• 1. Emerging investigator series: bacteriophages as nano engineering tools for quality monitoring and pathogen detection in water and wastewater
  Fereshteh Bayat Environ. Sci.: Nano, 2021,8, 367-389
• 2. Dissociative dynamics of O2 on Ag(110)?
  Ivor Lon?ari? Phys. Chem. Chem. Phys., 2015,17, 9436-9445
• 3. Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers?
  Zhixia Liu,Tingjian Chen,Floyd E. Romesberg Chem. Sci., 2017,8, 8179-8182
• 4. Excess electrons in lithium–ethylamine solutions—density, electrical conductivity and EPR studies
  Phys. Chem. Chem. Phys., 1999,1, 3561-3565
• 5. Establishment and implications of a characterization method for magnetic nanoparticle using cell tracking velocimetry and magnetic susceptibility modified solutions
  Huading Zhang,Lee R. Moore,Maciej Zborowski,P. Stephen Williams,Shlomo Margel,Jeffrey J. Chalmers Analyst, 2005,130, 514-527

• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenols 1-hydroxy-2-unsubstituted benzenoids

Recent Advances in the Study of (R)-2-Hydroxy-2-(4-hydroxyphenyl)acetic acid (CAS: 13244-78-5)

The compound (R)-2-Hydroxy-2-(4-hydroxyphenyl)acetic acid (CAS: 13244-78-5) has garnered significant attention in the field of chemical biology and pharmaceutical research due to its potential therapeutic applications. This chiral molecule, characterized by its hydroxyl and carboxyl functional groups, has been the subject of recent studies focusing on its synthesis, biological activity, and pharmacological properties. The latest research highlights its role as a key intermediate in the production of bioactive compounds and its potential as a therapeutic agent in various diseases.

Recent studies have explored the efficient synthesis of (R)-2-Hydroxy-2-(4-hydroxyphenyl)acetic acid using biocatalytic methods, which offer advantages such as high enantioselectivity and environmental sustainability. Researchers have employed enzymes like hydroxynitrile lyases and engineered ketoreductases to achieve high yields and purity of the (R)-enantiomer. These advancements are critical for scaling up production and ensuring the compound's availability for further pharmacological studies.

In terms of biological activity, (R)-2-Hydroxy-2-(4-hydroxyphenyl)acetic acid has demonstrated promising anti-inflammatory and antioxidant properties. In vitro studies have shown that the compound can inhibit the production of pro-inflammatory cytokines and reactive oxygen species, suggesting its potential in treating inflammatory diseases such as rheumatoid arthritis and neurodegenerative disorders. Additionally, its chiral nature has been found to play a crucial role in its interaction with biological targets, underscoring the importance of enantiopure synthesis.

Pharmacological evaluations have further revealed that (R)-2-Hydroxy-2-(4-hydroxyphenyl)acetic acid exhibits favorable pharmacokinetic properties, including good oral bioavailability and metabolic stability. Animal studies have indicated its ability to cross the blood-brain barrier, making it a candidate for central nervous system-targeted therapies. These findings are supported by molecular docking studies, which highlight the compound's affinity for key enzymes and receptors involved in disease pathways.

The potential applications of (R)-2-Hydroxy-2-(4-hydroxyphenyl)acetic acid extend beyond its direct therapeutic use. Recent research has explored its incorporation into prodrugs and drug delivery systems, leveraging its functional groups for conjugation with other bioactive molecules. Such strategies aim to enhance drug solubility, stability, and targeted delivery, thereby improving therapeutic outcomes.

In conclusion, the latest research on (R)-2-Hydroxy-2-(4-hydroxyphenyl)acetic acid (CAS: 13244-78-5) underscores its versatility and potential in chemical biology and pharmaceutical development. Advances in synthesis, coupled with a deeper understanding of its biological and pharmacological properties, pave the way for its future application in drug discovery and therapy. Continued research is expected to further elucidate its mechanisms of action and expand its therapeutic scope.

• 7198-10-9(DL-4-Hydroxymandelic acid)
• 75172-66-6((2S)-2-hydroxy-2-(4-methoxyphenyl)acetic acid)
• 10502-44-0(4-Methoxymandelic acid)
• 184901-84-6(4-Hydroxymandelic Acid Monohydrate)
• 20714-89-0((R)-2-Hydroxy-2-(4-methoxyphenyl)acetic acid)
• 1198-84-1(4-Hydroxymandelic Acid)
• 14883-87-5((2R)-2-(3,4-dihydroxyphenyl)-2-hydroxy-acetate)
• 775-01-9(rac 3,4-Dihydroxymandelic Acid)
• 17119-15-2(3-Hydroxymandelic acid)
• 189506-56-7(Benzeneacetic acid, a,3,4,5-tetrahydroxy-)