• 1. Enabling stable MnO2 matrix for aqueous zinc-ion battery cathodes?
  Yiding Jiao,Liqun Kang,Jasper Berry-Gair,Kit McColl,Jianwei Li,Haobo Dong,Hao Jiang,Ryan Wang,Furio Corà,Dan J. L. Brett,Ivan P. Parkin J. Mater. Chem. A, 2020,8, 22075-22082
• 2. Emerging investigator series: first-principles and thermodynamics comparison of compositionally-tuned delafossites: cation release from the (001) surface of complex metal oxides?
  Joseph W. Bennett,Diamond T. Jones,Blake G. Hudson,Joshua Melendez-Rivera,Robert J. Hamers,Sara E. Mason Environ. Sci.: Nano, 2020,7, 1642-1651
• 3. Excimer and exciplex formation in a pair of bright phosphorescent isomers constructed from Cu3(pyrazolate)3 and Cu3I3 coordination luminophores?
  Shun-Ze Zhan,Mian Li,Xiao-Ping Zhou,Dan Li,Seik Weng Ng RSC Adv., 2011,1, 1457-1459
• 4. Excitation energies from ground-state density-functionals by means of generator coordinates
  A. B. F. da Silva,K. Capelle Phys. Chem. Chem. Phys., 2009,11, 4564-4569
• 5. Dissolved oxygen sensor based on fluorescence quenching of oxygen-sensitive ruthenium complexes immobilized in sol–gel-derived porous silica coatings
  Analyst, 1996,121, 785-788

• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Fatty Acyls Fatty acid esters

Introduction to 2-hydroxypropyl (9E)-octadec-9-enoate (CAS No. 1330-80-9)

2-hydroxypropyl (9E)-octadec-9-enoate, with the chemical identifier CAS No. 1330-80-9, is a specialized compound that has garnered significant attention in the field of pharmaceuticals and biotechnology due to its unique structural and functional properties. This compound, characterized by its hydroxyl and enoate functional groups, exhibits promising applications in drug delivery systems, lipid-based formulations, and as an excipient in pharmaceutical formulations. The molecular structure of 2-hydroxypropyl (9E)-octadec-9-enoate consists of an octadecene backbone with a hydroxyl group attached to the second carbon and an enoate ester linkage, which contributes to its solubility and stability in various media.

The compound’s versatility stems from its ability to interact with both hydrophilic and lipophilic environments, making it an excellent candidate for use in nanocarrier systems such as liposomes and micelles. These properties are particularly relevant in the context of targeted drug delivery, where the compound can enhance the bioavailability of therapeutic agents by improving their solubility and protecting them from degradation. Recent studies have highlighted the potential of 2-hydroxypropyl (9E)-octadec-9-enoate in enhancing the permeability of biological membranes, which could lead to more efficient absorption of drugs across cellular barriers.

In the realm of pharmaceutical research, 2-hydroxypropyl (9E)-octadec-9-enoate has been explored for its role as a stabilizing agent in liquid crystal formulations. Its ability to form stable mesophases at elevated temperatures makes it useful in developing thermoreversible gels for controlled-release applications. This property is particularly valuable in creating temperature-sensitive drug delivery systems that can release therapeutic agents in response to physiological changes, such as those experienced during hyperthermia treatments.

Moreover, the compound’s enoate group provides a site for further chemical modification, enabling the synthesis of derivatives with tailored functionalities. For instance, researchers have investigated its use as a precursor for biodegradable polymers that can be employed in scaffold-based tissue engineering applications. The hydroxyl group also allows for conjugation with biomolecules, such as peptides or proteins, facilitating the development of prodrugs or targeted therapeutic agents.

Recent advancements in computational chemistry have further elucidated the interactions between 2-hydroxypropyl (9E)-octadec-9-enoate and biological targets. Molecular dynamics simulations have shown that this compound can form stable complexes with certain membrane proteins, potentially modulating their activity. Such insights are crucial for designing drugs that interact selectively with specific biological pathways, thereby minimizing side effects and improving therapeutic outcomes.

The compound’s role in lipid-based drug delivery systems has also been extensively studied. By incorporating 2-hydroxypropyl (9E)-octadec-9-enoate into phospholipid bilayers, researchers have developed novel liposomes capable of prolonged circulation times within the bloodstream. This extended half-life is particularly advantageous for treatments requiring repeated dosing or long-term therapeutic effects. Additionally, the compound’s compatibility with other lipid components ensures that it does not interfere with the integrity or functionality of these delivery systems.

In conclusion, 2-hydroxypropyl (9E)-octadec-9-enoate (CAS No. 1330-80-9) represents a multifaceted compound with broad applications in pharmaceutical science. Its unique structural features enable its use in drug delivery systems, stabilizing agents for liquid crystal formulations, and as a precursor for biodegradable polymers. The ongoing research into its interactions with biological systems continues to uncover new possibilities for therapeutic applications, making it a valuable asset in the development of next-generation pharmaceuticals.

• 79665-95-5(triglycerol trioleate)
• 155808-79-0(POLYGLYCERYL-10 NONAERUCATE)
• 85049-34-9(fatty acids, c16-18 and c18-unsatd., esters with propylene glycol)
• 68609-92-7(9-Octadecenoic acid (9Z)-, epoxidized, ester with propylene glycol)
• 85186-52-3(9-Octadecenoic acid (Z)-, monoester with 1,2,3-propanetriol acetate)
• 9041-07-0(Decaglycerin)
• 4813-60-9(9-Octadecenoic acid(9Z)-, 2,2-bis(hydroxymethyl)butyl ester)
• 59981-83-8((9E,12RS,13RS)-12,13-Dihydroxy-9-octadecenoic acid)
• 37220-82-9(Witafrol 7470)
• 91782-95-5(9-octadecenoic acid (z)-, di- and triesters with glycerol)