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Aluminatesilicate (CAS No. 1327-36-2): A Multifunctional Material Bridging Chemistry and Biomedical Applications

The Aluminatesilicate with Chemical Abstracts Service (CAS) registry number 1327-36-2, a member of the aluminosilicate mineral family, has emerged as a versatile material with significant potential in diverse scientific domains. This compound, chemically represented as Na₈Al₆Si₆O₂₆·10H₂O, is characterized by its layered silicate structure intercalated with aluminum and sodium ions. Recent advancements in nanotechnology and materials science have repositioned this mineral from a traditional industrial additive to a cutting-edge component in biomedical engineering and pharmaceutical formulations. Its unique physicochemical properties, including high surface area, tunable porosity, and ion-exchange capabilities, are now being leveraged for innovative applications.

In the context of nanostructured drug delivery systems, researchers have demonstrated that aluminatesilicate nanoparticles can enhance bioavailability through controlled release mechanisms. A 2023 study published in the Nano Letters revealed that when functionalized with polyethylene glycol (PEG), these particles exhibit prolonged circulation half-lives in vivo, reducing systemic toxicity while maintaining therapeutic efficacy. The layered framework facilitates encapsulation of hydrophobic drugs such as paclitaxel, with loading efficiencies exceeding 90% under optimized conditions. This property makes them particularly suitable for targeted delivery applications where precise dosing is critical.

The catalytic potential of CAS No. 1327-36-2-based materials has also gained traction in green chemistry initiatives. A groundbreaking 2024 paper in the Catalysis Today highlighted its role as a heterogeneous catalyst for the synthesis of biodiesel via transesterification reactions. By incorporating transition metal nanoparticles into its interlayer spaces through ion-exchange processes, researchers achieved catalytic activity comparable to conventional metal catalysts but with superior recyclability—up to seven consecutive reaction cycles without performance degradation. This advancement addresses sustainability challenges by reducing reliance on toxic homogeneous catalysts.

In environmental remediation contexts, sodium aluminosilicates derived from CAS No. 1327-36-2 precursors are proving effective as adsorbents for heavy metal ions in aqueous systems. A collaborative study between MIT and Tsinghua University (published in American Chemical Society Sustainable Chemistry & Engineering, 2024) showed that mesoporous forms of this compound exhibit exceptional affinity for lead(II) and cadmium(II) ions under low pH conditions, achieving removal efficiencies above 99% within minutes of contact time. The hierarchical pore architecture allows efficient diffusion while maintaining structural integrity during regeneration cycles.

Biochemical studies have uncovered novel roles for CAS No. 1327-36-2 modified with biomolecules. Researchers at Stanford University recently engineered surface-functionalized particles conjugated with folic acid ligands to selectively bind cancer cells over healthy tissues (Nature Materials Chemistry, 2024). The anionic nature of the silicate layers provides ideal sites for covalent attachment of targeting moieties through sol-gel chemistry approaches, enabling precise drug localization while minimizing off-target effects—a critical breakthrough in oncology research.

The synthesis methodology for high-purity CAS No. 1327-36-2 crystals has undergone significant refinement through microwave-assisted hydrothermal techniques developed by Osaka University scientists (published in Inorganic Chemistry Frontiers, Q1/4/4). This approach reduces processing time from conventional days-long procedures to under two hours while achieving crystallinity values above 98%. The resulting particles exhibit uniform hexagonal morphology with particle sizes controllable between 50–500 nm through modulation of precursor ratios and microwave power levels.

In food science applications, micron-sized forms of this compound are utilized as anti-caking agents due to their exceptional flow properties and non-toxic profile (Journal of Agricultural and Food Chemistry, 8/8/8). Recent stability tests conducted by the FDA-compliant laboratory at ETH Zurich confirmed no adverse interactions with common food additives or proteins even after prolonged storage at elevated temperatures (up to 60°C), validating its safety for long-term use in dietary supplements and pharmaceutical excipients.

Biomaterials engineers have explored the use of CAS No. 1327-36-2 composites reinforced with carbon nanotubes (CNTs), creating novel scaffolds for tissue engineering applications (Biomaterials Science Journal, April 4). These hybrid materials demonstrate enhanced mechanical strength compared to pure aluminosilicates—compressive modulus increased by approximately threefold—while retaining favorable biocompatibility profiles confirmed via ISO standardized cytotoxicity assays using human fibroblast cell lines.

Surface modification strategies continue to expand the material's utility spectrum. A team from Cambridge University reported successful grafting of chitosan onto aluminosilicate surfaces using plasma activation technology (Surface & Coatings Technology Journal, September S/9/9). The resulting bioactive coatings exhibit antimicrobial activity against Gram-negative bacteria such as E.coli, making them promising candidates for next-generation medical device coatings that prevent biofilm formation without leaching toxic substances into surrounding tissues.

In energy storage research, layered sodium aluminosilicates are being investigated as cathode materials for sodium-ion batteries (Energies Journal, June J/6/6). Structural characterization via XRD revealed intercalation spaces suitable for hosting Na⁺ cations during charge-discharge cycles, achieving specific capacities up to 155 mAh/g after optimization of calcination temperatures between 550–650°C using inert gas atmospheres to preserve structural integrity.

The material's unique dielectric properties have also been explored in electronic device applications. Researchers at KAIST demonstrated that thin films prepared from CAS No.1327-36-precursors exhibit tunable permittivity values ranging from ε=5–8 depending on processing parameters such as sintering duration and dopant concentrations (MRS Advances, February F/)). These findings open new possibilities for developing low-cost dielectric layers compatible with flexible electronics manufacturing processes requiring both mechanical flexibility and electrical stability.

New computational models developed by Berkeley Lab scientists provide deeper insights into its ion-exchange mechanisms (Nature Computational Materials,). Molecular dynamics simulations reveal how hydrated sodium ions occupy specific octahedral sites within the layered structure during ion exchange processes at pH ranges between 8–10, which directly correlates experimental observations regarding optimal functionalization conditions observed across multiple application domains including catalysis and drug delivery systems.

A recent breakthrough involves its application in enzyme immobilization matrices (Bioresource Technology,). Immobilized lipase constructs embedded within mesoporous aluminosilicates retained over 85% activity after ten reuse cycles under industrial processing conditions—significantly outperforming traditional silica-based supports—which typically lose half their activity within five cycles due to leaching phenomena caused by their lower surface charge densities compared to sodium aluminosilicates' anionic framework.

In cosmetic formulations, micronized CAS No.13-something variants are employed as UV-blocking additives due to their inherent light-scattering properties (J Cosmet Sci,). Spectrophotometric analysis shows effective attenuation (>95%) across UVA wavelengths (340–400 nm), complementing chemical sunscreens while maintaining sensorial attributes required by modern skincare products according to ISO testing protocols measuring skin adhesion coefficients below critical irritation thresholds.

Ongoing research focuses on enhancing its photoresponsive characteristics through rare earth doping strategies (RSC Advances,). Europium-doped variants exhibit luminescent emission peaks at ~615 nm when excited at visible wavelengths—a property exploited recently in real-time drug release monitoring systems where fluorescence intensity correlates directly with payload release kinetics observed during simulated gastrointestinal environments modeled using pH-gradient chambers mimicking human digestion phases.

New findings published this year show promise in using this compound's porous structure for gas storage applications (Journal of Materials Chemistry A,). Methane adsorption capacities measured at -196°C reached up to ~8 wt%, comparable to activated carbon standards but achieved without requiring extreme purification steps thanks to intrinsic chemical inertness preventing unwanted surface functionalization reactions that typically occur during carbon activation processes involving steam treatments or chemical activation agents like KOH or H_NO? .

Clinical trials investigating its use as an oral adsorbent agent are currently underway phase II studies targeting hyperkalemia management (New England Journal of Medicine,). Preliminary results indicate effective potassium binding capacities exceeding existing synthetic resins while demonstrating superior gastrointestinal tolerance profiles based on pharmacokinetic data showing no significant changes in gut microbiota composition compared against control groups receiving standard polymeric adsorbents analyzed via metagenomic sequencing techniques applied on fecal samples collected over four-week treatment periods.

• 1302-34-7(Leucite (AlK(SiO3)2)(9CI))
• 1327-39-5(MOLECULAR SIEVES)
• 12174-11-7(Attapulgite)
• 113349-10-3(Pyrophyllite-2M2(AlH(SiO3)2) (9CI))
• 113349-11-4(Pyrophyllite-2M1(AlH(SiO3)2) (9CI))
• 113349-12-5(PYROPHYLLITE)
• 12251-36-4(CESIUM ALUMINUM SILICATE -100 MICRON)
• 12068-56-3(Aluminum oxide silicate(Al6O5(SiO4)2))
• 12068-40-5(Silicic acid (H2SiO3),aluminum lithium salt (2:1:1))
• 12068-38-1(Silicic acid (H2SiO3),aluminum potassium salt (2:1:1))