• 1. An all-solid-state asymmetric device based on a polyaniline hydrogel for a high energy flexible supercapacitor?
  Hamid Heydari,Mohammad B. Gholivand New J. Chem., 2017,41, 237-244
• 2. Alt-proteins: A promising future
• 3. An autonomous self-optimizing flow machine for the synthesis of pyridine–oxazoline (PyOX) ligands?
  Eric Wimmer,Daniel Cortés-Borda,Solène Brochard,Elvina Barré,Charlotte Truchet,Fran?ois-Xavier Felpin React. Chem. Eng., 2019,4, 1608-1615
• 4. An amorphous carbon nitride/NiO/CoN-based composite: a highly efficient nonprecious electrode for supercapacitors and the oxygen evolution reaction?
  Huifang Yang,Haoran Guo,Peidong Fan,Xinpan Li,Wenlu Ren,Rui Song Nanoscale, 2020,12, 7024-7034
• 5. An integrated chip for immunofluorescence and its application to analyze lysosomal storage disorders
  Jie Shen,Ying Zhou,Tu Lu,Junya Peng,Zhixiang Lin,Yuhong Pang,Li Yu Lab Chip, 2012,12, 317-324

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Pyrazole carboxylic acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Pyrazoles Pyrazole carboxylic acids and derivatives

3-Chloro-1H-pyrazole-4-carboxylic Acid (CAS 134589-59-6): Properties, Applications, and Market Insights

3-Chloro-1H-pyrazole-4-carboxylic acid (CAS 134589-59-6) is a versatile heterocyclic compound that has garnered significant attention in pharmaceutical and agrochemical research. This pyrazole derivative serves as a crucial building block for synthesizing various bioactive molecules, making it a valuable intermediate in modern chemical industries.

The molecular structure of 3-chloro-1H-pyrazole-4-carboxylic acid features a five-membered aromatic ring containing two nitrogen atoms, with a chlorine substituent at the 3-position and a carboxylic acid group at the 4-position. This unique arrangement contributes to its reactivity and makes it an excellent precursor for drug discovery applications. Researchers particularly value its potential in developing kinase inhibitors, which are currently a hot topic in cancer treatment research.

In pharmaceutical applications, 3-Chloro-1H-pyrazole-4-carboxylic acid CAS 134589-59-6 has shown promise in the synthesis of various therapeutic agents. Its structural motif appears in several FDA-approved drugs, particularly those targeting inflammatory diseases and metabolic disorders. The compound's ability to form stable complexes with metal ions also makes it interesting for medicinal chemistry applications, especially in the design of novel metallodrugs.

The agrochemical industry utilizes 3-chloro pyrazole carboxylic acid derivatives in developing new-generation pesticides and herbicides. Its structural features contribute to the bioactivity of these compounds, offering solutions for crop protection against resistant pests - a growing concern in modern agriculture. Recent studies have explored its derivatives as potential plant growth regulators, addressing the increasing demand for sustainable agricultural practices.

From a synthetic chemistry perspective, 134589-59-6 serves as a valuable intermediate for various organic transformations. Its carboxylic acid group allows for easy derivatization through esterification or amidation reactions, while the chloro substituent enables further functionalization via cross-coupling reactions. These properties make it particularly useful in combinatorial chemistry and high-throughput screening approaches.

The global market for 3-Chloro-1H-pyrazole-4-carboxylic acid has shown steady growth, driven by increasing R&D activities in pharmaceutical and agrochemical sectors. Market analysts note particular demand from Asia-Pacific regions, where generic drug manufacturing and agricultural chemical production are expanding rapidly. Current pricing trends reflect its status as a specialty chemical with high purity requirements for research applications.

Recent advancements in green chemistry have explored more sustainable synthesis routes for pyrazole-4-carboxylic acid derivatives. Researchers are investigating catalytic methods and alternative solvents to reduce the environmental impact of production processes. These developments align with growing industry focus on sustainable chemical manufacturing practices and circular economy principles.

Quality control of CAS 134589-59-6 typically involves HPLC analysis to ensure high purity levels required for research applications. Storage recommendations generally suggest keeping the compound in cool, dry conditions away from light to maintain stability. Proper handling procedures are essential, though it doesn't fall under hazardous material classifications that require special permits.

The future outlook for 3-Chloro-1H-pyrazole-4-carboxylic acid appears promising, with potential applications emerging in material science and coordination chemistry. Its structural features make it interesting for developing functional materials, including metal-organic frameworks (MOFs) and luminescent compounds. These expanding applications could drive further market growth in coming years.

For researchers sourcing 3-chloro-1H-pyrazole-4-carboxylic acid 134589-59-6, it's important to verify supplier credentials and request comprehensive analytical certificates. Reputable suppliers should provide detailed specifications including purity levels, impurity profiles, and batch-to-batch consistency data. These quality assurances are particularly critical for pharmaceutical intermediates where consistency directly impacts research outcomes.

In summary, 3-Chloro-1H-pyrazole-4-carboxylic acid represents an important chemical building block with diverse applications across multiple industries. Its value in drug discovery, agricultural chemistry, and material science continues to drive research interest and commercial demand. As synthetic methodologies advance and new applications emerge, this compound will likely maintain its relevance in chemical research and industrial applications for years to come.

• 51149-08-7(3,6-Dichloropyridazine-4-carboxylic acid)
• 137343-52-3(3-chloro-1-methyl-1H-pyrazole-4-carboxylic acid)
• 948552-01-0(Ethyl 5-chloro-1H-pyrazole-4-carboxylate)
• 1393667-83-8(ethyl 3-chloro-1H-pyrazole-4-carboxylate)
• 2089301-64-2(Methyl 3-chloro-1H-pyrazole-4-carboxylate)
• 1093414-62-0(3-chloro-5-methyl-1H-pyrazole-4-carboxylic acid)
• 134589-58-5(3,5-dichloro-1H-pyrazole-4-carboxylic acid)
• 1023307-42-7(3-chloropyridazine-4-carboxylic acid)
• 1186049-67-1(5-Chloro-1H-pyrazole-4-carboxylic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)