion, 2-(ethoxycarbonyl)-1,3-thiazole-5-carboxylic acid (CAS No. 1357247-55-2) is a promising compound with a wide range of potential applications in medicinal chemistry and pharmaceutical research. Its unique structural features and favorable biological properties make it an attractive candidate for further investigation and development as a therapeutic agent. Ongoing research continues to uncover new insights into its mechanisms of action and potential clinical applications.

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