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  Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693
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  Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
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  Qiaoe Wang,Meiling Lian,Xiaowen Zhu,Xu Chen RSC Adv., 2021,11, 192-197
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• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Aralkylamines
• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Amines Aralkylamines

Comprehensive Overview of 3-(Piperidin-1-yl)methylpyridine (CAS No. 13552-35-7): Properties, Applications, and Industry Insights

3-(Piperidin-1-yl)methylpyridine (CAS No. 13552-35-7) is a specialized organic compound that has garnered significant attention in pharmaceutical and chemical research due to its unique structural features. This heterocyclic molecule combines a pyridine ring with a piperidine moiety, making it a versatile intermediate for synthesizing bioactive molecules. Its molecular formula, C₁₁H₁₆N₂, and molecular weight of 176.26 g/mol underscore its relevance in medicinal chemistry and material science.

The compound's chemical structure features a methylpyridine core linked to a piperidine group, which enhances its solubility in polar organic solvents. Researchers frequently explore its potential as a building block for drug discovery, particularly in designing CNS-targeting agents and enzyme inhibitors. Recent studies highlight its role in optimizing ligand-receptor interactions, aligning with the growing demand for precision therapeutics in oncology and neurology.

In industrial applications, 3-(Piperidin-1-yl)methylpyridine serves as a precursor for catalysts and functional materials. Its stability under moderate temperatures (melting point: ~80-85°C) makes it suitable for high-performance polymer synthesis. Manufacturers emphasize its low environmental persistence, addressing modern concerns about green chemistry and sustainable synthesis—a trending topic in 2024 as industries adopt EPA-compliant processes.

Analytical characterization of CAS No. 13552-35-7 typically involves HPLC, GC-MS, and NMR spectroscopy. The compound's UV-Vis absorption profile (λ_max ~260 nm) facilitates quality control during production. Regulatory databases classify it as non-hazardous under standard handling conditions, though proper PPE (e.g., nitrile gloves) is recommended during lab-scale operations.

Emerging research explores its derivatization for bioimaging probes, capitalizing on the pyridine ring's fluorescence properties. This aligns with the booming diagnostics market, where users frequently search for "fluorescent markers for cell imaging." Patent literature reveals innovative uses in OLED materials, responding to the global push for energy-efficient displays.

Supply chain data indicates growing demand from contract research organizations (CROs) and academic labs, particularly in North America and APAC regions. Storage recommendations include amber vials at 2-8°C under inert atmosphere to prevent oxidative degradation—a critical consideration for buyers searching "long-term storage of nitrogen heterocycles."

From a commercial perspective, 3-(Piperidin-1-yl)methylpyridine is available in >98% purity from major chemical suppliers, with custom synthesis options for isotope-labeled variants (e.g., ¹³C or ¹⁵N). Pricing trends reflect its niche status, with bulk purchases (>1 kg) offering 20-30% cost reductions—a key detail for procurement teams optimizing R&D budgets.

The compound's structure-activity relationship (SAR) continues to inspire computational chemistry studies. Molecular docking simulations suggest potential affinity for G-protein-coupled receptors (GPCRs), a hot topic in AI-driven drug design forums. Such applications resonate with researchers investigating "machine learning for lead compound optimization"—a frequently Googled phrase in 2024.

Environmental fate studies demonstrate ready biodegradability (>60% in 28 days per OECD 301B), positioning it favorably against persistent halogenated compounds. This eco-profile supports its inclusion in green chemistry toolkits, addressing ESG (Environmental, Social, and Governance) criteria now prioritized by pharmaceutical investors.

In summary, 3-(Piperidin-1-yl)methylpyridine (CAS No. 13552-35-7) represents a multifaceted compound bridging medicinal chemistry and advanced materials. Its evolving applications—from neuropharmacology to optoelectronics—make it a compelling subject for researchers navigating the intersection of small molecule innovation and industrial sustainability.

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