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• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers Phenol ethers
• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers

Introduction to 2-4-(2-methylpropoxy)phenylacetic acid (CAS No. 13362-94-2)

2-4-(2-methylpropoxy)phenylacetic acid, identified by the Chemical Abstracts Service registry number 13362-94-2, is a specialized organic compound that has garnered significant attention in the field of pharmaceutical research and chemical synthesis. This compound, featuring a phenylacetic acid backbone substituted with a 2-methylpropoxy group at the 2- and 4-positions of the aromatic ring, exhibits unique structural and functional properties that make it a valuable intermediate in the development of novel therapeutic agents.

The molecular structure of 2-4-(2-methylpropoxy)phenylacetic acid consists of a benzene ring linked to an acetic acid moiety, with two methylpropoxy (isobutoxy) side chains attached at the 2nd and 4th carbon atoms. This arrangement imparts both lipophilicity and metabolic stability, characteristics that are highly desirable in drug design. The presence of the isobutoxy groups enhances the compound's solubility in both aqueous and organic solvents, facilitating its use in a wide range of chemical reactions and formulations.

In recent years, 2-4-(2-methylpropoxy)phenylacetic acid has been extensively studied for its potential applications in medicinal chemistry. Its structural motif is reminiscent of several known bioactive molecules, suggesting that it may serve as a precursor or analog for drugs targeting various biological pathways. Notably, phenylacetic acid derivatives have been implicated in processes such as neurotransmitter modulation, inflammation regulation, and metabolic control, areas where this compound shows promise.

One of the most compelling aspects of CAS No. 13362-94-2 is its role as a building block in the synthesis of more complex pharmacophores. Researchers have leveraged its reactive sites—primarily the carboxylic acid group and the aromatic ring—to introduce additional functional modifications. For instance, its carboxylate functionality can be esterified or amidated to create derivatives with enhanced bioavailability or targeted tissue distribution. The aromatic ring also offers opportunities for further substitution, allowing for the exploration of diverse chemical libraries.

Recent advancements in computational chemistry have enabled more efficient virtual screening of compounds like 2-4-(2-methylpropoxy)phenylacetic acid. By integrating machine learning algorithms with traditional pharmacophore modeling, scientists can predict the binding affinity of this compound to specific biological targets with remarkable accuracy. This approach has accelerated the discovery pipeline for potential drug candidates derived from this scaffold.

The synthesis of CAS No. 13362-94-2 typically involves multi-step organic transformations starting from commercially available precursors such as p-toluidine and isobutyraldehyde. The reaction sequence often includes etherification followed by acetylation or carboxylation steps to achieve the desired substitution pattern. Optimizing these synthetic routes is crucial for ensuring high yield and purity, which are essential for subsequent pharmaceutical applications.

In addition to its synthetic utility, 2-4-(2-methylpropoxy)phenylacetic acid has been investigated for its potential role in drug delivery systems. Its amphiphilic nature allows it to form micelles or nanoparticles when combined with appropriate surfactants or polymers. These formulations can enhance the solubility and targeted release of co-administered therapeutics, making them particularly relevant for treatments requiring controlled release profiles.

Emerging research also suggests that derivatives of CAS No. 13362-94-2 may exhibit anti-inflammatory properties. Phenylacetic acid derivatives are known to modulate pathways involving interleukin-10 (IL-10) production and other cytokines that play a critical role in immune responses. By structurally modifying 2-4-(2-methylpropoxy)phenylacetic acid, researchers aim to develop novel agents that can selectively inhibit inflammatory processes without compromising host defense mechanisms.

The pharmacokinetic profile of compounds derived from CAS No. 13362-94-2 is another area of active investigation. Studies indicate that the methylpropoxy groups contribute to prolonged circulation times by reducing metabolic clearance rates. This characteristic could be exploited to develop long-lasting treatments for chronic conditions where frequent dosing would be impractical.

Industrial-scale production of CAS No. 13362-94-2 requires stringent quality control measures to ensure consistency across batches. Analytical techniques such as high-performance liquid chromatography (HPLC), nuclear magnetic resonance (NMR) spectroscopy, and mass spectrometry (MS) are employed to verify purity and structural integrity. These methods are essential for meeting regulatory standards set forth by pharmaceutical agencies worldwide.

The versatility of CAS No. 13362-94-2 extends beyond medicinal chemistry into agrochemical research and material science applications. Its ability to undergo cross-coupling reactions makes it a valuable precursor for synthesizing complex organic molecules used in crop protection agents or specialty polymers.

In conclusion,CAS No 13362 -94 - 2, corresponding to 2 -4 - ( 2 -methylpropoxy ) phenylacetic acid, represents a multifaceted compound with broad utility across multiple scientific disciplines Its unique structural features offer opportunities for innovation in drug discovery synthesis nanotechnology and beyond As research continues into its applications scientists anticipate uncovering even more ways this versatile molecule can contribute to advancing human health and industrial progress

• 20797-54-0(bis(4-ethoxyphenyl)acetic acid)
• 144236-88-4(Benzeneacetic acid,4-(2-hydroxyethoxy)-a-methyl-)
• 61888-58-2([1,1'-Biphenyl]-3-aceticacid, 5-(2-methylpropoxy)-)
• 61904-54-9(Benzeneacetic acid, 4-(2-methylpropoxy)-, methyl ester)
• 51028-86-5([3-methyl-5-(2-methylpropoxy)phenyl]acetic acid)
• 887360-10-3(4-(2-Phenylethoxy)PhenylAcetic Acid)
• 72775-83-8((3-Ethoxyphenyl)acetic acid)
• 64464-73-9(Benzeneacetic acid, α-(phenoxymethyl)-)
• 117356-47-5(2-Naphthaleneaceticacid, 7-propoxy-)
• 86521-64-4(2-(4-ethoxyphenyl)-2-methylpropanoic acid)