• 1. Enzymatic hydrolysis of l-azetidine-2-carboxylate ring opening
  Xuexia Xu,Qin Yang,Lanteng Wang,Jie Zheng,Yang Gu,Xiwen Xing,Jiahai Zhou Catal. Sci. Technol. 2023 13 3953
• 2. Enantioselective syntheses of (S)- and (R)-3-hydroxypyrrolidin-2-ones via lactate dehydrogenase catalysed reductions of 4-benzyloxycarbonylamino-2-oxobutanoic acid
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• 3. Enantioselective syntheses of (S)- and (R)-3-hydroxypyrrolidin-2-ones via lactate dehydrogenase catalysed reductions of 4-benzyloxycarbonylamino-2-oxobutanoic acid
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• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives

Comprehensive Overview of 2-Hydroxy-4-amino Butanoic Acid (CAS No. 13477-53-7): Properties, Applications, and Industry Insights

2-Hydroxy-4-amino Butanoic Acid (CAS No. 13477-53-7), also known as 4-Amino-2-hydroxybutyric acid, is a multifunctional organic compound with significant relevance in biochemical and industrial applications. This amino acid derivative features both hydroxyl and amino functional groups, making it a versatile building block in peptide synthesis, nutraceutical formulations, and cosmetic ingredients. Its unique structure enables interactions with biological systems, sparking interest in sustainable biomaterials and green chemistry innovations.

Recent trends highlight growing demand for bio-based chemicals, with 2-Hydroxy-4-amino Butanoic Acid gaining attention as a potential natural alternative to synthetic additives. Researchers are exploring its role in skin barrier enhancement, aligning with the booming clean beauty movement. Studies suggest its moisturizing properties could rival hyaluronic acid, a frequently searched term in cosmetic science. Additionally, its compatibility with vegan formulations addresses the rising consumer preference for plant-derived ingredients.

From a technical perspective, the compound's chirality (optical activity) is critical for pharmaceutical applications. The L-isomer of 2-Hydroxy-4-amino Butanoic Acid shows higher bioavailability, a key consideration for nutraceutical efficacy. Analytical techniques like HPLC purity testing and mass spectrometry characterization are essential for quality control, topics frequently queried in scientific databases. The compound's water solubility and pH stability also make it suitable for liquid supplement formulations, a rapidly growing market segment.

Industrial production methods for CAS 13477-53-7 have evolved to meet GMP compliance standards. Modern enzymatic synthesis routes reduce environmental impact compared to traditional chemical processes, resonating with ESG (Environmental, Social, and Governance) priorities in chemical manufacturing. Supply chain data indicates increased adoption in Asia-Pacific markets, particularly for hair care actives and wound healing formulations.

Emerging research explores 2-Hydroxy-4-amino Butanoic Acid's potential in metabolic pathways modulation. Preliminary findings suggest it may influence collagen biosynthesis, connecting to popular searches about anti-aging compounds. However, comprehensive clinical trials are needed to validate these observations. The compound's metal-chelating capacity also positions it as a candidate for antioxidant synergists in functional foods.

Regulatory status varies by region, with INCI naming approvals facilitating cosmetic use. Safety assessments confirm low skin irritation potential, an important factor for sensitive skin formulations. Technical specifications typically require ≥98% purity, with residual solvent limits adhering to ICH guidelines – a frequent search topic among quality assurance professionals.

Storage recommendations for 13477-53-7 emphasize moisture-controlled environments due to its hygroscopic nature. Proper handling maintains the compound's crystalline structure, ensuring consistent performance in end applications. Thermal stability studies indicate decomposition above 200°C, relevant for high-temperature processing scenarios.

The future outlook for 2-Hydroxy-4-amino Butanoic Acid appears promising, with patent analysis revealing increased activity in biodegradable polymer applications. Its compatibility with 3D bioprinting matrices aligns with advancements in tissue engineering, another trending research area. As sustainable chemistry gains momentum, this compound's carbon-neutral production potential may drive further adoption across industries.

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