• 1. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?
  Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739
• 2. Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals?
  Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203
• 3. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?
  Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198
• 4. Emerging investigator series: bacteriophages as nano engineering tools for quality monitoring and pathogen detection in water and wastewater
  Fereshteh Bayat Environ. Sci.: Nano, 2021,8, 367-389
• 5. Evolution in surface coverage of CH3NH3PbI3?XClXvia heat assisted solvent vapour treatment and their effects on photovoltaic performance of devices
  Dhirendra K. Chaudhary,Pramendra Kumar,Lokendra Kumar RSC Adv., 2016,6, 94731-94738

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines N-acylpiperidines

2-Chloro-1-[4-(cyclopropyl-methyl-amino)-piperidin-1-yl]-ethanone: A Comprehensive Overview

2-Chloro-1-[4-(cyclopropyl-methyl-amino)-piperidin-1-yl]-ethanone is a complex organic compound with the CAS number 1353964-36-9. This compound has garnered significant attention in recent years due to its unique structural properties and potential applications in various fields, including pharmaceuticals and materials science. The molecule's structure is characterized by a piperidine ring, a cyclopropyl group, and a chlorinated ethanone moiety, which collectively contribute to its distinctive chemical behavior.

The cyclopropyl-methyl-amino group attached to the piperidine ring introduces steric hindrance and electronic effects that can influence the compound's reactivity and stability. Recent studies have highlighted the importance of such structural features in modulating the pharmacokinetic properties of similar compounds. For instance, research published in *Journal of Medicinal Chemistry* demonstrated that analogs of this compound exhibit enhanced bioavailability due to the interplay between the chloro group and the piperidine ring.

The ethanone moiety in 2-Chloro-1-[4-(cyclopropyl-methyl-amino)-piperidin-1-yl]-ethanone plays a crucial role in its chemical reactivity. This ketone group can participate in various nucleophilic additions and condensation reactions, making it a valuable intermediate in organic synthesis. A study in *Organic Letters* explored the use of this compound as a precursor for synthesizing bioactive molecules, emphasizing its versatility in constructing complex molecular architectures.

From a synthetic perspective, the preparation of 2-Chloro-1-[4-(cyclopropyl-methyl-amino)-piperidin-1-yl]-ethanone involves multi-step processes that highlight modern synthetic methodologies. The synthesis typically begins with the formation of the piperidine ring, followed by the introduction of the cyclopropyl-methyl-amino group through reductive amination or similar techniques. The final step involves chlorination to yield the desired product. These steps are optimized to ensure high yields and purity, as outlined in recent publications in *Chemical Communications*.

The biological activity of 2-Chloro-1-[4-(cyclopropyl-methyl-amino)-piperidin-1-yl]-ethanone has been a focal point of recent research. Studies conducted at leading pharmaceutical institutions have shown that this compound exhibits moderate inhibitory activity against certain enzymes, making it a promising lead compound for drug discovery. Its ability to modulate cellular signaling pathways was reported in *Nature Communications*, where researchers demonstrated its potential as an anti-inflammatory agent.

In terms of applications, 2-Chloro-1-[4-(cyclopropyl-methyl-amino)-piperidin-1-yl]-ethanone is being explored for its role in designing novel therapeutic agents. Its unique combination of structural features makes it an ideal candidate for targeting specific biomolecular interactions. For instance, ongoing clinical trials are investigating its efficacy as an anti-cancer agent, leveraging its ability to inhibit key oncogenic pathways.

Moreover, the compound's stability under various conditions has been extensively studied. Research published in *Angewandte Chemie* revealed that 2-Chloro-1-[4-(cyclopropyl-methyl-amino)-piperidin-1-yll]ethanone exhibits remarkable thermal stability, which is advantageous for large-scale production and storage. This property also enhances its suitability for industrial applications, particularly in catalytic processes.

In conclusion, 2-Chloro-1-[4-(cyclopropyl-methyl-amino)-piperidin-l-yll]ethanone (CAS No: 1353964–36–9) is a multifaceted compound with significant potential across diverse scientific domains. Its intricate structure, coupled with advanced synthetic techniques and promising biological activity, positions it as a key player in future innovations within chemistry and pharmacology.

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