• 1. Fe(ii)-Assisted one-pot synthesis of ultra-small core–shell Au–Pt nanoparticles as superior catalysts towards the HER and ORR?
  Yi Cao,Yujiao Xiahou,Lixiang Xing,Xiang Zhang,Hong Li,ChenShou Wu,Haibing Xia Nanoscale, 2020,12, 20456-20466
• 2. Excitation energies from ground-state density-functionals by means of generator coordinates
  A. B. F. da Silva,K. Capelle Phys. Chem. Chem. Phys., 2009,11, 4564-4569
• 3. Emerging enantiomeric resolution materials with homochiral nano-fabrications
  Ji-Ping Wei Nanoscale, 2015,7, 11815-11832
• 4. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
  Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
• 5. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?
  Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives

Introduction to Ethyl 3-amino-3-(oxan-3-yl)propanoate (CAS No. 1342165-88-1)

Ethyl 3-amino-3-(oxan-3-yl)propanoate, identified by its CAS number 1342165-88-1, is a significant compound in the realm of chemical and pharmaceutical research. This compound belongs to a class of molecules that exhibit intriguing structural and functional properties, making it a subject of considerable interest in both academic and industrial settings.

The molecular structure of ethyl 3-amino-3-(oxan-3-yl)propanoate features a unique combination of functional groups, including an amino group and an ester moiety, which are strategically positioned relative to an oxane ring. This configuration imparts distinct chemical reactivity and potential biological activity, making it a valuable scaffold for the development of novel pharmaceutical agents.

In recent years, there has been growing interest in the synthesis and characterization of this compound due to its potential applications in drug discovery. The oxane ring, a cyclic ether moiety, is known for its stability and ability to mimic certain biological functionalities, which makes it an attractive component in medicinal chemistry. The presence of both amino and ester groups further enhances its versatility, allowing for diverse chemical modifications and functionalization.

One of the most compelling aspects of ethyl 3-amino-3-(oxan-3-yl)propanoate is its role as a building block in the synthesis of more complex molecules. Researchers have leveraged its structural features to develop novel derivatives with enhanced pharmacological properties. For instance, the amino group can be readily incorporated into peptide mimetics or used as a site for covalent attachment to other biomolecules, while the ester group can be hydrolyzed to release active pharmaceutical ingredients (APIs).

The pharmaceutical industry has shown particular interest in this compound due to its potential as an intermediate in the synthesis of bioactive molecules. Studies have demonstrated its utility in the preparation of inhibitors targeting various therapeutic pathways. For example, derivatives of ethyl 3-amino-3-(oxan-3-yl)propanoate have been explored as potential kinase inhibitors, which are crucial in treating cancers and inflammatory diseases.

Moreover, the compound's ability to undergo selective modifications has made it a valuable tool in combinatorial chemistry and high-throughput screening (HTS) platforms. By systematically varying the substituents on the oxane ring and other functional groups, researchers can generate libraries of compounds with tailored properties. This approach has led to the discovery of several lead compounds with promising therapeutic effects.

In academic research, ethyl 3-amino-3-(oxan-3-yl)propanoate has been used to study the mechanisms of various biochemical pathways. Its unique structural features allow it to interact with biological targets in specific ways, providing insights into drug-receptor interactions and metabolic processes. Such studies are essential for understanding disease mechanisms and developing targeted therapies.

The synthesis of ethyl 3-amino-3-(oxan-3-yl)propanoate presents both challenges and opportunities for chemists. While the oxane ring adds complexity to the synthetic route, it also offers unique opportunities for stereoselective synthesis. Recent advances in catalytic methods have enabled more efficient and scalable production of this compound, making it more accessible for research purposes.

The future prospects for ethyl 3-amino-3-(oxan-3-ylopropanoate) are promising, with ongoing research exploring its potential applications in drug development and material science. As our understanding of its properties grows, so does its utility in creating innovative solutions for complex problems. Whether used as a starting material or as part of a larger molecular framework, this compound continues to captivate researchers with its versatility and potential.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)