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  Pierre Sierocki,Krystal Gaillard,Ruben Arturo Arellano Reyes,Chloé Donnart,Emilie Lambert,Sandrine Grosse,Laurence Arzel,Arnaud Tessier,Jerome Guillemont,Monique Mathé-Allainmat,Jacques Lebreton Org. Biomol. Chem. 2022 20 2715
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  Pierre Sierocki,Krystal Gaillard,Ruben Arturo Arellano Reyes,Chloé Donnart,Emilie Lambert,Sandrine Grosse,Laurence Arzel,Arnaud Tessier,Jerome Guillemont,Monique Mathé-Allainmat,Jacques Lebreton Org. Biomol. Chem. 2022 20 2715
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  Pierre Sierocki,Krystal Gaillard,Ruben Arturo Arellano Reyes,Chloé Donnart,Emilie Lambert,Sandrine Grosse,Laurence Arzel,Arnaud Tessier,Jerome Guillemont,Monique Mathé-Allainmat,Jacques Lebreton Org. Biomol. Chem. 2022 20 2715
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Comprehensive Overview of 2-Methoxytetrahydrofuran (CAS No. 13436-45-8): Properties, Applications, and Industry Insights

2-Methoxytetrahydrofuran (CAS No. 13436-45-8), a versatile cyclic ether derivative, has garnered significant attention in pharmaceutical, agrochemical, and specialty chemical industries. This compound, often referred to as 2-MeOTHF or methoxy-THF, serves as a critical solvent and intermediate due to its unique molecular structure combining a tetrahydrofuran ring with a methoxy substituent. Its low toxicity, high stability, and excellent solvation properties make it a preferred choice for green chemistry applications, aligning with the global shift toward sustainable synthesis.

Recent trends highlight growing interest in bio-based solvents and eco-friendly alternatives to traditional reagents, positioning 2-Methoxytetrahydrofuran as a promising candidate. Searches for "biodegradable solvent substitutes" or "safe ether derivatives for pharmaceuticals" reflect this demand. The compound’s ability to dissolve polar and non-polar compounds while maintaining low volatility addresses key concerns in industrial safety and environmental compliance. Researchers also explore its role in asymmetric synthesis and catalysis, where its chiral center enables stereoselective reactions—a hot topic in drug development.

From a technical perspective, 2-Methoxytetrahydrofuran exhibits a boiling point of ~110–115°C and a density of ~0.95 g/cm3, making it suitable for high-temperature reactions. Its water-miscibility and low viscosity facilitate easy handling in liquid-phase processes. Analytical techniques like GC-MS and NMR spectroscopy confirm its purity, a critical factor for applications requiring high-precision formulations. Notably, its compatibility with Grignard reagents and organolithium compounds expands its utility in fine chemical synthesis.

In the pharmaceutical sector, 2-Methoxytetrahydrofuran is increasingly used as a reaction medium for APIs (Active Pharmaceutical Ingredients). Queries such as "solvents for peptide coupling" or "THF alternatives in drug formulation" underscore its relevance. Its low peroxidation risk compared to conventional THF reduces storage hazards, a key advantage for manufacturers prioritizing workplace safety. Additionally, agrochemical formulations leverage its solvation power for pesticides and herbicides, particularly in microencapsulation technologies that enhance product efficacy.

Innovations in green chemistry further propel the adoption of 2-Methoxytetrahydrofuran. With rising regulatory pressures on volatile organic compounds (VOCs), industries seek alternatives that meet REACH and EPA standards. The compound’s biodegradability profile and reduced environmental persistence align with these requirements. Recent patents highlight its use in ionic liquid systems and CO? capture technologies, demonstrating its cross-industry potential. As sustainability becomes a core focus, searches for "circular economy solvents" or "non-toxic reaction media" amplify its market visibility.

Quality control protocols for CAS No. 13436-45-8 emphasize stringent impurity thresholds, particularly for peroxide content and residual catalysts. Suppliers often provide HPLC-grade or anhydrous variants to cater to diverse industrial needs. Storage recommendations typically include nitrogen blanketing and amber glass containers to prevent degradation—a detail frequently queried in "best practices for ether storage" discussions. These measures ensure compliance with ICH guidelines for pharmaceutical applications.

Looking ahead, 2-Methoxytetrahydrofuran is poised to play a pivotal role in emerging fields like flow chemistry and continuous manufacturing. Its compatibility with microreactor systems and high-throughput screening aligns with Industry 4.0 automation trends. Furthermore, its potential in battery electrolyte formulations and polymer plasticizers opens new avenues for material science research. As industries prioritize carbon footprint reduction, this compound’s balance of performance and sustainability will likely drive its demand upward.

• 13436-46-9(Furan,2-ethoxytetrahydro-)
• 3320-90-9(Furan,2,5-diethoxytetrahydro-)
• 3658-79-5(1,1-Diethoxypentane)
• 5371-52-8(2-Hydroxytetrahydrofuran)
• 3658-93-3(1,1-Diethoxyhexane)
• 3658-95-5(1,1-diethoxybutane)
• 54815-13-3(Nonanal diethyl acetal)
• 696-59-3(2,5-dimethoxyoxolane)
• 53405-98-4(Dodecane, 1,1-diethoxy-)
• 18545-17-0(5,5-Diethoxypentan-1-ol)