Cas no 133367-34-7 (fmoc-his(mtt)-oh)
FMOC-His(Mtt)-OH is a protected derivative of histidine, widely used in solid-phase peptide synthesis (SPPS). The Fmoc (9-fluorenylmethoxycarbonyl) group serves as a temporary α-amino protector, while the Mtt (4-methyltrityl) group selectively shields the imidazole side chain of histidine. This dual protection ensures orthogonal deprotection strategies, enabling precise sequential assembly of peptides. The Mtt group is acid-labile, allowing mild cleavage conditions that minimize side reactions. FMOC-His(Mtt)-OH is particularly valuable in synthesizing complex peptides requiring selective side-chain deprotection. Its high purity and stability under SPPS conditions make it a reliable choice for researchers aiming to achieve efficient and controlled peptide elongation.
fmoc-his(mtt)-oh structure
Product Name:fmoc-his(mtt)-oh
CAS No:133367-34-7
MF:C41H35N3O4
MW:633.734310388565
MDL:MFCD00153358
CID:899543
Update Time:2025-05-27
fmoc-his(mtt)-oh Chemical and Physical Properties
Names and Identifiers
-
- fmoc-his(mtt)-oh
- (FMOC-HIS(MTT)-OH)
- Fmoc-His(1-Mtt)-OH
- Fmoc-L-His(Mtt)-OH
- 47526_FLUKA
- A-Fmoc-N(im)-(4-methyltrityl)-L-histidine
- AmbotzFAA1080
- CTK8E7397
- FT-0629899
- Nalpha-Fmoc-N(im)-(4-methyltrityl)-L-histidine
- FMoc-His(t-Mtt)-OH
- Fmoc-His(tau-Mtt)-OH
- FMOC-HISTIDINE(MTT)-OH
- FMOC-N-IM-METHYLTRITYL-L-HISTIDINE
- N(ALPHA)-FMOC-N(IM)-(4-METHYLTRITYL)-
- N-ALPHA-FMOC-N-IM-METHYLTRITYL-L-HISTIDINE
- nα-fmoc-n(im)-(4-methyltrityl)-l-histidine
-
- MDL： MFCD00153358
- Inchi： 1S/C41H35N3O4/c1-28-20-22-31(23-21-28)41(29-12-4-2-5-13-29,30-14-6-3-7-15-30)44-25-32(42-27-44)24-38(39(45)46)43-40(47)48-26-37-35-18-10-8-16-33(35)34-17-9-11-19-36(34)37/h2-23,25,27,37-38H,24,26H2,1H3,(H,43,47)(H,45,46)/t38-/m0/s1
- InChI Key： MNOCIIYDYLYWEU-LHEWISCISA-N
- SMILES： O(C(N[C@H](C(=O)O)CC1=CN(C=N1)C(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC(C)=CC=1)=O)CC1C2C=CC=CC=2C2=CC=CC=C12
Computed Properties
- Exact Mass: 633.26295
- Hydrogen Bond Donor Count: 2
- Hydrogen Bond Acceptor Count: 7
- Heavy Atom Count: 48
- Rotatable Bond Count: 12
Experimental Properties
- PSA: 93.45
- LogP: 7.95700
fmoc-his(mtt)-oh Security Information
- WGK Germany：3
- Safety Instruction： 22-24/25
- Storage Condition：2-8°C
fmoc-his(mtt)-oh Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| TRC | F657680-50mg |
FMOC-HIS(MTT)-OH |
133367-34-7 | 50mg |
$ 50.00 | 2022-06-04 | ||
| TRC | F657680-100mg |
FMOC-HIS(MTT)-OH |
133367-34-7 | 100mg |
$ 65.00 | 2022-06-04 | ||
| TRC | F657680-500mg |
FMOC-HIS(MTT)-OH |
133367-34-7 | 500mg |
$ 80.00 | 2022-06-04 | ||
| AAPPTec | AFH125-25g |
Fmoc-His(Mtt)-OH |
133367-34-7 | 25g |
$380.00 | 2024-07-19 | ||
| AAPPTec | AFH125-5g |
Fmoc-His(Mtt)-OH |
133367-34-7 | 5g |
$95.00 | 2024-07-19 | ||
| abcr | AB155836-25 g |
N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-im-p-methyltrityl-L-histidine; 99% |
133367-34-7 | 25g |
€210.00 | 2022-06-11 | ||
| abcr | AB155836-100 g |
N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-im-p-methyltrityl-L-histidine; 99% |
133367-34-7 | 100g |
€750.00 | 2022-06-11 | ||
| eNovation Chemicals LLC | D768168-2g |
L-Histidine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-1-[(4-methylphenyl)diphenylmethyl]- |
133367-34-7 | 95% | 2g |
$210 | 2023-05-18 | |
| eNovation Chemicals LLC | D768168-5g |
L-Histidine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-1-[(4-methylphenyl)diphenylmethyl]- |
133367-34-7 | 95% | 5g |
$180 | 2024-06-08 | |
| eNovation Chemicals LLC | D768168-10g |
L-Histidine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-1-[(4-methylphenyl)diphenylmethyl]- |
133367-34-7 | 95% | 10g |
$235 | 2024-06-08 |
fmoc-his(mtt)-oh Related Literature
-
Adeline Huiling Loo,Alessandra Bonanni,Martin Pumera Analyst, 2013,138, 467-471
-
Huabin Zhang,Shaowu Du CrystEngComm, 2014,16, 4059-4068
-
Zhonghua Xiang,Chuanqi Fang,Sanhua Leng,Dapeng Cao J. Mater. Chem. A, 2014,2, 7662-7665
-
Kanjun Sun,Fengting Hua,Shuzhen Cui,Yanrong Zhu,Hui Peng,Guofu Ma RSC Adv., 2021,11, 37631-37642
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