Cas no 133-67-5 (Trichlormethiazide)

Trichlormethiazide is a thiazide diuretic primarily used to manage hypertension and edema associated with conditions such as congestive heart failure, renal dysfunction, or liver cirrhosis. Its mechanism of action involves inhibiting the sodium-chloride symporter in the distal convoluted tubule, promoting natriuresis and diuresis. The compound exhibits a well-characterized pharmacokinetic profile, with rapid absorption and a duration of action suitable for once-daily dosing. Key advantages include its efficacy in reducing blood pressure, compatibility with combination therapies, and a well-established safety profile when used as directed. Trichlormethiazide is also noted for its cost-effectiveness in long-term treatment regimens. Proper monitoring of electrolytes is recommended during therapy.
Trichlormethiazide structure
Trichlormethiazide structure
Product Name:Trichlormethiazide
CAS No:133-67-5
MF:C8H8Cl3N3O4S2
MW:380.655816078186
MDL:MFCD00057315
CID:153603
PubChem ID:87577089
Update Time:2025-06-07

Trichlormethiazide Chemical and Physical Properties

Names and Identifiers

    • Trichlormethiazide
    • Hydrotrichlorothiazide
    • Trichloromethiazide
    • 2H-1,2,4-Benzothiadiazine-7-sulfonamide,6-chloro-3-(dichloromethyl)-3,4-dihydro-, 1,1-dioxide
    • IDE-8 ≥98
    • 3-Dichloromethyl-6-chloro-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide
    • 6-chloro-3-(dichloromethyl)-1,1-dioxo-3,4-dihydro-2H-1λ6,2,4-benzothiadiazine-7-sulfonamide
    • 6-Chloro-3-dichloromethyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-Dioxide
    • Achletin,Diu-Hydrin,Triflumen
    • Metahydrin
    • Naqua
    • Trichlorex
    • 6-Chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide (+/-)-
    • NSC 61560
    • 6-Chloro-3-(dichloromethyl)-3,4-dihydro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide
    • Nakva
    • Navis
    • Nydor
    • Flutra
    • Natril
    • Pluvex
    • Diurese
    • Esmarin
    • Eurinol
    • Trichlormetazid
    • Achletin
    • Trichlormethiazid
    • Diu-Hydrin
    • Chlopolidine
    • Schebitran
    • Intromene
    • Gangesol
    • Diuroral
    • Aponorin
    • Cretonin
    • Triflumen
    • Isestran
    • Fluitran
    • Diurazida
    • Flurese
    • Triclordiuride
    • Tachionin
    • Kubacron
    • Tolcasone
    • Carvacron
    • Anistadin
    • Triclormetiazide
    • Trichloromethiadiazide
    • Metatensin
    • Trichlormas
    • Trichlordiuride
    • Triclormetiazida
    • Ciba 7057-Su
    • Salurin (wadel)
    • Trich
    • 6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide
    • NAQUIVAL COMPONENT TRICHLORMETHIAZIDE
    • Trichlormethiazide Metahydrin Naqua Trichlorex
    • SW197095-3
    • TRICHLORMETHIAZIDE [USP-RS]
    • Opera_ID_1588
    • Trichlormethiazide, United States Pharmacopeia (USP) Reference Standard
    • DTXCID803699
    • METATENSIN COMPONENT TRICHLORMETHIAZIDE
    • 6-Chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
    • KBioGR_000833
    • Tox21_110421
    • AB00052117_17
    • 6-Chloro-3-(dichloromethyl)3,2,4-benzothiadiazine-1,1-dioxide
    • SPECTRUM1500590
    • NCGC00018302-03
    • Q58C92TUN0
    • NCIOpen2_007750
    • T1318
    • 6-chloro-3-(dichloromethyl)-1,1-dioxo-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide
    • Prestwick_1020
    • Q2072745
    • s1667
    • Triclormetiazida (INN-Spanish)
    • TRICHLORMETHIAZIDE [HSDB]
    • BSPBio_002926
    • Z1562203528
    • TRICHLORMETHIAZIDE [USP MONOGRAPH]
    • 3-Dichloromethylhydrochlorothiazide
    • TRICHLORMETHIAZIDE [MI]
    • Prestwick0_000825
    • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(dichloromethyl)-3,4-dihydro-, 1,1-dioxide, (+-)-
    • NCGC00018302-08
    • HMS2235K21
    • Naqua (TN)
    • MLS000028705
    • 6-chloro-3-(dichloromethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide
    • 6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide
    • Naquasone
    • HMS3371B09
    • WLN: T66 BSWM EM DHJ DYGG HG ISZW
    • 6-Chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-thiadiazine-7-sulfonamide 1,1-dioxide
    • 6-chloro-3-(dichloromethyl)-3,4-dihydro-2h-1,2,4-benzothiadiazine-7-sulfonamid
    • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(dichloromethyl)-3,4-dihydro-, 1,1-dioxide
    • BRN 0629145
    • AS-56976
    • HSDB 3406
    • 3-(Dichloromethyl)-6-chloro-7-sulfamoyl-3,2,4-benzothiadiazine-1,1-dioxide
    • CHEBI:9683
    • SPBio_000916
    • (+/-)-6-CHLORO-3-(DICHLOROMETHYL)-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE
    • SBI-0051544.P002
    • TRICHLORMETHIAZIDE COMPONENT OF METATENSIN
    • MFCD00057315
    • 133-67-5
    • HMS2097F11
    • 6-chloro-3-(dichloromethyl)-1,1-dioxo-3,4-dihydro-2H-1??,2,4-benzothiadiazine-7-sulfonamide
    • SMR000058712
    • BRD-A28940325-001-15-8
    • KBio2_001000
    • TRICHLORMETHIAZIDE COMPONENT OF NAQUIVAL
    • Spectrum3_001373
    • A908323
    • TRICHLORMETHIAZIDE (MART.)
    • Spectrum4_000367
    • TRICHLORMETHIAZIDE [INN]
    • C07767
    • Prestwick3_000825
    • BSPBio_000749
    • CAS-133-67-5
    • HMS2090G08
    • SR-01000000284
    • TRICHLORMETHIAZIDE [ORANGE BOOK]
    • NCGC00018302-02
    • NS00009500
    • 1ST10693
    • KBio2_006136
    • 2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE, 6-CHLORO-3-(DICHLOROMETHYL)-3,4-DIHYDRO-, 1,1-DIOXIDE, (+/-)-
    • SCHEMBL25492
    • Triclormetiazide [DCIT]
    • Trichlormethiazide [USP:INN:JAN]
    • Spectrum2_000948
    • IDI1_000366
    • SR-01000000284-4
    • HMS3714F11
    • NCGC00089756-03
    • NCGC00018302-07
    • NSC757368
    • DB01021
    • NSC-61560
    • Trichlormethiazide, >=98%
    • HMS501C08
    • Pharmakon1600-01500590
    • Trichlormethiazidum (INN-Latin)
    • TRICHLORMETHIAZIDE (USP-RS)
    • 6-chloro-3-dichloromethyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide
    • TRICHLORMETHIAZIDE [MART.]
    • TRICHLORMETHIAZIDE [JAN]
    • 3-(Dichloromethyl)-6-chloro-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide
    • HMS3655I17
    • Spectrum_000520
    • DTXSID7023699
    • 2H-1,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(dichloromethyl)-3,4-dihydro-, 1,1-dioxide
    • UNII-Q58C92TUN0
    • 3-Dichloromethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-dioxide
    • BPBio1_000825
    • TRICHLORMETHIAZIDE [GREEN BOOK]
    • DivK1c_000366
    • NCGC00089756-02
    • Trichlormethiazide (JP17/USP/INN)
    • Prestwick1_000825
    • 6-CHLORO-3-(DICHLOROMETHYL)-3,4-DIHYDRO-2H-1,2,4-BENZO THIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE
    • (+-)-6-Chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
    • 3-Dichloromethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide
    • CHEMBL1054
    • MLS001076545
    • EINECS 205-118-8
    • AB00052117
    • LMJSLTNSBFUCMU-UHFFFAOYSA-N
    • trichloromethiazide, 6
    • GTPL7314
    • NCGC00016398-01
    • AKOS024374993
    • SPBio_002670
    • FT-0746865
    • AB00052117-15
    • BDBM26998
    • D00658
    • NCGC00018302-04
    • TRICHLORMETHIAZIDE [WHO-DD]
    • HMS2092O19
    • HMS1570F11
    • KBio1_000366
    • Spectrum5_001074
    • Triclormetiazide [Italian]
    • C03AA06
    • AB00052117_16
    • BRD-A28940325-001-05-9
    • KBio2_003568
    • Q-201860
    • SR-01000000284-2
    • Trichlormethiazidum
    • HY-B0235
    • Tox21_110421_1
    • Prestwick2_000825
    • NINDS_000366
    • NSC-757368
    • NSC61560
    • Trichlormethiazide (USP:INN:JAN)
    • Trichlormethiazidum [INN-Latin]
    • KBio3_002146
    • (3RS)-6-Chloro-3-dichloromethyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
    • CCG-212834
    • C72338
    • 6-Chloro-3-(dichloromethyl)-3,2,4-benzothiadiazine-7-sulfonamide1,1-dioxide
    • Triclormetiazida [INN-Spanish]
    • Trichlormethiazide (Achletin)
    • 6-chloro-3-(dichloromethyl)-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
    • 3-(Dichloromethyl)-6-chloro-7-sulfamoyl-3,2,4-benzothiadiazine 1,1-dioxide
    • TRICHLORMETHIAZIDE (USP MONOGRAPH)
    • 6-Chloro-3-dichloromethyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-dioxide
    • HMS1921G13
    • KBioSS_001000
    • TRICHLORMETHIAZIDE [VANDF]
    • E6,2,4-benzothiadiazine-7-sulfonamide
    • 6-chloro-3-(dichloromethyl)-1,1-dioxo-3,4-dihydro-2H-1
    • BRD-A28940325-001-24-0
    • BRD-A28940325-001-23-2
    • BRD-A28940325-001-25-7
    • MDL： MFCD00057315
    • Inchi： 1S/C8H8Cl3N3O4S2/c9-3-1-4-6(2-5(3)19(12,15)16)20(17,18)14-8(13-4)7(10)11/h1-2,7-8,13-14H,(H2,12,15,16)
    • InChI Key： LMJSLTNSBFUCMU-UHFFFAOYSA-N
    • SMILES： ClC(C1NC2C=C(C(=CC=2S(N1)(=O)=O)S(N)(=O)=O)Cl)Cl

Computed Properties

  • Exact Mass: 378.90200
  • Monoisotopic Mass: 378.902
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 3
  • Hydrogen Bond Acceptor Count: 7
  • Heavy Atom Count: 20
  • Rotatable Bond Count: 2
  • Complexity: 571
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 1
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: nothing
  • XLogP3: 0.6
  • Topological Polar Surface Area: 135

Experimental Properties

  • Density: 1.748
  • Melting Point: 248-250 oC
  • Boiling Point: 631.3°C at 760 mmHg
  • Flash Point: 335.6°C
  • Refractive Index: 1.6000 (estimate)
  • PSA: 135.12000
  • LogP: 4.14970
  • Merck: 9624

Trichlormethiazide Security Information

  • Symbol: GHS08
  • Signal Word：Danger
  • Hazard Statement： H317-H334
  • Warning Statement： P261-P280-P342+P311
  • Hazardous Material transportation number：NONH for all modes of transport
  • WGK Germany：2
  • Hazard Category Code： 42/43
  • Safety Instruction： S36
  • RTECS：DK8925000
  • Hazardous Material Identification： Xn
  • Safety Term：S36
  • Risk Phrases：R42/43
  • Toxicity：LD50 orally in rats: >20000 mg/kg (Goldenthal)
  • HazardClass：6.1
  • PackingGroup：Ⅲ
  • Storage Condition：4°C, protect from light

Trichlormethiazide Customs Data

  • HS CODE：2935009090
  • Customs Data：

    China Customs Code:

    2935009090

    Overview:

    2935009090 Other sulphonates(Acyl)amine. VAT:17.0% Tax refund rate:9.0% Regulatory conditions:nothing MFN tariff:6.5% general tariff:35.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Trichlormethiazide Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd.
T863687-5g
Trichlormethiazide
 133-67-5 ≥98%
5g
 ￥378.90 2022-08-31
WU HAN AN JIE KAI Biomedical Technology Co., Ltd.
ajci6668-50mg
Trichlormethiazide
 133-67-5 98%
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 ￥592.00 2023-09-09
SHANG HAI TAO SHU Biotechnology Co., Ltd.
T0114-500 mg
Trichlormethiazide
 133-67-5 99.54%
500MG
 ￥395.00 2022-04-26
SHANG HAI TAO SHU Biotechnology Co., Ltd.
T0114-1 g
Trichlormethiazide
 133-67-5 99.54%
1g
 ￥485.00 2022-04-26
SHANG HAI TAO SHU Biotechnology Co., Ltd.
T0114-1 mL * 10 mM (in DMSO)
Trichlormethiazide
 133-67-5 99.54%
1 mL * 10 mM (in DMSO)
 ￥485.00 2022-04-26
SHANG HAI YI EN HUA XUE JI SHU Co., Ltd.
R022219-25g
Trichlormethiazide
 133-67-5 98%
25g
 ￥1134 2024-05-26
SHANG HAI YI EN HUA XUE JI SHU Co., Ltd.
R022219-5g
Trichlormethiazide
 133-67-5 98%
5g
 ￥365 2024-05-26
S e l l e c k ZHONG GUO
S1667-50mg
Trichlormethiazide
 133-67-5 99.36%
50mg
 ￥814.51 2023-09-15
MedChemExpress
HY-B0235-10mM*1mLinDMSO
Trichlormethiazide
 133-67-5 98.59%
10mM*1mLinDMSO
 ￥500 2023-07-26
MedChemExpress
HY-B0235-500mg
Trichlormethiazide
 133-67-5 98.59%
500mg
 ￥400 2024-04-20

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