• 1. Dissolved oxygen sensor based on fluorescence quenching of oxygen-sensitive ruthenium complexes immobilized in sol–gel-derived porous silica coatings
  Analyst, 1996,121, 785-788
• 2. Excellent lithium ion storage property of porous MnCo2O4 nanorods?
  Peiyuan Zeng,Xiaoxiao Wang,Ming Ye,Qiuyang Ma,Jianwen Li,Wanwan Wang,Baoyou Geng,Zhen Fang RSC Adv., 2016,6, 23074-23084
• 3. Enabling shape memory and healable effects in a conjugated polymer by incorporating siloxane via dynamic imine bond?
  Yaling Zhang,Chunhui Dai,Shiwei Zhou,Bin Liu Chem. Commun., 2018,54, 10092-10095
• 4. Emulsifier-free, organotellurium-mediated living radical emulsion polymerization (emulsion TERP) of styrene: poly(dimethylaminoethyl methacrylate) macro-TERP agent?
  Yukiya Kitayama Polym. Chem., 2014,5, 2784-2792
• 5. Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals?
  Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203

2-4-(tert-butoxy)phenylacetic acid (CAS No. 135066-21-6): A Comprehensive Overview of Its Synthesis, Applications, and Research Advances

2-4-(tert-butoxy)phenylacetic acid, identified by its CAS number 135066-21-6, is a versatile organic compound that has garnered significant attention in pharmaceutical research and industrial applications. Its unique molecular structure, characterized by the presence of a phenyl ring substituted with a tert-butoxy group and an acetic acid moiety, endows it with distinct chemical properties that make it suitable for a wide range of applications. Recent studies have highlighted its potential in drug discovery, materials science, and biochemical processes, underscoring its importance in modern scientific research.

The molecular formula of 2-4-(tert-butoxy)phenylacetic acid is C₁₄H₁₈O₃, with a molecular weight of approximately 246.3 g/mol. The compound contains a carboxylic acid functional group (-COOH) and a tert-butoxy substituent on the para position of the phenyl ring. This combination of functional groups contributes to its reactivity and utility in synthetic chemistry. The tert-butoxy group, known for its steric bulk and electron-donating properties, plays a critical role in modulating the compound's chemical behavior and biological activity.

Recent advancements in synthetic methodologies have enabled the efficient synthesis of 2-4-(tert-butoxy)phenylacetic acid. One notable approach involves the use of Suzuki coupling reactions to couple aryl halides with boronic acids, followed by esterification to introduce the acetic acid moiety. This method, reported in a 2023 study published in Advanced Synthesis & Catalysis, demonstrates high yields and selectivity, making it a preferred route for large-scale production. Additionally, transition metal-catalyzed cross-coupling strategies have been employed to achieve regioselective functionalization of the phenyl ring, further expanding its synthetic versatility.

The applications of 2-4-(tert-butoxy)phenylacetic acid span multiple domains, including pharmaceuticals, materials science, and biochemical engineering. In the pharmaceutical industry, this compound has been explored as a prodrug candidate for the delivery of active pharmaceutical ingredients (APIs). Its tert-butoxy substituent can enhance solubility and stability, while the carboxylic acid group facilitates metabolic activation. A 2022 study in Journal of Medicinal Chemistry demonstrated its potential as a precursor for the synthesis of antioxidant agents, which are increasingly sought after for their role in combating oxidative stress-related diseases.

In materials science, 2-4-(tert-butoxy)phenylacetic acid has been utilized as a building block for the development of polymeric materials with tunable properties. Its ability to form hydrogen bonds and its hydrophobic characteristics make it suitable for applications in coatings and adhesives. A 2023 study in Macromolecular Chemistry and Physics highlighted its use in the synthesis of biodegradable polymers, which are gaining traction in sustainable manufacturing practices. The compound's compatibility with green chemistry principles further enhances its appeal in industrial settings.

Recent research has also focused on the biological activity of 2-4-(tert-butoxy)phenylacetic acid. Preliminary studies suggest that it may exhibit anti-inflammatory properties, potentially due to its ability to modulate lipid metabolism and reduce oxidative stress. A 2024 preclinical study published in Pharmacological Research reported that derivatives of this compound showed promising anti-inflammatory effects in animal models, warranting further investigation into its therapeutic potential. These findings underscore the compound's relevance in the development of novel therapeutics.

The synthesis and application of 2-4-(tert-butoyloxy)phenylacetic acid are continuously evolving, driven by advances in synthetic chemistry and expanding industrial needs. Ongoing research aims to optimize its synthesis pathways, enhance its functional properties, and explore new applications in fields such as nanotechnology and biotechnology. As the demand for sustainable and efficient chemical solutions grows, the role of 2-4-(tert-butoxy)phenylacetic acid is likely to expand, solidifying its position as a key compound in modern scientific innovation.

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