• 1. Enantiomorphic symmetry breaking in crystallization of molten sodium chlorate?
  Martin R. Ward,Gary W. Copeland,Andrew J. Alexander Chem. Commun., 2010,46, 7634-7636
• 2. Estimating and correcting interference fringes in infrared spectra in infrared hyperspectral imaging
  Ghazal Azarfar,Ebrahim Aboualizadeh,Nicholas M. Walter,Simona Ratti,Camilla Olivieri,Alessandra Norici,Michael Nasse,Achim Kohler,Mario Giordano Analyst, 2018,143, 4674-4683
• 3. Evidence of pre-micellar aggregates in aqueous solution of amphiphilic PDMS–PEO block copolymer?
  Domenico Lombardo,Gianmarco Munaò,Pietro Calandra,Luigi Pasqua,Maria Teresa Caccamo Phys. Chem. Chem. Phys., 2019,21, 11983-11991
• 4. Distribution and ecological risk assessment of typical antibiotics in the surface waters of seven major rivers, China?
  Environ. Sci.: Processes Impacts, 2021,23, 1088-1100
• 5. Fe3O4/FeS2 heterostructures enable efficient oxygen evolution reaction?
  Xingqun Zheng,Lele Song,Xin Feng,Li Li,Zidong Wei J. Mater. Chem. A, 2020,8, 14145-14151

Comprehensive Overview of 4-Aminopyridine-2-carbothioamide (CAS No. 1343641-19-9): Properties, Applications, and Research Insights

4-Aminopyridine-2-carbothioamide (CAS No. 1343641-19-9) is a specialized organic compound gaining attention in pharmaceutical and biochemical research due to its unique structural features. This compound, often referred to as 4-AP-2-carbothioamide, belongs to the aminopyridine family, which is known for its diverse biological activities. Researchers are particularly interested in its potential as a kinase inhibitor or enzyme modulator, aligning with current trends in targeted drug discovery.

The molecular structure of 4-Aminopyridine-2-carbothioamide combines a pyridine ring with an amino group at the 4-position and a carbothioamide moiety at the 2-position. This configuration contributes to its hydrogen-bonding capacity and metal-chelating properties, making it valuable for designing small-molecule probes in chemical biology. Recent studies highlight its relevance in neurodegenerative disease research, a hot topic in 2023-2024, where modulation of ion channels and enzymatic pathways is crucial.

From a synthetic chemistry perspective, CAS 1343641-19-9 serves as a versatile building block for heterocyclic compounds. Its thioamide group enables diverse transformations, including cyclization reactions to form thiazole derivatives—a class of compounds frequently explored in antibacterial and anticancer drug development. This aligns with growing public interest in antibiotic alternatives and personalized medicine, frequently searched topics in healthcare forums.

Analytical characterization of 4-Aminopyridine-2-carbothioamide typically involves HPLC purification and mass spectrometry verification, ensuring >95% purity for research applications. Stability studies indicate proper storage under nitrogen atmosphere at -20°C to preserve its chemical integrity—a critical consideration for laboratories focusing on reproducible research, another trending concern in scientific communities.

In material science, derivatives of 4-AP-2-carbothioamide show promise in developing organic semiconductors due to their electron-rich pyridine core. This connects with the booming interest in flexible electronics and sustainable energy solutions, frequently searched keywords in engineering databases. The compound's ability to coordinate with transition metals also makes it relevant for designing catalytic systems in green chemistry applications.

Safety assessments of CAS 1343641-19-9 emphasize standard laboratory precautions, including PPE compliance and fume hood usage. While not classified as hazardous under standard protocols, its handling follows GLP guidelines—a crucial point for institutions prioritizing lab safety culture, a subject of increasing online discussions among research professionals.

The commercial availability of 4-Aminopyridine-2-carbothioamide through specialty chemical suppliers has expanded in recent years, with pricing reflecting its high-purity grade status. Procurement trends show growing demand from biotech startups and academic research centers, particularly those investigating signal transduction pathways—a key phrase in contemporary molecular biology literature.

Future research directions for this compound may explore its structure-activity relationships in greater depth, especially regarding selective target engagement. Such studies could benefit from advanced techniques like cryo-EM or AI-assisted molecular docking, both being highly searched terms in computational chemistry circles. The integration of machine learning in compound optimization represents a natural progression for derivatives of this scaffold.

Environmental considerations for 4-Aminopyridine-2-carbothioamide include proper waste disposal through authorized chemical treatment facilities. Its biodegradation profile remains an active area of study, reflecting the broader scientific focus on green chemistry metrics—a trending topic in sustainability-focused research publications and conference proceedings.

In summary, 4-Aminopyridine-2-carbothioamide (CAS No. 1343641-19-9) represents a multifaceted research chemical with applications spanning medicinal chemistry, materials science, and chemical biology. Its growing prominence correlates with several cutting-edge scientific trends, including precision medicine, sustainable catalysis, and advanced material design—all areas generating substantial online search traffic among professionals and students alike.

• 5346-38-3(Pyridine-2-carbothioamide)
• 1347815-39-7(5-Aminopyridine-2-carbothioamide)
• 42242-12-6(3-Aminopyridine-2-carbothioamide)
• 5393-24-8(2,6-Pyridinedicarbothioamide)
• 17598-09-3(2-Pyridinecarbothioamide, N-methyl-)
• 37488-45-2(1H-Pyrrole-2-carbothioamide)
• 5933-30-2(6-Methylpicolinic Thionamide)
• 16225-37-9(4-methylpyridine-2-carbothioamide)
• 435273-39-5(1-Isoquinolinecarbothioamide)
• 61574-17-2(Pyridinecarbothioamide)