• 1. Elusive 2-aminofuran Diels–Alder substrates for a straightforward synthesis of polysubstituted anilines?
  Ana G. Neo,Ana Bornadiego,Jesús Díaz,Stefano Marcaccini,Carlos F. Marcos Org. Biomol. Chem., 2013,11, 6546-6555
• 2. Evolutionary de novo design of phenothiazine derivatives for dye-sensitized solar cells?
  Vishwesh Venkatraman,Marco Foscato,Vidar R. Jensen,Bj?rn K?re Alsberg J. Mater. Chem. A, 2015,3, 9851-9860
• 3. Enabling shape memory and healable effects in a conjugated polymer by incorporating siloxane via dynamic imine bond?
  Yaling Zhang,Chunhui Dai,Shiwei Zhou,Bin Liu Chem. Commun., 2018,54, 10092-10095
• 4. Emulsifier-free, organotellurium-mediated living radical emulsion polymerization (emulsion TERP) of styrene: poly(dimethylaminoethyl methacrylate) macro-TERP agent?
  Yukiya Kitayama Polym. Chem., 2014,5, 2784-2792
• 5. Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries?
  Zhiyan Chen,Nan Wu,Yaobing Wang,Bing Wang,Yingde Wang J. Mater. Chem. A, 2018,6, 516-526

Introduction to 3-(p-Tolyl)pyridin-4-amine (CAS No. 1341149-33-4)

3-(p-Tolyl)pyridin-4-amine, identified by the Chemical Abstracts Service Number (CAS No.) 1341149-33-4, is a significant compound in the realm of pharmaceutical and chemical research. This heterocyclic amine derivative features a pyridine core substituted with a para-tolyl group at the 3-position and an amine functional group at the 4-position. Its unique structural configuration makes it a valuable intermediate in the synthesis of various biologically active molecules, particularly in the development of novel therapeutic agents.

The molecular structure of 3-(p-Tolyl)pyridin-4-amine contributes to its versatility as a building block in medicinal chemistry. The pyridine ring, known for its electron-deficient nature, interacts favorably with biological targets such as enzymes and receptors. The presence of the amine group at the 4-position enhances its reactivity, allowing for further functionalization through condensation, alkylation, or acylation reactions. These properties make it a preferred choice for researchers seeking to develop small-molecule inhibitors or modulators.

In recent years, there has been growing interest in exploring the pharmacological potential of 3-(p-Tolyl)pyridin-4-amine and its derivatives. One notable area of research involves its application in the development of kinase inhibitors, which are crucial in treating cancers and inflammatory diseases. The pyridine moiety's ability to mimic ATP binding pockets in kinases has been exploited to design highly specific inhibitors. For instance, studies have demonstrated that analogs of 3-(p-Tolyl)pyridin-4-amine can disrupt aberrant signaling pathways by competitively inhibiting key tyrosine kinases.

Furthermore, the compound has shown promise in the field of neurology. Researchers have investigated its potential as a precursor for drugs targeting neurological disorders such as Alzheimer's disease and Parkinson's disease. The amine group in 3-(p-Tolyl)pyridin-4-amine allows for facile derivatization into structures that can interact with neurotransmitter receptors or enzymes involved in neurodegeneration. Preliminary studies suggest that certain derivatives may exhibit neuroprotective effects by modulating oxidative stress and inflammation.

The synthesis of 3-(p-Tolyl)pyridin-4-amine typically involves multi-step organic reactions, starting from commercially available pyridine derivatives and aromatic amines. Advanced synthetic methodologies, such as palladium-catalyzed cross-coupling reactions, have been employed to achieve high yields and purity. These synthetic routes highlight the compound's accessibility for industrial-scale production, ensuring its availability for further research and development.

From a computational chemistry perspective, 3-(p-Tolyl)pyridin-4-amine has been extensively studied using molecular modeling techniques. These studies aim to elucidate its binding interactions with biological targets at an atomic level. By leveraging computational tools, researchers can predict the compound's affinity for specific receptors or enzymes, thereby guiding the design of more effective drug candidates. Such virtual screening approaches have accelerated the discovery process in drug development pipelines.

The safety profile of 3-(p-Tolyl)pyridin-4-amine is another critical aspect that has been thoroughly evaluated. Toxicological studies have been conducted to assess its acute and chronic effects on living organisms. These investigations focus on parameters such as solubility, bioavailability, and metabolic stability, which are essential for determining its suitability as a pharmaceutical intermediate. The results from these studies indicate that 3-(p-Tolyl)pyridin-4-amine is well-tolerated at moderate concentrations but may require careful handling due to potential irritant properties.

In conclusion,3-(p-Tolyl)pyridin-4-amine (CAS No. 1341149-33-4) represents a compelling candidate for further exploration in pharmaceutical research. Its structural features and reactivity make it an indispensable tool for synthesizing novel therapeutic agents targeting various diseases. With ongoing advancements in synthetic chemistry and computational biology,3-(p-Tolyl)pyridin-4-amine is poised to play a pivotal role in shaping the future of drug discovery and development.

• 1214379-46-0(3-(pyridin-4-yl)pyridin-4-amine)
• 1339667-18-3(3-(m-Tolyl)pyridin-4-amine)
• 1214333-30-8([3,3'-Bipyridin]-4-amine)
• 177202-83-4(2-(Pyridin-3-yl)aniline)
• 1341622-75-0(3-(o-Tolyl)pyridin-4-amine)
• 1211524-38-7(3-Phenylpyridin-4-amine)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)