• 1. Excitation energies from ground-state density-functionals by means of generator coordinates
  A. B. F. da Silva,K. Capelle Phys. Chem. Chem. Phys., 2009,11, 4564-4569
• 2. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?
  Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739
• 3. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
• 4. Evidence for the intrinsic nature of band-gap states electrochemically observed on atomically flat TiO2(110) surfaces?
  Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789
• 5. Fast synthesis of copper nanoclusters through the use of hydrogen peroxide additive and their application for the fluorescence detection of Hg2+ in water samples?
  Liao Xiaoqing,Li Ruiyi,Li Zaijun,Sun Xiulan,Wang Zhouping,Liu Junkang New J. Chem., 2015,39, 5240-5248

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ketones
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Carbonyl compounds Ketones

Professional Introduction to Compound with CAS No. 1352210-81-1 and Product Name: 2-Chloro-1-(4-chloro-3-methylphenyl)-2,2-difluoroethanone

The compound with the CAS number 1352210-81-1 and the product name 2-Chloro-1-(4-chloro-3-methylphenyl)-2,2-difluoroethanone represents a significant advancement in the field of organic chemistry and pharmaceutical research. This compound, characterized by its unique structural features, has garnered considerable attention due to its potential applications in drug development and synthetic chemistry. The presence of multiple halogen atoms and a highly functionalized aromatic ring system makes it a versatile intermediate for various chemical transformations.

In recent years, the pharmaceutical industry has witnessed a surge in the demand for novel heterocyclic compounds that exhibit enhanced biological activity. The structure of 2-Chloro-1-(4-chloro-3-methylphenyl)-2,2-difluoroethanone aligns well with this trend, as it incorporates both chloro and fluoro substituents, which are known to improve metabolic stability and binding affinity to biological targets. This compound’s potential as a building block in medicinal chemistry has been explored in several cutting-edge research studies.

One of the most compelling aspects of this compound is its role as a precursor in the synthesis of biologically active molecules. Researchers have leveraged its reactive sites to develop novel scaffolds for kinase inhibitors, which are crucial in treating various forms of cancer and inflammatory diseases. The 4-chloro-3-methylphenyl moiety, in particular, has been identified as a key pharmacophore in several drug candidates, contributing to their efficacy and selectivity. This underscores the importance of 2-Chloro-1-(4-chloro-3-methylphenyl)-2,2-difluoroethanone as a valuable asset in pharmaceutical libraries.

Moreover, the difluoroethanone group within the molecule introduces unique electronic properties that can modulate the reactivity and stability of the compound. Such features are highly sought after in medicinal chemistry, as they can enhance drug-like properties such as solubility, bioavailability, and metabolic resistance. Recent studies have demonstrated that derivatives of this compound exhibit promising activities against bacterial infections and viral pathogens, highlighting its therapeutic potential.

The synthesis of 2-Chloro-1-(4-chloro-3-methylphenyl)-2,2-difluoroethanone involves a series of well-defined chemical steps that showcase the ingenuity of modern synthetic methodologies. The use of palladium-catalyzed cross-coupling reactions has enabled researchers to construct the complex aromatic system with high precision. Additionally, the introduction of fluorine atoms has been achieved through electrophilic aromatic substitution reactions, which are both efficient and scalable.

In terms of applications beyond pharmaceuticals, this compound has shown promise in materials science. Its ability to participate in polymerization reactions makes it a candidate for developing advanced materials with tailored properties. For instance, researchers have explored its use in creating flame-retardant polymers by incorporating it into the backbone structure. This dual functionality—pharmaceutical relevance and material science utility—makes 1352210-81-1 a compound of broad interest.

The latest advancements in computational chemistry have further enhanced our understanding of this molecule’s behavior. Molecular modeling studies have revealed insights into how different substituents influence its electronic structure and reactivity. These insights are being used to guide the design of next-generation derivatives with improved properties. For example, virtual screening techniques have identified new analogs that may exhibit higher binding affinities to target proteins.

The environmental impact of synthesizing and using this compound is also a critical consideration. Efforts have been made to develop greener synthetic routes that minimize waste and reduce energy consumption. Catalytic processes, for instance, have been optimized to improve yields while maintaining high selectivity. Such sustainable practices are essential for ensuring that the production of valuable compounds like 1352210-81-1 remains environmentally responsible.

Looking ahead, the future prospects for 2-Chloro-1-(4-chloro-3-methylphenyl)-2,2-difluoroethanone appear bright. Ongoing research is focused on expanding its applications into new therapeutic areas and developing innovative synthetic strategies. Collaborative efforts between academia and industry are expected to drive further breakthroughs, leveraging the compound’s unique structural features for next-generation drug discovery.

• 1352222-18-4(1-(3-chloro-4-methylphenyl)-2,2-difluoroethan-1-one)
• 1352232-00-8(1-(4-chloro-3-methylphenyl)-2,2-difluoroethan-1-one)
• 774-29-8(2-chloro-1-(4-chlorophenyl)-2,2-difluoroethanone)
• 1823319-80-7(1-(4-Chloro-3,5-dimethylphenyl)-2,2-difluoroethanone)
• 1352222-04-8(2-Chloro-1-(3-chloro-2-methylphenyl)-2,2-difluoroethanone)
• 141110-96-5(Ethanone, 2-chloro-2,2-difluoro-1-(2-naphthalenyl)-)
• 384-67-8(2-chloro-2,2-difluoro-1-phenylethan-1-one)
• 408529-06-6( )
• 164342-68-1(1,3-Butanedione, 4-chloro-1-(4-chlorophenyl)-4,4-difluoro-)
• 89264-09-5(Ethanone,2-chloro-2,2-difluoro-1-(4-methylphenyl)-)