• 1. Fe3O4/PEG-SO3H as a heterogeneous and magnetically-recyclable nanocatalyst for the oxidation of sulfides to sulfones or sulfoxides
  Saeideh Mirfakhraei,Malak Hekmati,Fereshteh Hosseini Eshbala,Hojat Veisi New J. Chem., 2018,42, 1757-1761
• 2. Exceptionally high temperature spin crossover in amide-functionalised 2,6-bis(pyrazol-1-yl)pyridine iron(ii) complex revealed by variable temperature Raman spectroscopy and single crystal X-ray diffraction?
  Max Attwood,Hiroki Akutsu,Lee Martin,Toby J. Blundell,Pierre Le Maguere,Scott S. Turner Dalton Trans., 2021,50, 11843-11851
• 3. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
• 4. Excellent energy storage performance in NaNbO3-based relaxor antiferroeic ceramics under a low electric field
  XuxinCheng,XiaomingChen,PengyuanFan
• 5. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Trifluoromethylbenzenes

Introduction to 2,6-Difluoro-4-(trifluoromethyl)benzaldehyde (CAS No. 134099-34-6)

2,6-Difluoro-4-(trifluoromethyl)benzaldehyde, identified by its Chemical Abstracts Service (CAS) number 134099-34-6, is a fluorinated aromatic aldehyde that has garnered significant attention in the field of pharmaceutical and agrochemical research. This compound, characterized by its dual fluorine substituents at the 2- and 6-positions and a trifluoromethyl group at the 4-position, exhibits unique chemical properties that make it a valuable intermediate in synthetic chemistry. The presence of these fluorine atoms imparts enhanced metabolic stability and lipophilicity, which are critical factors in drug design and development.

The structural features of 2,6-Difluoro-4-(trifluoromethyl)benzaldehyde contribute to its versatility in organic synthesis. The aldehyde functional group provides a reactive site for further functionalization, enabling the construction of more complex molecular architectures. This property is particularly useful in the synthesis of heterocyclic compounds, which are prevalent in many bioactive molecules. The fluorinated aromatic ring system also influences the electronic properties of the molecule, making it a suitable candidate for applications in materials science and catalysis.

In recent years, there has been a growing interest in fluorinated compounds due to their pronounced biological activity and improved pharmacokinetic profiles. Studies have demonstrated that fluorine atoms can modulate the binding affinity of molecules to their targets, leading to enhanced therapeutic efficacy. For instance, 2,6-Difluoro-4-(trifluoromethyl)benzaldehyde has been explored as a key intermediate in the synthesis of kinase inhibitors, which are widely used in the treatment of cancers and inflammatory diseases. The trifluoromethyl group, in particular, is known to increase the metabolic stability of drug candidates by resisting oxidative degradation.

The pharmaceutical industry has leveraged the synthetic utility of 2,6-Difluoro-4-(trifluoromethyl)benzaldehyde to develop novel therapeutic agents. Researchers have utilized this compound to construct scaffolds for small-molecule drugs that target specific biological pathways. For example, derivatives of this benzaldehyde have been investigated for their potential antiviral and antibacterial properties. The ability to introduce diverse functional groups while maintaining the core fluorinated aromatic structure allows for rapid screening and optimization of drug candidates.

Advances in computational chemistry have further enhanced the understanding of how 2,6-Difluoro-4-(trifluoromethyl)benzaldehyde interacts with biological targets. Molecular modeling studies have revealed that the fluorine atoms can engage in favorable interactions with polar residues in proteins, thereby improving binding affinity. Additionally, computational methods have been used to predict the metabolic fate of this compound, providing insights into its potential toxicity profile. These findings are crucial for guiding the development of safe and effective drugs.

The agrochemical sector has also benefited from the use of 2,6-Difluoro-4-(trifluoromethyl)benzaldehyde as an intermediate. Fluorinated compounds are known for their enhanced stability against environmental degradation, making them ideal candidates for use in pesticides and herbicides. Researchers have synthesized various derivatives of this benzaldehyde to develop novel agrochemicals that offer improved efficacy while minimizing environmental impact. The dual fluorine substituents contribute to the lipophilicity of these compounds, ensuring better absorption and translocation within plant tissues.

The synthesis of 2,6-Difluoro-4-(trifluoromethyl)benzaldehyde involves multi-step organic reactions that require careful optimization to achieve high yields and purity. Common synthetic routes include Friedel-Crafts acylation followed by reduction and selective fluorination. Advances in catalytic methods have enabled more efficient and sustainable production processes. For instance, transition metal-catalyzed cross-coupling reactions have been employed to introduce fluorine atoms with high selectivity. These innovations not only improve the efficiency of synthesis but also reduce waste generation.

The safety profile of 2,6-Difluoro-4-(trifluoromethyl)benzaldehyde is another critical consideration in its application. While this compound is not classified as hazardous under standard conditions, proper handling procedures must be followed to minimize exposure risks. Personal protective equipment (PPE), such as gloves and safety goggles, should be used when handling this substance in laboratory settings. Additionally, adequate ventilation is essential to prevent inhalation of any vapors that may be generated during its use.

In conclusion, 2,6-Difluoro-4-(trifluoromethyl)benzaldehyde (CAS No. 134099-34-6) is a multifaceted compound with significant potential in pharmaceuticals and agrochemicals. Its unique structural features make it a valuable intermediate for synthesizing bioactive molecules with improved pharmacokinetic properties. Ongoing research continues to uncover new applications for this compound, underscoring its importance in modern chemistry.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)